Binding of Fatty Acid Amide Amphiphiles to Bovine Serum Albumin: Role of Amide Hydrogen Bonding

2015 ◽  
Vol 119 (25) ◽  
pp. 7804-7815 ◽  
Author(s):  
Subhajit Ghosh ◽  
Joykrishna Dey
Keyword(s):  
Hydrogen Bonding ◽  
Fatty Acid ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Acid Amide ◽  
Amide Hydrogen ◽  
Fatty Acid Amide

A multistimuli responsive heteroleptic iridium(iii) complex: role of hydrogen bonding in probing solvent, pH and bovine serum albumin (BSA)

2020 ◽  
Vol 8 (19) ◽  
pp. 6605-6614
Author(s):  
Vishal Kachwal ◽  
Parva Kumar Sharma ◽  
Amrit Sarmah ◽  
Shibasish Chowdhury ◽  
Inamur Rahaman Laskar
Keyword(s):  
Hydrogen Bonding ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Solvent Effect ◽  
Bovine Serum ◽  
Vital Role ◽  
Aggregation Induced Emission

This article focuses on the vital role of hydrogen bonding to explain unusual photophysical behaviours (sensing BSA, pH probing, specific solvent effect) of an ‘Aggregation-induced Emission’ (AIE) active Ir(iii) complex.

scholarly journals Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review

2021 ◽  
Vol 22 (3) ◽  
pp. 1047
Author(s):  
Dorsa Rafiei ◽  
Nathan J. Kolla
Keyword(s):  
Depressive Symptoms ◽  
Fatty Acid ◽  
Animal Models ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Endocannabinoid System ◽  
Animal Models Of Depression ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several neuropsychiatric disorders, including major depressive disorder (MDD). It is speculated that increased brain FAAH expression is correlated with increased depressive symptoms. The aim of this scoping review was to establish the role of FAAH expression in animal models of depression to determine the translational potential of targeting FAAH in clinical studies. A literature search employing multiple databases was performed; all original articles that assessed FAAH expression in animal models of depression were considered. Of the 216 articles that were screened for eligibility, 24 articles met inclusion criteria and were included in this review. Three key findings emerged: (1) FAAH expression is significantly increased in depressive-like phenotypes; (2) genetic knockout or pharmacological inhibition of FAAH effectively reduces depressive-like behavior, with a dose-dependent effect; and (3) differences in FAAH expression in depressive-like phenotypes were largely localized to animal prefrontal cortex, hippocampus and striatum. We conclude, based on the animal literature, that a positive relationship can be established between brain FAAH level and expression of depressive symptoms. In summary, we suggest that FAAH is a tractable target for developing novel pharmacotherapies for MDD.

Role of bovine serum albumin and humic acid in the interaction between SiO2 nanoparticles and model cell membranes

2016 ◽  
Vol 219 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaoran Wei ◽  
Xiaolei Qu ◽  
Lei Ding ◽  
Jingtian Hu ◽  
Wei Jiang
Keyword(s):  
Humic Acid ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Cell Membranes ◽  
Sio2 Nanoparticles ◽  
Model Cell

scholarly journals Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors

2017 ◽  
Vol 174 (21) ◽  
pp. 3837-3847 ◽  
Author(s):  
Erin M Rock ◽  
Guillermo Moreno-Sanz ◽  
Cheryl L Limebeer ◽  
Gavin N Petrie ◽  
Roberto Angelini ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Animal Models ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Cb1 Receptors ◽  
Anticipatory Nausea ◽  
Amide Hydrolase ◽  
Fatty Acid Amide

Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress

2014 ◽  
Vol 24 (9) ◽  
pp. 1511-1523 ◽  
Author(s):  
Gaurav Bedse ◽  
Roberto Colangeli ◽  
Angelo M. Lavecchia ◽  
Adele Romano ◽  
Fabio Altieri ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hpa Axis ◽  
Basolateral Amygdala ◽  
Fatty Acid Amide Hydrolase ◽  
Acid Amide ◽  
Response To Stress ◽  
Amide Hydrolase ◽  
Fatty Acid Amide
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