Discovery of Novel Chromone Derivatives as Potential Anti-TSWV Agents

Three new and rare chromone derivatives, epiremisporine C (1), epiremisporine D (2), and epiremisporine E (3), were isolated from marine-derived Penicillium citrinum, together with four known compounds, epiremisporine B (4), penicitrinone A (5), 8-hydroxy-1-methoxycarbonyl-6-methylxanthone (6), and isoconiochaetone C (7). Among the isolated compounds, compounds 2–5 significantly decreased fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 6.39 ± 0.40, 8.28 ± 0.29, 3.62 ± 0.61, and 2.67 ± 0.10 μM, respectively. Compounds 3 and 4 exhibited cytotoxic activities with IC50 values of 43.82 ± 6.33 and 32.29 ± 4.83 μM, respectively, against non-small lung cancer cell (A549), and Western blot assay confirmed that compounds 3 and 4 markedly induced apoptosis of A549 cells, through Bcl-2, Bax, and caspase 3 signaling cascades.

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Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104927 ◽

2021 ◽

pp. 104927

Author(s):

Zhi Liang ◽

Tanwei Gu ◽

Jianjiao Wang ◽

Jianglian She ◽

Yuxiu Ye ◽

...

Keyword(s):

Liver X Receptors ◽

Chromone Derivatives ◽

X Receptors ◽

Pestalotiopsis Neglecta

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Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113578 ◽

2021 ◽

pp. 113578

Author(s):

Yohei Saito ◽

Yukako Taniguchi ◽

Sachika Hirazawa ◽

Yuta Miura ◽

Hiroyuki Tsurimoto ◽

...

Keyword(s):

Chromone Derivatives ◽

Intracellular Target

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Two new 2-(2-phenethyl)chromone derivatives from agarwood of Aquilaria walla and their cytotoxicity

Phytochemistry Letters ◽

10.1016/j.phytol.2021.01.010 ◽

2021 ◽

Vol 42 ◽

pp. 36-40

Author(s):

Yue-Yue Wang ◽

Hao Wang ◽

Cheng-Neng Mi ◽

Wei Li ◽

Cui-Juan Gai ◽

...

Keyword(s):

Chromone Derivatives

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Chromone Derivatives Bearing Pyridinium Moiety as Multi-Target-Directed Ligands against Alzheimer’s disease

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104750 ◽

2021 ◽

pp. 104750

Author(s):

Shahin Abdpour ◽

Leili Jalili-Baleh ◽

Hamid Nadri ◽

Hamid Forootanfar ◽

Syed Nasir Abbas Bukhari ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Chromone Derivatives

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New Chromones from a Marine-Derived Fungus, Arthrinium sp., and Their Biological Activity

Molecules ◽

10.3390/molecules23081982 ◽

2018 ◽

Vol 23 (8) ◽

pp. 1982 ◽

Cited By ~ 5

Author(s):

Jie Bao ◽

Fei He ◽

Jin-Hai Yu ◽

Huijuan Zhai ◽

Zhi-Qiang Cheng ◽

...

Keyword(s):

Biological Activity ◽

Deep Sea ◽

Spectroscopic Data ◽

Radical Scavenging ◽

Antioxidant Property ◽

Electronic Circular Dichroism ◽

Chromone Derivatives ◽

Ic50 Values ◽

Ester Method ◽

The Absolute

Five new chromone derivatives, arthones A–E (1–5), together with eight known biogenetically related cometabolites (6–13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures were assigned by detailed analyses of spectroscopic data, while the absolute configurations of 1 and 5 were established by electronic circular dichroism (ECD) calculations and that of 2 was determined by modified Mosher ester method. Compounds 3 and 8 exhibited potent antioxidant property with DPPH and ABTS radical scavenging activities, with IC50 values ranging from 16.9 to 18.7 μM. Meanwhile, no compounds indicated obvious bioactivity in our antimicrobial and anti-inflammatory assays at 50.0 μM.

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