Crystal Landscape of Chiral Drug Chlorphenesin and Its Structural Analogues: Polymorphism of Racemic and Enantiopure Samples, Metastable and Stable Racemic Conglomerates, Diverse in Unity Crystal Motifs

2021 ◽  
Author(s):  
Alexander A. Bredikhin ◽  
Dmitry V. Zakharychev ◽  
Aidar T. Gubaidullin ◽  
Aida I. Samigullina ◽  
Zemfira A. Bredikhina
Keyword(s):  
Chiral Drug ◽  
Structural Analogues

The Application of Molecularly Imprinted Polymers to Solid-Phase Extraction

2014 ◽  
Vol 893 ◽  
pp. 283-286
Author(s):  
Hong Ying Pei ◽  
Gui Jun Shen ◽  
Yu Du
Keyword(s):  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymers ◽  
Biological Samples ◽  
Solid Phase ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Structural Analogues ◽  
Environmental And Biological Samples

A benefit of imprinted polymers is the possibility to prepare sorbents with selectivity pre-determined for a particular substance, or group of structural analogues. The application most close to a wider acceptance is probably that of solid phase extraction for clean-up of environmental and biological samples. The technique of molecularly imprinted polymers to solid phase extraction (MISPE) is performance and high selectively, compared with traditional sorbents. In this paper, the preparation and application of MIPs would be reviewed.

The Effect of Practolol, In Vitro Generated Metabolites of Practolol and Chemical Analogues on the Rate of Growth of Human Skin Fibroblasts

1984 ◽  
Vol 12 (2) ◽  
pp. 89-97
Author(s):  
Graham R. Elliott ◽  
H.E. Amos ◽  
James W. Bridges
Keyword(s):  
Human Skin ◽  
Psoriasis Patient ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Cell Type ◽  
Normal Human Skin ◽  
Rate Of Growth ◽  
Structural Analogues ◽  
Normal Human

The rate of growth of normal human skin fibroblasts was inhibited in a dose related, reversible, fashion by practolol (N-4-(2-hydroxy)-3 (1-methyl)-aminopropoxyphenylacetamine) (ID50 1.35 ± 0.14 x 10-3M), propranolol (1-(isopropylamino)-3(1-naphthyl-oxy)-2-propranolol) (ID50 0.145 ± 0.02 x 10-3M) and paracetamol (N-(4-hydroxyphenyl) acetamide) (ID50 0.85 ± 0.2 x 10-3M). Skin fibroblasts isolated from a psoriasis patient were more sensitive towards practolol (ID50 0.48 ± 0.14 x 10-3M) and propranolol (ID50 0.032 ± 0.002 x 10-3M), but less sensitive towards paracetamol (ID50 1.3 ± 0.07 x 10-3M). In vitro generated metabolites of practolol, using normal or Arochlor 1254-pretreated hamster liver preparations, and structural analogues of practolol had no effect upon the growth of either cell type.

Synthesis, molecular modeling study, preliminary antibacterial, and antitumor evaluation of N-substituted naphthalimides and their structural analogues

2012 ◽  
Vol 22 (5) ◽  
pp. 2360-2375 ◽  
Author(s):  
Adel S. El-Azab ◽  
Amer M. Alanazi ◽  
Naglaa I. Abdel-Aziz ◽  
Ibrahim A. Al-Suwaidan ◽  
Magda A. A. El-Sayed ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Molecular Modeling Study ◽  
Structural Analogues ◽  
Antitumor Evaluation ◽  
Modeling Study

ChemInform Abstract: Improved Synthesis of Structural Analogues of (-)-Epicatechin Gallate for Modulation of Staphylococcal β-Lactam Resistance.

ChemInform ◽  
2014 ◽  
Vol 45 (43) ◽  
pp. no-no
Author(s):  
James C. Anderson ◽  
Helen Grounds ◽  
Suzanna Reeves ◽  
Peter W. Taylor
Keyword(s):  
Epicatechin Gallate ◽  
Structural Analogues

Octacidomycine, III: Synthetische Strukturanaloga aus C5-Bausteinen / Octacidomycins, III: Synthetic Structural Analogues from C5-Units

1995 ◽  
Vol 50 (10) ◽  
pp. 1550-1556
Author(s):  
Andreas Krause ◽  
Helmut Lackner
Keyword(s):  
Total Synthesis ◽  
Tetracarboxylic Acid ◽  
Unknown Type ◽  
Structural Analogues

The total synthesis of an isoprenoid-like analogue (2) of octacidomycin (1). a novel oligocarboxylic acid antibiotic, is described. Starting from 3 (Scheme 1) and the tetraethylester of 1,11-dibromoundecane-4,4,8,8,-tetracarboxylic acid (6) as a key compound systematical fragment condensations lead to the pentadeccicarboxylic acid 12 and hence to the 1,3,7,11,15,19,23,27-heptacosane-octacarboxylic acid 2. This contains regularly connected C5- instead of C7-units and shows contracted distances between the acid groups. The newly developed synthesis yields a hitherto unknown type of oligocarboxylic acids and some useful intermediates with one or two terminal vinylic functions (13-15 ).

Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

2001 ◽  
Vol 11 (15) ◽  
pp. 1985-1988 ◽  
Author(s):  
Yoshitomo Suhara ◽  
Shinji Nakane ◽  
Shunsuke Arai ◽  
Hiroaki Takayama ◽  
Keizo Waku ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Biological Activities ◽  
Receptor Ligand ◽  
Structural Analogues ◽  
Endogenous Cannabinoid
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