Binding of Fatty Acid Amide Amphiphiles to Bovine Serum Albumin: Role of Amide Hydrogen Bonding

This article focuses on the vital role of hydrogen bonding to explain unusual photophysical behaviours (sensing BSA, pH probing, specific solvent effect) of an ‘Aggregation-induced Emission’ (AIE) active Ir(iii) complex.

Download Full-text

Role of hydrogen-bonding and photoinduced electron transfer (PET) on the interaction of resorcinol based acridinedione dyes with Bovine Serum Albumin (BSA) in water

Journal of Luminescence ◽

10.1016/j.jlumin.2015.03.010 ◽

2015 ◽

Vol 164 ◽

pp. 146-153 ◽

Cited By ~ 13

Author(s):

Rajendran Kumaran ◽

Mahalingam Vanjinathan ◽

Perumal Ramamurthy

Keyword(s):

Electron Transfer ◽

Hydrogen Bonding ◽

Bovine Serum Albumin ◽

Serum Albumin ◽

Photoinduced Electron Transfer ◽

Bovine Serum ◽

Acridinedione Dyes

Download Full-text

Role of pH on Adsorption of Bovine Serum Albumin Protein Capsules to Surfaces

Current Proteomics ◽

10.2174/157016461203151120093820 ◽

2015 ◽

Vol 12 (3) ◽

pp. 185-193

Author(s):

Kamatchi Sankaranarayanan

Keyword(s):

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Bovine Serum Albumin Protein

Download Full-text

Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review

International Journal of Molecular Sciences ◽

10.3390/ijms22031047 ◽

2021 ◽

Vol 22 (3) ◽

pp. 1047

Author(s):

Dorsa Rafiei ◽

Nathan J. Kolla

Keyword(s):

Depressive Symptoms ◽

Fatty Acid ◽

Animal Models ◽

Fatty Acid Amide Hydrolase ◽

Acid Amide ◽

Endocannabinoid System ◽

Animal Models Of Depression ◽

Amide Hydrolase ◽

Fatty Acid Amide

Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several neuropsychiatric disorders, including major depressive disorder (MDD). It is speculated that increased brain FAAH expression is correlated with increased depressive symptoms. The aim of this scoping review was to establish the role of FAAH expression in animal models of depression to determine the translational potential of targeting FAAH in clinical studies. A literature search employing multiple databases was performed; all original articles that assessed FAAH expression in animal models of depression were considered. Of the 216 articles that were screened for eligibility, 24 articles met inclusion criteria and were included in this review. Three key findings emerged: (1) FAAH expression is significantly increased in depressive-like phenotypes; (2) genetic knockout or pharmacological inhibition of FAAH effectively reduces depressive-like behavior, with a dose-dependent effect; and (3) differences in FAAH expression in depressive-like phenotypes were largely localized to animal prefrontal cortex, hippocampus and striatum. We conclude, based on the animal literature, that a positive relationship can be established between brain FAAH level and expression of depressive symptoms. In summary, we suggest that FAAH is a tractable target for developing novel pharmacotherapies for MDD.

Download Full-text