scholarly journals Measurement of Saccharin and trans-Resveratrol Metabolites in Urine as Adherence Markers for Small Quantity Lipid-Based Nutrient Supplement Consumption

2021 ◽  
Vol 69 (3) ◽  
pp. 1107-1114
Author(s):  
Valerie Weinborn ◽  
Arlie L. Lehmkuhler ◽  
Sarah J. Zyba ◽  
Marjorie J. Haskell ◽  
Fanny B. Morel ◽  
...  
Keyword(s):  
2012 ◽  
Vol 82 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Salah E. Gariballa ◽  
Sarah J. Forster ◽  
Hilary J. Powers

Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B2, 1.4 mg of vitamin B6, 1.5 μg of B12, 200 μg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 µmol/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 µmol/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (>14 µmol/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness.


2021 ◽  
Vol 9 (5) ◽  
pp. 1053
Author(s):  
Gonzalo Martinez-Fernandez ◽  
Jinzhen Jiao ◽  
Jagadish Padmanabha ◽  
Stuart E. Denman ◽  
Christopher S. McSweeney

We have found one inadvertent error in our paper published in Microorganisms [...]


2018 ◽  
Vol Volume 11 ◽  
pp. 195-201 ◽  
Author(s):  
Flavia Addor ◽  
Juliana Cotta Vieira ◽  
Camila Abreu

2004 ◽  
Vol 08 (23) ◽  
pp. 1298-1302 ◽  
Author(s):  
Krutika Desai ◽  
Subramanian Sivakami

This article is about spirulina and how it can be used as a nutrient supplement, a therapeutic agent, trace metal supplement, antioxidant, pigments, enviroment protector and a source of enzymes.


2018 ◽  
Vol 39 (2_suppl) ◽  
pp. S60-S68 ◽  
Author(s):  
Seth Adu-Afarwuah

Background: This article summarizes a presentation given at the 2017 Dairy for Global Nutrition Conference in Boise, Idaho. Objective: To give an overview of the pattern of early growth faltering in developing countries and examine the implications of the iLiNS-DYAD randomized trial in Ghana. Methods: The pattern of growth faltering in developing countries was outlined. In Ghana, 1320 women ≤ 20 weeks of pregnancy were assigned to 20 g/d small-quantity lipid-based nutrient supplement (SQ-LNS; LNS group) or multiple micronutrients (MMNs) containing 22 and 18 vitamins and minerals, respectively, until 6 months postpartum, or iron and folic acid (IFA) until delivery, and thereafter placebo until 6 months postpartum. Infants in the LNS group were assigned to SQ-LNS from 6 to 18 months of age. Results: Mean anthropometric z-scores for infants in developing countries start below the World Health Organization standard at 1 month of age, and generally decline until about age of 24 months. In the Ghana trial, mean (SD) birth weight (g) was greater ( P = .044) for the LNS group (3030 [414]) than the IFA group (2945 [442]) but not the MMN group (3005 [435]). Among primiparous mothers, the LNS group had significantly greater mean birth length, weight, and head circumference than the IFA or MMN group. By 18 months of age, the mean length (95% confidence interval) for the LNS group was +0.6 (0.1-1.1) cm greater than for the IFA group and +0.6 (0.1-1.2) cm greater than for the MMN group. Conclusion: Pre- and post-natal SQ-LNS consumption may improve fetal and infant growth in similar populations.


2018 ◽  
Vol 83 (6) ◽  
pp. 1748-1756 ◽  
Author(s):  
Shashank Gaur ◽  
Emely C. Lopez ◽  
Ankur Ojha ◽  
Juan E. Andrade

2019 ◽  
Vol 110 (6) ◽  
pp. 1476-1490 ◽  
Author(s):  
Laura Adubra ◽  
Agnes Le Port ◽  
Yves Kameli ◽  
Sonia Fortin ◽  
Tanimoune Mahamadou ◽  
...  

ABSTRACT Background In 2014, the World Food Programme added to an ongoing health and nutrition program named “Santé Nutritionnelle à Assise Communautaire dans la région de Kayes” (SNACK), the distribution of cash to mothers and/or lipid-based nutrient supplement (LNS) to children aged 6–23 mo, conditional upon attendance at community health centers (CHCs) during the first 1000 d of life. Objective We evaluated the additional impact of the distribution of cash and/or LNS on mean height-for-age z scores (HAZ; primary outcome), stunting (HAZ < −2), and on intermediate outcomes along the program impact pathways. Methods In a cluster-randomized controlled trial using a 2 × 2 factorial design, 76 CHCs were randomly assigned to deliver either SNACK, SNACK + Cash, SNACK + LNS, or SNACK + Cash + LNS. Cross-sectional surveys among 12- to 42-mo-old children and their mothers were conducted at baseline (2013, n = 5046) and at endline (2016, n = 5098). Results Factorial analysis showed no interaction between cash and LNS treatments for HAZ, but found an antagonistic interaction for stunting (OR: 1.55; 95% CI: 1.05, 2.31; P = 0.03). There were no impacts of the cash, LNS, or cash + LNS treatments, compared with the SNACK alone, on either HAZ or stunting (treatment × time interaction). There were significant impacts of the LNS and cash + LNS treatments on attendance at ≥1 growth monitoring (GM) session (OR: 3.95; 95% CI: 1.69, 9.24; OR: 3.90; 95% CI: 1.73, 8.81, respectively) and half the expected sessions (OR: 4.72; 95% CI: 1.47, 15.17; OR: 5.25; 95% CI: 1.82, 15.11, respectively), mothers’ knowledge on importance of GM (OR: 1.98; 95% CI: 1.16, 3.39; OR: 3.12; 95% CI: 1.60, 6.09, respectively), and, only for the LNS group, appropriate timing for complementary feeding (OR: 1.62; 95% CI: 1.09, 2.41). Conclusions Implementation constraints and suboptimal participation in program activities may explain the lack of impact on child linear growth in this rural region of Mali. This trial was registered at www.isrctn.com as ISRCTN08435964.


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