Biases Arising from the Use of Ambient Measurements to Represent Personal Exposure in Evaluating Inflammatory Responses to Fine Particulate Matter: Evidence from a Panel Study in Beijing, China

2020 ◽  
Vol 7 (10) ◽  
pp. 746-752
Author(s):  
Yunfei Fan ◽  
Yiqun Han ◽  
Yingjun Liu ◽  
Yanwen Wang ◽  
Xi Chen ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Inflammatory Responses ◽  
Fine Particulate Matter ◽  
Panel Study ◽  
Personal Exposure ◽  
Fine Particulate ◽  
Ambient Measurements ◽  
Beijing China

Personal exposure to fine particulate matter and renal function in children: A panel study

2020 ◽  
Vol 266 ◽  
pp. 115129
Author(s):  
Miao Liu ◽  
Wenting Guo ◽  
Yunyao Cai ◽  
Huihua Yang ◽  
Wenze Li ◽  
...  
Keyword(s):  
Renal Function ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Panel Study ◽  
Personal Exposure ◽  
Fine Particulate

scholarly journals Regulatory T Cells Protect Fine Particulate Matter-Induced Inflammatory Responses in Human Umbilical Vein Endothelial Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Wen-cai Zhang ◽  
Yan-ge Wang ◽  
Zheng-feng Zhu ◽  
Fang-qin Wu ◽  
Yu-dong Peng ◽  
...  
Keyword(s):  
T Cells ◽  
Endothelial Cells ◽  
Particulate Matter ◽  
Inflammatory Cytokines ◽  
Fine Particles ◽  
Inflammatory Responses ◽  
Umbilical Vein ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
Umbilical Vein Endothelial Cells

Objective. To investigate the role of CD4+CD25+T cells (Tregs) in protecting fine particulate matter (PM-) induced inflammatory responses, and its potential mechanisms.Methods. Human umbilical vein endothelial cells (HUVECs) were treated with graded concentrations (2, 5, 10, 20, and 40 µg/cm2) of suspension of fine particles for 24h. For coculture experiment, HUVECs were incubated alone, with CD4+CD25−T cells (Teff), or with Tregs in the presence of anti-CD3 monoclonal antibodies for 48 hours, and then were stimulated with or without suspension of fine particles for 24 hours. The expression of adhesion molecules and inflammatory cytokines was examined.Results. Adhesion molecules, including vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), and inflammatory cytokines, such as interleukin (IL-) 6 and IL-8, were increased in a concentration-dependent manner. Moreover, the adhesion of human acute monocytic leukemia cells (THP-1) to endothelial cells was increased and NF-κB activity was upregulated in HUVECs after treatment with fine particles. However, after Tregs treatment, fine particles-induced inflammatory responses and NF-κB activation were significantly alleviated. Transwell experiments showed that Treg-mediated suppression of HUVECs inflammatory responses impaired by fine particles required cell contact and soluble factors.Conclusions. Tregs could attenuate fine particles-induced inflammatory responses and NF-κB activation in HUVECs.

scholarly journals Measuring personal exposure to fine particulate matter (PM2.5) among rural Honduran women: A field evaluation of the Ultrasonic Personal Aerosol Sampler (UPAS)

2019 ◽  
Vol 123 ◽  
pp. 50-53 ◽  
Author(s):  
Ajay Pillarisetti ◽  
Ellison Carter ◽  
Sarah Rajkumar ◽  
Bonnie N. Young ◽  
Megan L. Benka-Coker ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Field Evaluation ◽  
Personal Exposure ◽  
Fine Particulate
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