In Vitro Evaluation of Doxorubicin Conjugates Based on Sugar Core Nonlinear Polymethacrylates toward Anticancer Drug Delivery

2016 ◽  
Vol 27 (4) ◽  
pp. 893-904 ◽  
Author(s):  
A. Mielańczyk ◽  
M. Skonieczna ◽  
Ł. Mielańczyk ◽  
D. Neugebauer
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
In Vitro Evaluation ◽  
Anticancer Drug Delivery

Synthesis and in vitro evaluation of pH-sensitive PEG-I-dC16 block polymer micelles for anticancer drug delivery

2016 ◽  
Vol 68 (6) ◽  
pp. 751-761 ◽  
Author(s):  
Huang Rongbin ◽  
Xiang Lei ◽  
Liu Ying ◽  
Deng Xiangping ◽  
Cao Xuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Ph Sensitive ◽  
Polymer Micelles ◽  
In Vitro Evaluation ◽  
Block Polymer ◽  
Anticancer Drug Delivery

Facile construction of stabilized, pH-sensitive micelles based on cyclic statistical copolymers of poly(oligo(ethylene glycol)methyl ether methacrylate-st-N,N-dimethylaminoethyl methacrylate) for in vitro anticancer drug delivery

2020 ◽  
Vol 11 (38) ◽  
pp. 6139-6148
Author(s):  
Miao Zhang ◽  
Ying Liu ◽  
Jinlei Peng ◽  
Yuping Liu ◽  
Fangjun Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Anticancer Drug ◽  
Methyl Ether ◽  
Colloidal Stability ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery ◽  
Dimethylaminoethyl Methacrylate ◽  
Glycol Methyl Ether

This study developed a facile approach to improve the colloidal stability of a cyclic polycation as well as presented a pH-sensitive cyclic copolymer-based nanoplatform with great potential for anticancer drug delivery.

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

Chitosan nanoparticles for lipophilic anticancer drug delivery: Development, characterization and in vitro studies on HT29 cancer cells

2016 ◽  
Vol 145 ◽  
pp. 362-372 ◽  
Author(s):  
Angela Abruzzo ◽  
Giampaolo Zuccheri ◽  
Federica Belluti ◽  
Simona Provenzano ◽  
Laura Verardi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Chitosan Nanoparticles ◽  
In Vitro Studies ◽  
Anticancer Drug Delivery
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