Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry

Exchange Chromatography ◽

Charge Heterogeneity ◽

Strong Cation Exchange ◽

Therapeutic Monoclonal Antibodies

Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies

mAbs ◽

10.1080/19420862.2020.1763762 ◽

2020 ◽

Vol 12 (1) ◽

pp. 1763762

Author(s):

Fengfei Ma ◽

Fahimeh Raoufi ◽

Marc Andre Bailly ◽

Laurence Fayadat-Dilman ◽

Daniela Tomazela

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Exchange Chromatography ◽

Charge Heterogeneity ◽

Strong Cation Exchange ◽

Therapeutic Monoclonal Antibodies

Determination of Cerebrospinal Fluid Proteome Variations by Isobaric Labeling Coupled with Strong Cation-Exchange Chromatography and Tandem Mass Spectrometry

Methods in Molecular Biology - Cerebrospinal Fluid (CSF) Proteomics ◽

10.1007/978-1-4939-9706-0_10 ◽

2019 ◽

pp. 155-168 ◽

Cited By ~ 2

Author(s):

Mercedes Lachén-Montes ◽

Andrea González-Morales ◽

Joaquín Fernández-Irigoyen ◽

Enrique Santamaría

Keyword(s):

Mass Spectrometry ◽

Cerebrospinal Fluid ◽

Tandem Mass Spectrometry ◽

Cation Exchange ◽

Exchange Chromatography ◽

Tandem Mass ◽

Strong Cation Exchange ◽

Speciation of cationic selenium compounds in Brassica juncea leaves by strong cation-exchange chromatography with inductively coupled plasma mass spectrometry

Journal of Chromatography A ◽

10.1016/j.chroma.2005.09.025 ◽

2005 ◽

Vol 1100 (2) ◽

pp. 153-159 ◽

Cited By ~ 23

Author(s):

Santha V. Ketavarapu Yathavakilla ◽

Monika Shah ◽

Sandra Mounicou ◽

Joseph A. Caruso

Keyword(s):

Mass Spectrometry ◽

Cation Exchange ◽

Inductively Coupled Plasma ◽

Exchange Chromatography ◽

Selenium Compounds ◽

Inductively Coupled ◽

Strong Cation Exchange ◽

Plasma Mass Spectrometry ◽

Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.7b05241 ◽

2018 ◽

Vol 90 (7) ◽

pp. 4669-4676 ◽

Cited By ~ 43

Author(s):

Florian Füssl ◽

Ken Cook ◽

Kai Scheffler ◽

Amy Farrell ◽

Stefan Mittermayr ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

High Resolution ◽

Cation Exchange ◽

Exchange Chromatography ◽

Ph Gradient ◽

Variant Analysis

Redox speciation of iron, manganese, and copper in cerebrospinal fluid by strong cation exchange chromatography – sector field inductively coupled plasma mass spectrometry

Analytica Chimica Acta ◽

10.1016/j.aca.2017.03.040 ◽

2017 ◽

Vol 973 ◽

pp. 25-33 ◽

Cited By ~ 26

Author(s):

Nikolay Solovyev ◽

Marco Vinceti ◽

Peter Grill ◽

Jessica Mandrioli ◽

Bernhard Michalke

Keyword(s):

Mass Spectrometry ◽

Cerebrospinal Fluid ◽

Inductively Coupled Plasma ◽

Exchange Chromatography ◽

Inductively Coupled ◽

Strong Cation Exchange ◽

Plasma Mass Spectrometry ◽

Iron Manganese

Simultaneous monitoring of monoclonal antibody variants by strong cation-exchange chromatography hyphenated to mass spectrometry to assess biosimilar-ity of rituximab-based biotherapeutics

10.33774/chemrxiv-2021-87m9w ◽

2021 ◽

Author(s):

Christian G. Huber ◽

Fiammetta Di Marco ◽

Thomas Berger ◽

Wolfgang Esser-Skala ◽

Erdmann Rapp ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Cation Exchange ◽

Exchange Chromatography ◽

Strong Cation Exchange ◽

Towards a simple on-line coupling of ion exchange chromatography and native mass spectrometry for the detailed characterization of monoclonal antibodies

Journal of Chromatography A ◽

10.1016/j.chroma.2021.462499 ◽

2021 ◽

Vol 1655 ◽

pp. 462499

Author(s):

Amarande Murisier ◽

Bastiaan L. Duivelshof ◽

Szabolcs Fekete ◽

Julien Bourquin ◽

Andrew Schmudlach ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Ion Exchange ◽

Ion Exchange Chromatography ◽

Exchange Chromatography ◽

Detailed Characterization ◽

On Line ◽

Line Coupling

Strong cation-exchange chromatography of proteins on a sulfoalkylated monolithic cryogel

Journal of Chromatography A ◽

10.1016/j.chroma.2015.01.075 ◽

2015 ◽

Vol 1386 ◽

pp. 13-21 ◽

Cited By ~ 18

Author(s):

Işık Perçin ◽

Rushd Khalaf ◽

Bastian Brand ◽

Massimo Morbidelli ◽

Orhan Gezici

Keyword(s):

Cation Exchange ◽

Exchange Chromatography ◽

Strong Cation Exchange ◽

Utilizing mAb Adsorption Isotherms To Direct Process Development of a Strong Cation-Exchange Chromatography Step

ACS Symposium Series - Developments in Biotechnology and Bioprocessing ◽

10.1021/bk-2013-1125.ch004 ◽

2013 ◽

pp. 51-65 ◽

Cited By ~ 1

Author(s):

Christopher Gillespie

Keyword(s):

Cation Exchange ◽

Adsorption Isotherms ◽

Process Development ◽

Exchange Chromatography ◽

Direct Process ◽

Strong Cation Exchange ◽

Chromatography Step

Online coupling of analytical hydrophobic interaction chromatography with native mass spectrometry for the characterization of monoclonal antibodies and related products

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2020.113313 ◽

2020 ◽

Vol 186 ◽

pp. 113313 ◽

Cited By ~ 2

Author(s):

Yuetian Yan ◽

Tao Xing ◽

Shunhai Wang ◽

Thomas J. Daly ◽

Ning Li

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibodies ◽

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography ◽

Native Mass Spectrometry