Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice

2021 ◽  
Author(s):  
Hua Guo ◽  
Jiamiao Chen ◽  
Hongxia Zhang ◽  
Jingzhi Yao ◽  
Nan Sheng ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Male Mice ◽  
Hepatic Bile

Capsaicin improves glucose homeostasis by enhancing glucagon‐like peptide‐1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice

2020 ◽  
Vol 34 (6) ◽  
pp. 8558-8573 ◽  
Author(s):  
Suocheng Hui ◽  
Li Huang ◽  
Xiaolan Wang ◽  
Xiaohui Zhu ◽  
Min Zhou ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Glucose Homeostasis ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Male Mice ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism

FEBS Journal ◽  
2020 ◽  
Vol 287 (15) ◽  
pp. 3328-3345
Author(s):  
Wen‐Jun Jia ◽  
Qiao‐Li Tang ◽  
Shan Jiang ◽  
Shi‐Quan Sun ◽  
Bin Xue ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Geranylgeranyl Diphosphate Synthase ◽  
Geranylgeranyl Diphosphate ◽  
Hepatic Bile ◽  
Cholestatic Liver Injury

scholarly journals Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3200
Author(s):  
Mira J. Pauly ◽  
Julia K. Rohde ◽  
Clara John ◽  
Ioannis Evangelakos ◽  
Anja Christina Koop ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Plasma Cholesterol ◽  
Cold Treatment ◽  
Short Chain Fatty Acids ◽  
Liver Cholesterol ◽  
Bile Acid Metabolism ◽  
Short Term ◽  
Hepatic Bile ◽  
Brown Adipose

Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent studies suggest that long-term supplementation with fibers causes changes in hepatic bile acid metabolism, hepatocyte damage, and hepatocellular cancer in dysbiotic mice. Alterations in hepatic bile acid metabolism have also been reported after cold-induced activation of brown adipose tissue. Here, we aim to investigate the effects of short-term dietary inulin supplementation on liver cholesterol and bile acid metabolism in control and cold housed specific pathogen free wild type (WT) mice. We found that short-term inulin feeding lowered plasma cholesterol levels and provoked cholestasis and mild liver damage in WT mice. Of note, inulin feeding caused marked perturbations in bile acid metabolism, which were aggravated by cold treatment. Our studies indicate that even relatively short periods of inulin consumption in mice with an intact gut microbiome have detrimental effects on liver metabolism and function.

Novel β-catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis

Hepatology ◽  
2018 ◽  
Vol 67 (3) ◽  
pp. 829-832
Author(s):  
Laurent Ehrlich ◽  
Shannon S. Glaser
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Farnesoid X Receptor ◽  
Receptor Interaction ◽  
Bile Acid Metabolism ◽  
Hepatic Bile

scholarly journals FGF15/FGFR4 Integrates Growth Factor Signaling with Hepatic Bile Acid Metabolism and Insulin Action

2009 ◽  
Vol 284 (17) ◽  
pp. 11110-11120 ◽  
Author(s):  
Dong-Ju Shin ◽  
Timothy F. Osborne
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Insulin Action ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Growth Factor Signaling ◽  
Hepatic Bile

scholarly journals Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile.

1988 ◽  
Vol 263 (32) ◽  
pp. 16637-16644 ◽  
Author(s):  
K D Setchell ◽  
R Dumaswala ◽  
C Colombo ◽  
M Ronchi
Keyword(s):  
Bile Acid ◽  
Early Development ◽  
Acid Metabolism ◽  
Gallbladder Bile ◽  
Bile Acid Metabolism ◽  
Hepatic Bile

scholarly journals Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice

2017 ◽  
Vol 3 (2) ◽  
pp. 261-271 ◽  
Author(s):  
Anne S. Henkel ◽  
Brian LeCuyer ◽  
Shantel Olivares ◽  
Richard M. Green
Keyword(s):  
Endoplasmic Reticulum ◽  
Bile Acid ◽  
Endoplasmic Reticulum Stress ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Hepatic Bile

A nontumorigenic variant of FGF19 treats cholestatic liver diseases

2014 ◽  
Vol 6 (247) ◽  
pp. 247ra100-247ra100 ◽  
Author(s):  
Jian Luo ◽  
Brian Ko ◽  
Michael Elliott ◽  
Mei Zhou ◽  
Darrin A. Lindhout ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Diseases ◽  
Acid Metabolism ◽  
Prolonged Exposure ◽  
Surrogate Marker ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Metabolism ◽  
Hepatic Bile ◽  
Healthy Human

Hepatic accumulation of bile acids is central to the pathogenesis of cholestatic liver diseases. Endocrine hormone fibroblast growth factor 19 (FGF19) may reduce hepatic bile acid levels through modulation of bile acid synthesis and prevent subsequent liver damage. However, FGF19 has also been implicated in hepatocellular carcinogenesis, and consequently, the potential risk from prolonged exposure to supraphysiological levels of the hormone represents a major hurdle for developing an FGF19-based therapy. We describe a nontumorigenic FGF19 variant, M70, which regulates bile acid metabolism and, through inhibition of bile acid synthesis and reduction of excess hepatic bile acid accumulation, protects mice from liver injury induced by either extrahepatic or intrahepatic cholestasis. Administration of M70 in healthy human volunteers potently reduces serum levels of 7α-hydroxy-4-cholesten-3-one, a surrogate marker for the hepatic activity of cholesterol 7α-hydroxylase (CYP7A1), the enzyme responsible for catalyzing the first and rate-limiting step in the classical bile acid synthetic pathway. This study provides direct evidence for the regulation of bile acid metabolism by FGF19 pathway in humans. On the basis of these results, the development of nontumorigenic FGF19 variants capable of modulating CYP7A1 expression represents an effective approach for the prevention and treatment of cholestatic liver diseases as well as potentially for other disorders associated with bile acid dysregulation.

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