scholarly journals Mass Spectrometry-Based Analysis of Rat Liver and Hepatocellular Carcinoma Morris Hepatoma 7777 Plasma Membrane Proteome

2013 ◽  
Vol 85 (17) ◽  
pp. 8112-8120 ◽  
Author(s):  
Lulu Cao ◽  
James G. Clifton ◽  
Werner Reutter ◽  
Djuro Josic
Keyword(s):  
Mass Spectrometry ◽  
Hepatocellular Carcinoma ◽  
Plasma Membrane ◽  
Rat Liver ◽  
Membrane Proteome ◽  
Morris Hepatoma

scholarly journals Different turnover of fucose residues in plasma membranes of rat liver and Morris hepatoma 7777

1980 ◽  
Vol 190 (1) ◽  
pp. 51-55 ◽  
Author(s):  
P Vischer ◽  
W Reutter
Keyword(s):  
Plasma Membrane ◽  
Sialic Acid ◽  
Rat Liver ◽  
Rate Constants ◽  
Plasma Membranes ◽  
Total Cell ◽  
Host Liver ◽  
Morris Hepatoma

Half-lives and rate constants of degradation of protein-bound fucose have been determined in plasma membranes and total cell homogenates of rat liver and Morris hepatoma 7777. The existence of at least two dynamically different classes of fucose-containing glycoproteins could be demonstrated in both liver and hepatoma plasma membranes. The apparent half-lives were 8.4 and 24.5 h (host liver) and 11.5 and 33.9 h (Morris hepatoma). Since this biphasic loss of fucose residues was not observed for sialic acid [Harms & Reutter (1974) Cancer Res. 34, 3165–3172], the differences are possibly related to specific functions of fucosylated glycoproteins of the plasma membrane.

scholarly journals Glucagon-(19-29), a Ca2+ pump inhibitory peptide, is processed from glucagon in the rat liver plasma membrane by a thiol endopeptidase.

1990 ◽  
Vol 265 (35) ◽  
pp. 21514-21519 ◽  
Author(s):  
P Blache ◽  
A Kervran ◽  
M Dufour ◽  
J Martinez ◽  
D Le-Nguyen ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Rat Liver ◽  
Inhibitory Peptide ◽  
Liver Plasma Membrane

scholarly journals Molecular architecture of the endocytic TPLATE complex

2021 ◽  
Vol 7 (9) ◽  
pp. eabe7999
Author(s):  
Klaas Yperman ◽  
Jie Wang ◽  
Dominique Eeckhout ◽  
Joanna Winkler ◽  
Lam Dai Vu ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Structural Approach ◽  
Eukaryotic Cells ◽  
Molecular Architecture ◽  
Membrane Proteome ◽  
Complex Assembly ◽  
Membrane Interaction ◽  
Structural Insight ◽  
Fresh Insight ◽  
Insight Into

Eukaryotic cells rely on endocytosis to regulate their plasma membrane proteome and lipidome. Most eukaryotic groups, except fungi and animals, have retained the evolutionary ancient TSET complex as an endocytic regulator. Unlike other coatomer complexes, structural insight into TSET is lacking. Here, we reveal the molecular architecture of plant TSET [TPLATE complex (TPC)] using an integrative structural approach. We identify crucial roles for specific TSET subunits in complex assembly and membrane interaction. Our data therefore generate fresh insight into the differences between the hexameric TSET in Dictyostelium and the octameric TPC in plants. Structural elucidation of this ancient adaptor complex represents the missing piece in the coatomer puzzle and vastly advances our functional as well as evolutionary insight into the process of endocytosis.

In vitrometabolism of specific CYP2D and CYP3A opioid substrates using rat liver S9 fractions and mass spectrometry reveal a severe metabolic impairment with increasing age

2016 ◽  
Vol 31 (2) ◽  
pp. e3786 ◽  
Author(s):  
Sabrin Fuad Salmin ◽  
Marie-Chantal Giroux ◽  
Pascal Vachon ◽  
Francis Beaudry
Keyword(s):  
Mass Spectrometry ◽  
Rat Liver
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