Oligo(para-phenylenes)s–Oligoarginine Conjugates as Effective Antibacterial Agents with High Plasma Stability and Low Hemolysis

2020 ◽  
Vol 3 (12) ◽  
pp. 8532-8541
Author(s):  
Xingyi Yuan ◽  
Chenhong Wang ◽  
Junyi Chen ◽  
Xiaoyan Shu ◽  
Yao Chai ◽  
...  
2016 ◽  
Vol 7 (9) ◽  
pp. 841-846 ◽  
Author(s):  
Erika J. Olson ◽  
Bernhard C. Lechtenberg ◽  
Chunxia Zhao ◽  
Elena Rubio de la Torre ◽  
Ilaria Lamberto ◽  
...  

2021 ◽  
Vol 47 (11) ◽  
pp. 1119-1127
Author(s):  
S. Yu. Medvedev ◽  
A. A. Martynov ◽  
S. V. Konovalov ◽  
V. M. Leonov ◽  
V. E. Lukash ◽  
...  

Abstract Studying stationary regimes with high plasma confinement in a tokamak with reactor technologies (TRT) [1] involves calculating the plasma stability taking into account the influence of the current density profiles and pressure gradient in the pedestal near the boundary. At the same time, the operating limits should be determined by the parameters of the pedestal, which, in particular, are set by the stability limit of the peeling–ballooning modes that trigger the peripheral disruption of edge localized modes (ELM). Using simulation of the quasi-equilibrium evolution of the plasma by the ASTRA and DINA codes, as well as a simulator of magnetohydrodynamic (MHD) modes localized at the boundary of the plasma torus based on the KINX code, stability calculations are performed for different plasma scenarios in the TRT with varying plasma density and temperature profiles, as well as the corresponding bootstrap current density in the pedestal region. At the same time, experimental scalings for the width of the pedestal are used. The obtained pressure values are below the limits for an ITER-like plasma due to the lower triangularity and higher aspect ratio of TRT plasma. For the same reason, the reversal of magnetic field shear in the pedestal occurs at a lower current density, which causes the instability of modes with low toroidal wave numbers and reduces the effect of diamagnetic stabilization.


2019 ◽  
Author(s):  
Rahel Schwotzer ◽  
Markus Gabriel Manz ◽  
Stefanie Pederiva ◽  
Christine Waibel ◽  
Clemens Caspar ◽  
...  

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
AC Valle ◽  
L Rabelo ◽  
AL Magalhães ◽  
M Neves ◽  
I Maciel ◽  
...  

1994 ◽  
Vol 72 (03) ◽  
pp. 434-437 ◽  
Author(s):  
E Bruckert ◽  
A Ankri ◽  
P Glral ◽  
G Turpin

SummaryPlasminogen activator inhibitor type-1 (PAI-1) is a key determinant of the fibrinolytic capacity. Its activity correlates with most of the characteristic features of insulin resistance syndrome, i. e. obesity, high blood pressure and hyperlipidemia.We measured plasma PAI-1 antigen levels in 131 asymptomatic men (aged 44.2 ± 11 years) who had been referred for hyperlipidemia. Those taking medication and those with a secondary hyperlipidemia were excluded.We confirmed the correlation between PAI-1 levels and the following variables: body mass index, blood pressure, triglyceride concentration, and blood glucose and insulin levels before and after an oral glucose tolerance test. We also found a significant and independent correlation between PAI-1 and the concentration of the hepatic enzymes glutamyl transferase, alanine aminotransferase and aspartate aminotransferase.Mild liver abnormalities (presumably steatosis) may thus be one of the factors accounting for high plasma PAI-1 levels in hyperlipidemic patients.


1981 ◽  
Vol 45 (01) ◽  
pp. 051-054 ◽  
Author(s):  
A M Fischer ◽  
J Tapon-Bretaudiere ◽  
A Bros ◽  
F Josso

SummaryIn order to investigate the mechanism of thrombin inactivation in the presence of both antithrombin III (AT III) and α 2-macroglobulin (α 2 M), thrombin and the inhibitors have been purified from human material and thrombin inactivation studied using purified reagents either alone or added to defibrinated plasma. Comparison of clotting and amidolytic activities of residual thrombin allowed to measure the amount of thrombin bound to α 2 M. In a purified reagent system as well as in plasma, part of exogenous thrombin is bound to α 2 M. The amount of bound thrombin is related to α 2 M concentration. Conversely, previous plasma α 2 M depletion by immunoabsorption increases the consumption of heparin-cofactor activity by exogenous thrombin. Thus AT III and α 2 M compete for thrombin inactivation. This finding could be of practical interest in clinical situations associating high plasma α 2 M levels and a decrease of AT III concentration.


1969 ◽  
Vol 21 (02) ◽  
pp. 320-324 ◽  
Author(s):  
K Seiler ◽  
F Duckert

SummaryA case of severe Marcoumar intoxication is described. Eleven hours after the intake a plasma concentration of 15.75 µg/ml was found which corresponds approximately to the 5-fold therapeutic concentration. Repeated administration of vitamin K1 made it possible to avoid extreme lowering of the activity of the clotting factors II, VII and X and to prevent bleeding. Side effects were not observed. The biologic half-life of Phenprocoumon has been found to be shortened at high plasma concentration (3.7 instead of 5.9 days). It is probable that in extreme concentration the drug is less strongly bound to the plasma proteins.


2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
M Dörr ◽  
U John ◽  
H Wallaschofski ◽  
SB Felix ◽  
H Völzke

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