Poly(ethylene oxide monomethyl ether)-block-poly(propylene succinate) Nanoparticles: Synthesis and Characterization, Enzymatic and Cellular Degradation, Micellar Solubilization of Paclitaxel, and in Vitro and in Vivo Evaluation

Core crosslinked nanoparticles were prepared via nanoemulsion stabilized by a poly(ethylene glycol)-bearing surfactant, which show high structural stability in vivo.

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The Synthesis and Characterization of a Novel Block Copolymer Consisting of Poly(Propylene Fumarate) and Poly(Ethylene Oxide)

MRS Proceedings ◽

10.1557/proc-394-167 ◽

1995 ◽

Vol 394 ◽

Author(s):

Laura J. Suggs ◽

Richard G. Payne ◽

Edmund Y. Kao ◽

Lawrence B. Alemany ◽

Michael J. Yaszemski ◽

...

Keyword(s):

Block Copolymer ◽

Ethylene Oxide ◽

Physical Properties ◽

Synthesis And Characterization ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Poly Propylene

A block copolymer was developed consisting of poly(propylene fumarate) (PPF) and poly(ethylene oxide) (PEO) blocks. The former component allows the copolymer to be crosslinked, while the latter component allows the physical properties to be controlled. The compositions and segmental lengths of the two components were varied, and the copolymer was subsequently characterized.

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Poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-g-poly(vinyl pyrrolidone): Synthesis and characterization

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2004.11.028 ◽

2005 ◽

Vol 285 (1) ◽

pp. 80-85 ◽

Cited By ~ 10

Author(s):

Yan Zhang ◽

Yeng Ming Lam

Keyword(s):

Ethylene Oxide ◽

Propylene Oxide ◽

Vinyl Pyrrolidone ◽

Synthesis And Characterization ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Poly Vinyl Pyrrolidone ◽

Poly Propylene

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Amphotericin B Encapsulated in Micelles Based on Poly(ethylene oxide)-block-poly(l-amino acid) Derivatives Exerts Reduced in Vitro Hemolysis but Maintains Potent in Vivo Antifungal Activity

Biomacromolecules ◽

10.1021/bm0257614 ◽

2003 ◽

Vol 4 (3) ◽

pp. 750-757 ◽

Cited By ~ 71

Author(s):

Monica L. Adams ◽

David R. Andes ◽

Glen S. Kwon

Keyword(s):

Amino Acid ◽

Antifungal Activity ◽

Ethylene Oxide ◽

Amphotericin B ◽

Amino Acid Derivatives ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

In Vivo Antifungal Activity

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Influence of Poly(Ethylene Glycol) End Groups on Poly(Ethylene Glycol)-Albumin System Properties as a Potential Degradable Tissue Scaffold

Journal of Functional Biomaterials ◽

10.3390/jfb10010001 ◽

2018 ◽

Vol 10 (1) ◽

pp. 1 ◽

Cited By ~ 3

Author(s):

Robyn Overby ◽

Dale Feldman

Keyword(s):

Ethylene Glycol ◽

Crosslinking Agent ◽

Poly Ethylene Glycol ◽

In Vivo Evaluation ◽

Tissue Scaffold ◽

Handling Characteristics ◽

Poly Ethylene ◽

The Stability

Chronic dermal lesions, such as pressure ulcers, are difficult to heal. Degradable tissue scaffold systems can be employed to serve as a provisional matrix for cellular ingrowth and facilitate regenerative healing during degradation. Degradable regenerative tissue scaffold matrices can be created by crosslinking albumin with functionalized poly(ethylene glycol) (PEG) polymers. The purpose of this study was to evaluate the stability of PEG-albumin scaffold systems formed using PEG polymers with three different functionalized end chemistries by quantifying in vitro system swellability to determine the most promising PEG crosslinking polymer for wound healing applications. Of the three polymers evaluated, PEG-succinimidyl glutarate (SG) exhibited consistent gelation and handling characteristics when used as the crosslinking agent with albumin. PEG-SG polymers were identified as an appropriate synthetic crosslinking moiety in a PEG-albumin scaffold system, and further in vitro and in vivo evaluation of this scaffold system is merited.

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