Analyzing the Effect of Substituents on the Photophysical Properties of Carbazole-Based Two-Photon Fluorescent Probes for Hypochlorite in Mitochondria

Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs regulate many physiological processes. They recently attracted attention after extensive studies showed their involvement in metabolic disorders and diseases such as obesity, diabetes, and cancer. Therefore, it is of the highest importance to have reliable imaging tools. In this review, we focus on recent advances in the development of selective fluorescent probes for LDs. Their photophysical properties are described, and their advantages and drawbacks in fluorescence imaging are discussed. At last, we review the reported applications using these probes including two-photon excitation, in vivo and tissue imaging, as well as LDs tracking.

Download Full-text

Two-Photon Fluorescent Probes for Detecting Enzyme Activities in Live Tissues

ACS Applied Bio Materials ◽

10.1021/acsabm.1c00063 ◽

2021 ◽

Author(s):

Vinayak Juvekar ◽

Hyo Won Lee ◽

Hwan Myung Kim

Keyword(s):

Fluorescent Probes ◽

Enzyme Activities ◽

Two Photon

Download Full-text

Polarity-active NIR probes with strong two-photon absorption and ultrahigh binding affinity of insulin amyloid fibrils

Chemical Science ◽

10.1039/d0sc03907a ◽

2021 ◽

Author(s):

Li Li ◽

Zheng Lv ◽

Zhongwei Man ◽

Zhenzhen Xu ◽

YuLing Wei ◽

...

Keyword(s):

Neurodegenerative Diseases ◽

Binding Affinity ◽

Fluorescent Probes ◽

Amyloid Fibrils ◽

Photon Absorption ◽

Two Photon Absorption ◽

Two Photon ◽

Medical Diagnostic

Amyloid fibrils are associated with many neurodegenerative diseases. In-situ and in-vivo visualization of amyloid fibrils is important for medical diagnostic and requires fluorescent probes with both excitation and emission wavelengths in...

Download Full-text

NIR-region two-photon fluorescent probes for Fe3+/Cu2+ ions based on pyrimidine derivatives with different flexible chain

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2015.08.079 ◽

2016 ◽

Vol 222 ◽

pp. 574-578 ◽

Cited By ~ 11

Author(s):

Qiong Zhang ◽

Xiaohe Tian ◽

Hui Wang ◽

Zhangjun Hu ◽

Jieying Wu ◽

...

Keyword(s):

Fluorescent Probes ◽

Pyrimidine Derivatives ◽

Flexible Chain ◽

Two Photon

Download Full-text

Theoretical investigation and design of two-photon fluorescent probes for visualizing β-galactosidase activity in living cells

RSC Advances ◽

10.1039/c6ra11712k ◽

2016 ◽

Vol 6 (75) ◽

pp. 70960-70971 ◽

Cited By ~ 1

Author(s):

Chun Zhang ◽

Dan Wang ◽

Li Zhang ◽

Jing-Fu Guo ◽

Ai-Min Ren

Keyword(s):

Theoretical Investigation ◽

Fluorescent Probes ◽

Living Cells ◽

Galactosidase Activity ◽

Two Photon ◽

Bio Imaging

The two-photon fluorescent probes show dual signal for β-gal bio-imaging.

Download Full-text

Two-Photon Fluorescent Probes for Metal Ions in Live Tissues

Inorganic Chemistry ◽

10.1021/ic402475f ◽

2013 ◽

Vol 53 (4) ◽

pp. 1794-1803 ◽

Cited By ~ 59

Author(s):

Avik Ranjan Sarkar ◽

Dong Eun Kang ◽

Hwan Myung Kim ◽

Bong Rae Cho

Keyword(s):

Metal Ions ◽

Fluorescent Probes ◽

Two Photon

Download Full-text

Effect of substituents on absorption and fluorescence properties of pyrazolo[3,4-b]pyrrolo[2,3-d]pyridines

Canadian Journal of Chemistry ◽

10.1139/v08-155 ◽

2008 ◽

Vol 86 (11) ◽

pp. 1070-1076 ◽

Cited By ~ 12

Author(s):

Bhausaheb K Ghotekar ◽

Muddassar A Kazi ◽

Madhukar N Jachak ◽

Raghunath B Toche

Keyword(s):

Good Yield ◽

Substituent Effect ◽

Photophysical Properties ◽

Fluorescence Properties ◽

Absorption And Emission ◽

Effect Of Substituents ◽

Convenient Route

A convenient route was successfully developed for the synthesis of novel heterocycles such as pyrazolo[3,4-b]pyrrolo[2,3-d]pyridines (PPP) from pyrazolo[3,4-b]pyridines in good yield. The PPP derivatives synthesized were further studied for their photophysical properties, and it was observed that absorption and emission λmax changed, owing to the substituent effect at 4 positions. These compounds were obtained from highly reactive starting materials, 5-aminopyrazoles and α-acetyl γ-butyrolactone.Key words: α-acetyl γ-butyrolactone, pyrazolo[3,4-b]pyrrolo[2,3-d] pyridine, absorption, emission, fluorescence.

Download Full-text