Oligo(para-phenylenes)s–Oligoarginine Conjugates as Effective Antibacterial Agents with High Plasma Stability and Low Hemolysis

2020 ◽  
Vol 3 (12) ◽  
pp. 8532-8541
Author(s):  
Xingyi Yuan ◽  
Chenhong Wang ◽  
Junyi Chen ◽  
Xiaoyan Shu ◽  
Yao Chai ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
High Plasma ◽  
Plasma Stability

scholarly journals Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif

2018 ◽  
Vol 9 ◽  
Author(s):  
Santosh Kumar Adla ◽  
Barbora Slavikova ◽  
Hana Chodounska ◽  
Vojtech Vyklicky ◽  
Marek Ladislav ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
High Plasma ◽  
Structural Motif ◽  
Plasma Stability ◽  
Strong Inhibitory Effect ◽  
Low Cytotoxicity

scholarly journals Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability

2016 ◽  
Vol 7 (9) ◽  
pp. 841-846 ◽  
Author(s):  
Erika J. Olson ◽  
Bernhard C. Lechtenberg ◽  
Chunxia Zhao ◽  
Elena Rubio de la Torre ◽  
Ilaria Lamberto ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
High Plasma ◽  
Plasma Stability ◽  
Peptide Antagonist

0.15 μm T-gate E-beam lithography using crosslinked P(MMA/MMA) developed in ortho-xylene resulting in high contrast and high plasma stability for dry etched recess gate pseudomorphic MODFETs for MMIC production

1994 ◽  
Vol 23 (1-4) ◽  
pp. 437-440 ◽  
Author(s):  
A. Hülsmann ◽  
E. Mühlfriedel ◽  
B. Raynor ◽  
K. Glorer ◽  
W. Bronner ◽  
...  
Keyword(s):  
High Plasma ◽  
Plasma Stability ◽  
High Contrast

scholarly journals Plasma Stability in a Tokamak with Reactor Technologies Taking into Account the Pressure Pedestal

2021 ◽  
Vol 47 (11) ◽  
pp. 1119-1127
Author(s):  
S. Yu. Medvedev ◽  
A. A. Martynov ◽  
S. V. Konovalov ◽  
V. M. Leonov ◽  
V. E. Lukash ◽  
...  
Keyword(s):  
Current Density ◽  
Stability Limit ◽  
High Plasma ◽  
Quasi Equilibrium ◽  
Plasma Stability ◽  
Density Profiles ◽  
Edge Localized Modes ◽  
Operating Limits ◽  
Plasma Torus ◽  
The Stability

Abstract Studying stationary regimes with high plasma confinement in a tokamak with reactor technologies (TRT) [1] involves calculating the plasma stability taking into account the influence of the current density profiles and pressure gradient in the pedestal near the boundary. At the same time, the operating limits should be determined by the parameters of the pedestal, which, in particular, are set by the stability limit of the peeling–ballooning modes that trigger the peripheral disruption of edge localized modes (ELM). Using simulation of the quasi-equilibrium evolution of the plasma by the ASTRA and DINA codes, as well as a simulator of magnetohydrodynamic (MHD) modes localized at the boundary of the plasma torus based on the KINX code, stability calculations are performed for different plasma scenarios in the TRT with varying plasma density and temperature profiles, as well as the corresponding bootstrap current density in the pedestal region. At the same time, experimental scalings for the width of the pedestal are used. The obtained pressure values are below the limits for an ITER-like plasma due to the lower triangularity and higher aspect ratio of TRT plasma. For the same reason, the reversal of magnetic field shear in the pedestal occurs at a lower current density, which causes the instability of modes with low toroidal wave numbers and reduces the effect of diamagnetic stabilization.

Author response for "Daratumumab for Relapsed or Refractory AL Amyloidosis with high Plasma Cell Burden"

2019 ◽  
Author(s):  
Rahel Schwotzer ◽  
Markus Gabriel Manz ◽  
Stefanie Pederiva ◽  
Christine Waibel ◽  
Clemens Caspar ◽  
...  
Keyword(s):  
Plasma Cell ◽  
High Plasma ◽  
Author Response ◽  
Al Amyloidosis

Dermatitis in pets: Study of Brazilian savannah plants as potential antibacterial agents

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
AC Valle ◽  
L Rabelo ◽  
AL Magalhães ◽  
M Neves ◽  
I Maciel ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Brazilian Savannah

Relation between Plasminogen Activator Inhibitor-1 and Hepatic Enzyme Concentrations in Hyperlipidemic Patients

1994 ◽  
Vol 72 (03) ◽  
pp. 434-437 ◽  
Author(s):  
E Bruckert ◽  
A Ankri ◽  
P Glral ◽  
G Turpin
Keyword(s):  
Blood Pressure ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Tolerance Test ◽  
High Plasma ◽  
Oral Glucose ◽  
Plasminogen Activator Inhibitor 1 ◽  
Glutamyl Transferase ◽  
Activator Inhibitor ◽  
Pai 1

SummaryPlasminogen activator inhibitor type-1 (PAI-1) is a key determinant of the fibrinolytic capacity. Its activity correlates with most of the characteristic features of insulin resistance syndrome, i. e. obesity, high blood pressure and hyperlipidemia.We measured plasma PAI-1 antigen levels in 131 asymptomatic men (aged 44.2 ± 11 years) who had been referred for hyperlipidemia. Those taking medication and those with a secondary hyperlipidemia were excluded.We confirmed the correlation between PAI-1 levels and the following variables: body mass index, blood pressure, triglyceride concentration, and blood glucose and insulin levels before and after an oral glucose tolerance test. We also found a significant and independent correlation between PAI-1 and the concentration of the hepatic enzymes glutamyl transferase, alanine aminotransferase and aspartate aminotransferase.Mild liver abnormalities (presumably steatosis) may thus be one of the factors accounting for high plasma PAI-1 levels in hyperlipidemic patients.

Respective Roles of Antithrombin III and Alpha 2 Macroglobulin in Thrombin Inactivation

1981 ◽  
Vol 45 (01) ◽  
pp. 051-054 ◽  
Author(s):  
A M Fischer ◽  
J Tapon-Bretaudiere ◽  
A Bros ◽  
F Josso
Keyword(s):  
Antithrombin Iii ◽  
Practical Interest ◽  
High Plasma ◽  
At Iii ◽  
Human Material ◽  
Cofactor Activity

SummaryIn order to investigate the mechanism of thrombin inactivation in the presence of both antithrombin III (AT III) and α 2-macroglobulin (α 2 M), thrombin and the inhibitors have been purified from human material and thrombin inactivation studied using purified reagents either alone or added to defibrinated plasma. Comparison of clotting and amidolytic activities of residual thrombin allowed to measure the amount of thrombin bound to α 2 M. In a purified reagent system as well as in plasma, part of exogenous thrombin is bound to α 2 M. The amount of bound thrombin is related to α 2 M concentration. Conversely, previous plasma α 2 M depletion by immunoabsorption increases the consumption of heparin-cofactor activity by exogenous thrombin. Thus AT III and α 2 M compete for thrombin inactivation. This finding could be of practical interest in clinical situations associating high plasma α 2 M levels and a decrease of AT III concentration.

Intoxication with Phenprocoumon (Marcoumar) Pharmacokinetics and Side Effects

1969 ◽  
Vol 21 (02) ◽  
pp. 320-324 ◽  
Author(s):  
K Seiler ◽  
F Duckert
Keyword(s):  
Plasma Concentration ◽  
Side Effects ◽  
Half Life ◽  
Plasma Proteins ◽  
Repeated Administration ◽  
High Plasma ◽  
Vitamin K1 ◽  
Clotting Factors ◽  
Therapeutic Concentration ◽  
High Plasma Concentration

SummaryA case of severe Marcoumar intoxication is described. Eleven hours after the intake a plasma concentration of 15.75 µg/ml was found which corresponds approximately to the 5-fold therapeutic concentration. Repeated administration of vitamin K1 made it possible to avoid extreme lowering of the activity of the clotting factors II, VII and X and to prevent bleeding. Side effects were not observed. The biologic half-life of Phenprocoumon has been found to be shortened at high plasma concentration (3.7 instead of 5.9 days). It is probable that in extreme concentration the drug is less strongly bound to the plasma proteins.

Low serum thyrotropin is associated with high plasma fibrinogen levels. The Study of Health in Pomerania

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
M Dörr ◽  
U John ◽  
H Wallaschofski ◽  
SB Felix ◽  
H Völzke
Keyword(s):  
High Plasma ◽  
Plasma Fibrinogen ◽  
Low Serum
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