scholarly journals Distinguishing Endogenousd-Amino Acid-Containing Neuropeptides in Individual Neurons Using Tandem Mass Spectrometry

2011 ◽  
Vol 83 (7) ◽  
pp. 2794-2800 ◽  
Author(s):  
Lu Bai ◽  
Elena V. Romanova ◽  
Jonathan V. Sweedler
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Tandem Mass Spectrometry ◽  
Tandem Mass

scholarly journals Determination of free amino acids in plants by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)

2015 ◽  
Vol 7 (18) ◽  
pp. 7574-7581 ◽  
Author(s):  
Magdalena M. Dziągwa-Becker ◽  
Jose M. Marin Ramos ◽  
Jakub K. Topolski ◽  
Wiesław A. Oleszek
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
Liquid Chromatography ◽  
Amino Acid ◽  
Tandem Mass Spectrometry ◽  
Free Amino ◽  
Tandem Mass ◽  
Amino Acid Determination ◽  
Acid Determination

Free amino acid determination in plants by LC-MS/MS.

Parvalbumin isoforms in chicken muscle and thymus. Amino acid sequence analysis of muscle parvalbumin by tandem mass spectrometry

Biochemistry ◽  
1991 ◽  
Vol 30 (36) ◽  
pp. 8812-8816 ◽  
Author(s):  
Thomas Kuster ◽  
Werner Staudenmann ◽  
Graham J. Hughes ◽  
Claus W. Heizmann
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Sequence Analysis ◽  
Amino Acid Sequence ◽  
Tandem Mass Spectrometry ◽  
Tandem Mass ◽  
Amino Acid Sequence Analysis ◽  
Chicken Muscle

scholarly journals Electrospray Tandem Mass Spectrometry for Analysis of Acylcarnitines in Dried Postmortem Blood Specimens Collected at Autopsy from Infants with Unexplained Cause of Death

2001 ◽  
Vol 47 (7) ◽  
pp. 1166-1182 ◽  
Author(s):  
Donald H Chace ◽  
James C DiPerna ◽  
Brenda L Mitchell ◽  
Bethany Sgroi ◽  
Lindsay F Hofman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acid ◽  
Amino Acid ◽  
Tandem Mass Spectrometry ◽  
Metabolic Disorders ◽  
Tandem Mass ◽  
Postmortem Blood ◽  
Blood Specimens ◽  
Medical Examiners ◽  
Long Chain

Abstract Background: Deaths from inherited metabolic disorders may remain undiagnosed after postmortem examination and may be classified as sudden infant death syndrome. Tandem mass spectrometry (MS/MS) may reveal disorders of fatty acid oxidation in deaths of previously unknown cause. Methods: We obtained filter-paper blood from 7058 infants from United States and Canadian Medical Examiners. Acylcarnitine and amino acid profiles were obtained by MS/MS. Specialized interpretation was used to evaluate profiles for disorders of fatty acid, organic acid, and amino acid metabolism. The analyses of postmortem blood specimens were compared with the analyses of bile specimens, newborn blood specimens, and specimens obtained from older infants at risk for metabolic disorders. Results: Results on 66 specimens suggested diagnoses of metabolic disorders. The most frequently detected disorders were medium-chain and very-long-chain acyl-CoA dehydrogenase deficiencies (23 and 9 cases, respectively), glutaric acidemia type I and II deficiencies (3 and 8 cases, respectively), carnitine palmitoyl transferase type II/translocase deficiencies (6 cases), severe carnitine deficiency (4 cases), isovaleric acidemia/2-methylbutyryl-CoA dehydrogenase deficiencies (4 cases), and long-chain hydroxyacyl-CoA dehydrogenase/trifunctional protein deficiencies (4 cases). Conclusions: Postmortem metabolic screening can explain deaths in infants and children and provide estimates of the number of infant deaths attributable to inborn errors of metabolism. MS/MS is cost-effective for analysis of postmortem specimens and should be considered for routine use by Medical Examiners and pathologists in unexpected/unknown infant and child death.

Isobutyryl-CoA dehydrogenase deficiency with a novel ACAD8 gene mutation detected by tandem mass spectrometry newborn screening

2007 ◽  
Vol 45 (11) ◽  
Author(s):  
Eun-Hyung Yoo ◽  
Hyun-Jung Cho ◽  
Chang-Seok Ki ◽  
Soo-Youn Lee
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Tandem Mass Spectrometry ◽  
Metabolic Disorder ◽  
Dehydrogenase Deficiency ◽  
Elevated Concentration ◽  
Tandem Mass ◽  
Branched Chain Amino Acid ◽  
Branched Chain ◽  
Rare Metabolic Disorder

AbstractIsobutyryl-CoA dehydrogenase (IBD) is an enzyme involved in the catabolism of the branched-chain amino acid valine. IBD deficiency is a very rare metabolic disorder, whereby only a few cases have been reported thus far. Recently, we observed a Korean newborn boy with elevated concentration of CClin Chem Lab Med 2007;45:1495–7.

Characterization of amino acid-derived betaines by electrospray ionization tandem mass spectrometry

2012 ◽  
Vol 47 (1) ◽  
pp. 79-88 ◽  
Author(s):  
V. Naresh Chary ◽  
Ch. Dinesh Kumar ◽  
M. Vairamani ◽  
S. Prabhakar
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Tandem Mass Spectrometry ◽  
Electrospray Ionization ◽  
Tandem Mass ◽  
Ionization Tandem Mass Spectrometry

Amino Acid Sequence Analysis of Human S100A7 (Psoriasin) by Tandem Mass Spectrometry

1995 ◽  
Vol 217 (1) ◽  
pp. 257-263 ◽  
Author(s):  
D.M. Burgisser ◽  
G. Siegenthaler ◽  
T. Kuster ◽  
U. Hellman ◽  
P. Hunziker ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Sequence Analysis ◽  
Amino Acid Sequence ◽  
Tandem Mass Spectrometry ◽  
Tandem Mass ◽  
Amino Acid Sequence Analysis
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