Occurrence and Maternal Transfer of Chlorinated Bisphenol A and Nonylphenol in Pregnant Women and Their Matching Embryos

2015 ◽  
Vol 50 (2) ◽  
pp. 970-977 ◽  
Author(s):  
Mo Chen ◽  
Zhanlan Fan ◽  
Fanrong Zhao ◽  
Fumei Gao ◽  
Di Mu ◽  
...  
2019 ◽  
Vol 47 (7) ◽  
pp. 765-770 ◽  
Author(s):  
Monika Zbucka-Krętowska ◽  
Urszula Łazarek ◽  
Wojciech Miltyk ◽  
Iwona Sidorkiewicz ◽  
Piotr Pierzyński ◽  
...  

Abstract Background Bisphenol A (BPA) is an estrogenic, endocrine-disrupting compound widely used in the industry. It is also a ubiquitous environmental pollutant. Its presence was confirmed in human fetuses, which results from maternal exposure during pregnancy. The mechanisms behind maternal-fetal transfer, and relationships between pregnant women and fetal exposures remain unclear. The aim of this study was to assess the impact of maternal exposure to BPA on the exposure of the fetus. Methods Maternal plasma and amniotic fluid samples were collected from 52 pregnant women undergoing amniocentesis for prenatal diagnosis of chromosomal abnormalities. BPA was measured by gas chromatography-mass spectrometry (GC-MS). The permeability factor – a ratio of fetal-to-maternal BPA concentration – was used as a measure delineating the transplacental transfer of BPA. Results The median concentration of maternal plasma BPA was 8 times higher than the total BPA concentration in the amniotic fluid (8.69 ng/mL, range: 4.3 ng/mL–55.3 ng/mL vs. median 1.03 ng/mL, range: 0.3 ng/mL–10.1 ng/mL). There was no direct relationship between the levels of BPA in maternal plasma and amniotic fluid levels. The permeability factor, in turn, negatively correlated with fetal development (birth weight) (R = −0.54, P < 0.001). Conclusion Our results suggest that the risk of fetal BPA exposure depends on placental BPA permeability rather than the levels of maternal BPA plasma concentration and support general recommendations to become aware and avoid BPA-containing products.


2013 ◽  
Vol 59 ◽  
pp. 152-160 ◽  
Author(s):  
Lesliam Quirós-Alcalá ◽  
Brenda Eskenazi ◽  
Asa Bradman ◽  
Xiaoyun Ye ◽  
Antonia M. Calafat ◽  
...  

2013 ◽  
Vol 2013 (1) ◽  
pp. 4742
Author(s):  
Janet Pan ◽  
Ami Zota ◽  
Carrie Dickenson ◽  
Tracey Woodruff ◽  
Roy Gerona ◽  
...  

2015 ◽  
Vol 123 (4) ◽  
pp. 277-284 ◽  
Author(s):  
Tye E. Arbuckle ◽  
Leonora Marro ◽  
Karelyn Davis ◽  
Mandy Fisher ◽  
Pierre Ayotte ◽  
...  
Keyword(s):  

2017 ◽  
Vol 102 (4) ◽  
pp. 1350-1357 ◽  
Author(s):  
Yu-Han Chiu ◽  
Lidia Mínguez-Alarcón ◽  
Jennifer B. Ford ◽  
Myra Keller ◽  
Ellen W. Seely ◽  
...  

2015 ◽  
Vol 168 ◽  
pp. 11-18 ◽  
Author(s):  
Oana Birceanu ◽  
Trinh Mai ◽  
Mathilakath M. Vijayan

2016 ◽  
Vol 92 ◽  
pp. 129-142 ◽  
Author(s):  
Justin G. Teeguarden ◽  
Nathan C. Twaddle ◽  
Mona I. Churchwell ◽  
Daniel R. Doerge

2013 ◽  
Vol 216 (6) ◽  
pp. 641-644 ◽  
Author(s):  
Anna Carita Callan ◽  
Andrea Lee Hinwood ◽  
Amy Heffernan ◽  
Geoff Eaglesham ◽  
Jochen Mueller ◽  
...  
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