Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold

Selective Inhibitors

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b00838 ◽

2018 ◽

Vol 61 (18) ◽

pp. 8299-8320 ◽

Cited By ~ 15

Author(s):

Benjamin J. Buckley ◽

Ashraf Aboelela ◽

Elahe Minaei ◽

Longguang X. Jiang ◽

Zhihong Xu ◽

...

Keyword(s):

Plasminogen Activator ◽

Selective Inhibitors ◽

Hexamethylene Amiloride

Soluble urokinase plasminogen activator receptor is a marker for severity of liver fibrosis in hepatitis C infection

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1263888 ◽

2010 ◽

Vol 48 (08) ◽

Author(s):

ML Berres ◽

B Schlosser ◽

T Berg ◽

C Trautwein ◽

HE Wasmuth

Keyword(s):

Hepatitis C ◽

Liver Fibrosis ◽

Plasminogen Activator ◽

Hepatitis C Infection ◽

The role of soluble urokinase plasminogen activator receptor as an early biomarker of severity and organ failure in patients with acute pancreatitis

10.26226/morressier.57c5383fd462b80296c9bd2a ◽

2016 ◽

Author(s):

Amir Soleimani

Keyword(s):

Acute Pancreatitis ◽

Organ Failure ◽

Plasminogen Activator ◽

Early Biomarker ◽

Faculty Opinions recommendation of RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1029099.342534 ◽

2005 ◽

Author(s):

Richard L Stevens

Keyword(s):

Prostate Cancer ◽

Rna Interference ◽

Plasminogen Activator ◽

Cell Invasion ◽

Prostate Cancer Cell ◽

Cancer Cell Invasion ◽

Faculty Opinions recommendation of Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1033797.388968 ◽

2006 ◽

Author(s):

Arthur Frankel

Keyword(s):

Growth Factor ◽

Tumor Growth ◽

Pancreatic Carcinoma ◽

Plasminogen Activator ◽

Carcinoma Cells ◽

Migration And Invasion ◽

Factor I ◽

Faculty Opinions recommendation of Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1053811.505747 ◽

2006 ◽

Author(s):

Lindsey A Miles

Keyword(s):

Crystal Structure ◽

Plasminogen Activator ◽

Soluble urokinase plasminogen activator receptor as a decision marker for early discharge of patients with COVID-19 symptoms in the emergency department

Journal of Emergency Medicine ◽

10.1016/j.jemermed.2021.03.012 ◽

2021 ◽

Author(s):

Marius Ahm Stauning ◽

Izzet Altintas ◽

Thomas Kallemose ◽

Jesper Eugen-Olsen ◽

Mette Bendtz Lindstrøm ◽

...

Keyword(s):

Emergency Department ◽

Plasminogen Activator ◽

Early Discharge ◽

Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer

EJNMMI Research ◽

10.1186/s13550-020-00673-7 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

V. M. Baart ◽

R. D. Houvast ◽

L. F. de Geus-Oei ◽

P. H. A. Quax ◽

P. J. K. Kuppen ◽

...

Keyword(s):

Molecular Imaging ◽

Plasminogen Activator ◽

Elevated levels of soluble urokinase plasminogen activator receptor as a low-grade inflammation marker in schizophrenia: A case-control study

Schizophrenia Research ◽

10.1016/j.schres.2020.11.051 ◽

2021 ◽

Vol 228 ◽

pp. 190-192

Author(s):

Therese Torgersen Bigseth ◽

Mats Fredriksen ◽

Jens Egeland ◽

Eivind Andersen ◽

Ole Andreas Andreassen ◽

...

Keyword(s):

Plasminogen Activator ◽

Case Control Study ◽

Case Control ◽

Low Grade ◽

Inflammation Marker ◽

Plasminogen Activator Receptor ◽

Low Grade Inflammation ◽

Control Study

Correlation of Serum and Ascitic Fluid Soluble Form Urokinase Plasminogen Activator Receptor Levels With Patient Complications, Disease Severity, Inflammatory Markers, and Prognosis in Patients With Severe Acute Pancreatitis

Pancreas ◽

10.1097/mpa.0000000000001247 ◽

2019 ◽

Vol 48 (3) ◽

pp. 335-342 ◽

Cited By ~ 1

Author(s):

Ding Long ◽

Yujun Wang ◽

Hui Wang ◽

Xiaoling Wu ◽

Li Yu

Keyword(s):

Acute Pancreatitis ◽

Plasminogen Activator ◽

Disease Severity ◽

Ascitic Fluid ◽

Severe Acute Pancreatitis ◽

Inflammatory Markers ◽

Soluble Form ◽