Development of an Integrated High Serum Stability Zwitterionic Polypeptide-Based Nanodrug with Both Rapid Internalization and Endocellular Drug Releasing for Efficient Targeted Chemotherapy

Langmuir ◽  
2021 ◽  
Author(s):  
Ashish Trital ◽  
Weili Xue ◽  
Longgang Wang ◽  
Shengfu Chen
Keyword(s):  
High Serum ◽  
Targeted Chemotherapy ◽  
Serum Stability

scholarly journals High Serum Stability of Collagen Hybridizing Peptides and Their Fluorophore Conjugates

2017 ◽  
Vol 14 (6) ◽  
pp. 1906-1915 ◽  
Author(s):  
Lucas L. Bennink ◽  
Daniel J. Smith ◽  
Catherine A. Foss ◽  
Martin G. Pomper ◽  
Yang Li ◽  
...  
Keyword(s):  
High Serum ◽  
Serum Stability

Arginine modification of lycosin-I to improve inhibitory activity against cancer cells

2017 ◽  
Vol 15 (44) ◽  
pp. 9379-9388 ◽  
Author(s):  
Peng Zhang ◽  
Jing Ma ◽  
Yujie Yan ◽  
Bo Chen ◽  
Bobo Liu ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Solid Tumor ◽  
Inhibitory Activity ◽  
High Serum ◽  
Serum Stability ◽  
Arginine Modification

Herein, arginine modification rendered Lycosin-I with higher anticancer activity, penetrability, and dissemination ability against solid tumor cells due to the optimized physicochemical properties and high serum stability.

Fibronexus-Like Adhesion Sites are Present at the Invasive Zones of Human Epidermoid Carcinomas

1982 ◽  
Vol 40 ◽  
pp. 106-109
Author(s):  
Irwin I. Singer
Keyword(s):  
Cell Cycle ◽  
Serum Concentration ◽  
Substrate Binding ◽  
High Serum ◽  
Adhesion Sites ◽  
Substrate Adhesion ◽  
Focal Contacts ◽  
Adhesion Complex ◽  
Low Serum

Our previous results indicate that two types of fibronectin-cytoskeletal associations may be formed at the fibroblast surface: dorsal matrixbinding fibronexuses generated in high serum (5% FBS) cultures, and ventral substrate-adhering units formed in low serum (0.3% FBS) cultures. The substrate-adhering fibronexus consists of at least vinculin (VN) and actin in its cytoplasmic leg, and fibronectin (FN) as one of its major extracellular components. This substrate-adhesion complex is localized in focal contacts, the sites of closest substratum approach visualized with interference reflection microscopy, which appear to be the major points of cell-tosubstrate adhesion. In fibroblasts, the latter substrate-binding complex is characteristic of cultures that are arrested at the G1 phase of the cell cycle due to the low serum concentration in their medium. These arrested fibroblasts are very well spread, flattened, and immobile.

Benign ovarian fibroma with ascites and high serum levels of CA125: a case report

2007 ◽  
Vol 67 (05) ◽  
Author(s):  
N Shabani ◽  
T Puchner ◽  
H Schütze ◽  
U Jeschke ◽  
I Mylonas ◽  
...  
Keyword(s):  
Case Report ◽  
Serum Levels ◽  
High Serum ◽  
Ovarian Fibroma

High serum miRNA 550a-5p levels are risk factors for incident fractures in older postmenopausal women with type 2 diabetes

2016 ◽  
Author(s):  
Ursula Heilmeier ◽  
Matthias Hackl ◽  
Susanna Skalicky ◽  
Sylvia Weilner ◽  
Fabian Schroeder ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Postmenopausal Women ◽  
High Serum ◽  
Serum Mirna

2315-PUB: High Serum Ferritin Predicts Inferior Diabetes-Related Outcomes after Gastric Bypass but Not Sleeve Gastrectomy Bariatric Surgery

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2315-PUB
Author(s):  
JENNY TONG ◽  
RAFAEL ALVAREZ ◽  
GREGORY B. RUSSELL ◽  
ALEXANDER N. KHOURI ◽  
RANDY J. SEELEY ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Serum Ferritin ◽  
High Serum
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