Design and Synthesis of Potent, Long-Acting Lipidated Relaxin-2 Analogs

2018 ◽  
Vol 30 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Avinash Muppidi ◽  
Sang Jun Lee ◽  
Che-Hsiung Hsu ◽  
Huafei Zou ◽  
Candy Lee ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Relaxin 2 ◽  
Long Acting

scholarly journals Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration

2017 ◽  
Vol 60 (12) ◽  
pp. 5057-5071 ◽  
Author(s):  
Matthew W. D. Perry ◽  
Karin Björhall ◽  
Britta Bonn ◽  
Johan Carlsson ◽  
Yunhua Chen ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Long Acting

The Design and Synthesis of Long-Acting Oxytocin Antagonists Substituted in Positions 2, 7, and 8

Peptides ◽  
1994 ◽  
pp. 199-208 ◽  
Author(s):  
Victor J. Hruby ◽  
W. Y. Chan ◽  
Todd W. Rockway ◽  
Jan Hlavacek ◽  
James Ormberg
Keyword(s):  
Design And Synthesis ◽  
Oxytocin Antagonists ◽  
Long Acting

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application

2013 ◽  
Vol 23 (1) ◽  
pp. 310-317 ◽  
Author(s):  
Bart Kesteleyn ◽  
Katie Amssoms ◽  
Wim Schepens ◽  
Geerwin Hache ◽  
Wim Verschueren ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Drug Application ◽  
Injectable Drug ◽  
Design And Synthesis ◽  
Long Acting ◽  
Hiv 1

Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

1997 ◽  
Vol 40 (12) ◽  
pp. 1779-1788 ◽  
Author(s):  
Benny C. Askew ◽  
Rodney A. Bednar ◽  
Bohumil Bednar ◽  
David A. Claremon ◽  
Jacquelynn J. Cook ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Design And Synthesis ◽  
Fibrinogen Receptor ◽  
Long Acting ◽  
Orally Active

Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV

2007 ◽  
Vol 15 (7) ◽  
pp. 2715-2735 ◽  
Author(s):  
Takashi Kondo ◽  
Isamu Sugimoto ◽  
Takahiro Nekado ◽  
Kenya Ochi ◽  
Tazumi Ohtani ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Design And Synthesis ◽  
Long Acting

Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases

2021 ◽  
Vol 64 (4) ◽  
pp. 2139-2150
Author(s):  
Sergio Mallart ◽  
Raffaele Ingenito ◽  
Elisabetta Bianchi ◽  
Alberto Bresciani ◽  
Simone Esposito ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Peptide Mimetics ◽  
Single Chain ◽  
Relaxin 2 ◽  
Long Acting

Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma

2011 ◽  
Vol 21 (19) ◽  
pp. 5826-5830 ◽  
Author(s):  
David S. Millan ◽  
Stephen A. Ballard ◽  
Sara Chunn ◽  
Joseph A. Dybowski ◽  
Craig K. Fulton ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Design And Synthesis ◽  
Long Acting

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

Sign in / Sign up

Export Citation Format

Share Document