Amphotericin B Encapsulated in Micelles Based on Poly(ethylene oxide)-block-poly(l-amino acid) Derivatives Exerts Reduced in Vitro Hemolysis but Maintains Potent in Vivo Antifungal Activity

2003 ◽  
Vol 4 (3) ◽  
pp. 750-757 ◽  
Author(s):  
Monica L. Adams ◽  
David R. Andes ◽  
Glen S. Kwon
Keyword(s):  
Amino Acid ◽  
Antifungal Activity ◽  
Ethylene Oxide ◽  
Amphotericin B ◽  
Amino Acid Derivatives ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
In Vivo Antifungal Activity

scholarly journals In Vitro and In Vivo Antifungal Activity of AmBisome Compared to Conventional Amphotericin B and Fluconazole against Candida auris

2021 ◽  
Author(s):  
Janet Herrada ◽  
Ahmed Gamal ◽  
Lisa Long ◽  
Sonia P. Sanchez ◽  
Thomas S. McCormick ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Kidney Tissue ◽  
Treated Group ◽  
Untreated Group ◽  
Candida Auris ◽  
Fungal Burden ◽  
In Vivo Antifungal Activity

Antifungal activity of AmBisome against Candida auris was determined in vitro and in vivo. AmBisome showed MIC50 and MIC90 values of 1 and 2 μg/mL, respectively. Unlike conventional amphotericin B, significant in vivo efficacy was observed in the AmBisome 7.5 mg/kg -treated group in survival and reduction of kidney tissue fungal burden compared to the untreated group. Our data shows that AmBisome shows significant antifungal activity against C. auris in vitro as well as in vivo.

Mixed micellar nanoparticle of amphotericin b and poly styrene-block-poly ethylene oxide reduces nephrotoxicity but retains antifungal activity

2007 ◽  
Vol 30 (10) ◽  
pp. 1344-1349 ◽  
Author(s):  
Kun Han M. A. ◽  
Jalil Miah ◽  
Srinivasan Shanmugam ◽  
Chul Soon Yong ◽  
Han-Gon Choi ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Ethylene Oxide ◽  
Amphotericin B ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Relevance of polymer molecular weight to the in vitro/in vivo performances of ocular inserts based on poly(ethylene oxide)

2001 ◽  
Vol 220 (1-2) ◽  
pp. 169-177 ◽  
Author(s):  
G Di Colo ◽  
S Burgalassi ◽  
P Chetoni ◽  
M.P Fiaschi ◽  
Y Zambito ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Polymer Molecular Weight ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Surface Modification of Copolyether-Urethane Catheters with Poly(Ethylene Oxide)

1989 ◽  
Vol 12 (6) ◽  
pp. 390-394 ◽  
Author(s):  
E. Brinkman ◽  
A. Poot ◽  
T. Beugeling ◽  
L. Van Der Does ◽  
A. Bantjes
Keyword(s):  
Surface Modification ◽  
Ethylene Oxide ◽  
Blood Compatibility ◽  
Angle Measurements ◽  
Fold Reduction ◽  
Contact Angle Measurements ◽  
Platelet Deposition ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Pellethane 2363 80A catheters were modified with poly(ethylene oxide) in order to improve their blood compatibility. Contact angle measurements showed that Pellethane 2363 80A surfaces had increased wettability after this modification. The results of in vitro blood compatibility tests showed that surface modification with poly(ethylene oxide) resulted in a five-fold reduction of platelet deposition. Activation of coagulation was not affected.

In vitro and in vivo antifungal activity and preliminary mechanism of cembratrien-diols against Botrytis cinerea

2020 ◽  
Vol 154 ◽  
pp. 112745
Author(s):  
Qiong Yang ◽  
Jiao Wang ◽  
Peng Zhang ◽  
Shengnan Xie ◽  
Xiaolong Yuan ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Botrytis Cinerea ◽  
In Vivo Antifungal Activity
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