Recent advances in two-photon absorbing probes based on a functionalized dipolar naphthalene platform

Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs regulate many physiological processes. They recently attracted attention after extensive studies showed their involvement in metabolic disorders and diseases such as obesity, diabetes, and cancer. Therefore, it is of the highest importance to have reliable imaging tools. In this review, we focus on recent advances in the development of selective fluorescent probes for LDs. Their photophysical properties are described, and their advantages and drawbacks in fluorescence imaging are discussed. At last, we review the reported applications using these probes including two-photon excitation, in vivo and tissue imaging, as well as LDs tracking.

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Recent advances in quinazolinones as an emerging molecular platform for luminescent materials and bioimaging

Organic Chemistry Frontiers ◽

10.1039/d0qo01425g ◽

2021 ◽

Vol 8 (8) ◽

pp. 1867-1889

Author(s):

Zhiming Xing ◽

Wanhui Wu ◽

Yongxiang Miao ◽

Yingqun Tang ◽

Youkang Zhou ◽

...

Keyword(s):

Fluorescent Probes ◽

Biological Imaging ◽

Luminescence Properties ◽

Luminescent Materials ◽

Future Outlook ◽

Recent Advances

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging and luminescent materials. Their future outlook is also included.

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Recent advances in 1,8-naphthalimide-based small-molecule fluorescent probes for organelles imaging and tracking in living cells

Coordination Chemistry Reviews ◽

10.1016/j.ccr.2021.214019 ◽

2021 ◽

Vol 444 ◽

pp. 214019

Author(s):

Haitao Yu ◽

Yan Guo ◽

Wencheng Zhu ◽

Kaden Havener ◽

Xujun Zheng

Keyword(s):

Small Molecule ◽

Fluorescent Probes ◽

Living Cells ◽

Recent Advances

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Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

Chemical Society Reviews ◽

10.1039/d0cs00861c ◽

2021 ◽

Vol 50 (2) ◽

pp. 702-734

Author(s):

Luling Wu ◽

Jihong Liu ◽

Ping Li ◽

Bo Tang ◽

Tony D. James

Keyword(s):

Small Molecule ◽

Biological Systems ◽

Two Photon ◽

Small Molecule Probes ◽

Recent Advances ◽

Design Construction

In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes.

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Two-Photon Fluorescent Probes for Detecting Enzyme Activities in Live Tissues

ACS Applied Bio Materials ◽

10.1021/acsabm.1c00063 ◽

2021 ◽

Author(s):

Vinayak Juvekar ◽

Hyo Won Lee ◽

Hwan Myung Kim

Keyword(s):

Fluorescent Probes ◽

Enzyme Activities ◽

Two Photon

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Recent advances in the targeted fluorescent probes for the detection of metastatic bone cancer

Science China Chemistry ◽

10.1007/s11426-021-9990-x ◽

2021 ◽

Author(s):

Peng Wu ◽

Daniel J. Siegwart ◽

Hu Xiong

Keyword(s):

Fluorescent Probes ◽

Bone Cancer ◽

Recent Advances

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Polarity-active NIR probes with strong two-photon absorption and ultrahigh binding affinity of insulin amyloid fibrils

Chemical Science ◽

10.1039/d0sc03907a ◽

2021 ◽

Author(s):

Li Li ◽

Zheng Lv ◽

Zhongwei Man ◽

Zhenzhen Xu ◽

YuLing Wei ◽

...

Keyword(s):

Neurodegenerative Diseases ◽

Binding Affinity ◽

Fluorescent Probes ◽

Amyloid Fibrils ◽

Photon Absorption ◽

Two Photon Absorption ◽

Two Photon ◽

Medical Diagnostic

Amyloid fibrils are associated with many neurodegenerative diseases. In-situ and in-vivo visualization of amyloid fibrils is important for medical diagnostic and requires fluorescent probes with both excitation and emission wavelengths in...

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