Inhibitory Effects of North American Wild Rice on Monocyte Adhesion and Inflammatory Modulators in Low-Density Lipoprotein Receptor-Knockout Mice

2017 ◽  
Vol 65 (41) ◽  
pp. 9054-9060 ◽  
Author(s):  
Mohammed H. Moghadasian ◽  
Ruozhi Zhao ◽  
Nora Ghazawwi ◽  
Khuong Le ◽  
Franklin B. Apea-Bah ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Wild Rice ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Monocyte Adhesion ◽  
Inhibitory Effects ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor

scholarly journals Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice

2009 ◽  
Vol 51 (5) ◽  
pp. 900-906 ◽  
Author(s):  
Eric D. Bischoff ◽  
Chris L. Daige ◽  
Mary Petrowski ◽  
Harry Dedman ◽  
Jennifer Pattison ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor

scholarly journals Anti-Atherosclerotic Properties of Wild Rice in Low-Density Lipoprotein Receptor Knockout Mice: The Gut Microbiome, Cytokines, and Metabolomics Study

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2894 ◽  
Author(s):  
Mohammed H. Moghadasian ◽  
Ramandeep Kaur ◽  
Kayla Kostal ◽  
Akhila A. Joshi ◽  
Mahboubeh Molaei ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Wild Rice ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Plasma Samples ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor ◽  
And Control

Background and aim: We previously reported the anti-atherogenic properties of wild rice in low-density lipoprotein receptor knockout (LDL-r-KO) mice. The present study aimed to discover the mechanism of action for such effects. Materials: Fecal and plasma samples from the wild rice treated and control mice were used. Fecal bacterial population was estimated while using 16S rDNA technology. The plasma samples were used to estimate the levels of 35 inflammatory markers and metabolomics, while using Meso Scale multiplex assay and liquid chromatography-mass spectrometry (LC-MS/MS) techniques. Results: Many bacteria, particularly Anaeroplasma sp., Acetatifactor sp., and Prophyromonadaceae sp., were found in higher quantities in the feces of wild rice fed mice as compared to the controls. Cytokine profiles were significantly different between the plasma of treated and control mice. Among them, an increase in the level of IL-10 and erythropoietin (EPO) could explain the anti-atherogenic properties of wild rice. Among many metabolites tested in plasma of these animals, surprisingly, we found an approximately 60% increase in the levels of glucose in the wild rice fed mice as compared to that in the control mice. Conclusion: Additional studies warrant further investigation of the interplay among gut microbiome, inflammatory status, and macronutrient metabolism.

Dietary corn fractions reduce atherogenesis in low-density lipoprotein receptor knockout mice

2017 ◽  
Vol 37 ◽  
pp. 87-96 ◽  
Author(s):  
Kabo Masisi ◽  
Khuong Le ◽  
Nora Ghazzawi ◽  
Mohammed H. Moghadasian ◽  
Trust Beta
Keyword(s):  
Knockout Mice ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Low Density Lipoprotein Receptor ◽  
Density Lipoprotein Receptor
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