Folic Acid and Poly(ethylene glycol) Decorated Paclitaxel Nanocrystals Exhibit Enhanced Stability and Breast Cancer-Targeting Capability

2021 ◽  
Author(s):  
Jihui Zhao ◽  
Jianliang Du ◽  
Jun Wang ◽  
Na An ◽  
Kuan Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Cancer Targeting ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Enhanced Stability

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graphene Quantum Dots ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

Selective chemotherapy and imaging of colorectal and breast cancer cells by a modified MUC-1 aptamer conjugated to a poly(ethylene glycol)-dimethacrylate coated Fe3O4–AuNCs nanocomposite

2019 ◽  
Vol 43 (1) ◽  
pp. 238-248 ◽  
Author(s):  
Roya Binaymotlagh ◽  
Farid Hajareh Haghighi ◽  
Fatemeh Aboutalebi ◽  
Seyede Zohreh Mirahmadi-Zare ◽  
Hassan Hadadzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Ethylene Glycol ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Molecular Medicine ◽  
Glycol Dimethacrylate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Selective Chemotherapy

The combination of diagnosis and targeted therapy within a single nanoplatform is one of the remarkable advances in molecular medicine.

scholarly journals Enhanced Stability and Knockdown Efficiency of Poly(ethylene glycol)-b-polyphosphoramidate/siRNA Micellar Nanoparticles by Co-condensation with Sodium Triphosphate

2011 ◽  
Vol 28 (7) ◽  
pp. 1723-1732 ◽  
Author(s):  
Masataka Nakanishi ◽  
Rajesh Patil ◽  
Yong Ren ◽  
Rishab Shyam ◽  
Philip Wong ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Enhanced Stability ◽  
Micellar Nanoparticles

Methoxy Poly(ethylene glycol)-Poly(lactide) Nanoparticles Encapsulating Quercetin Act as an Effective Anticancer Agent by Inducing Apoptosis in Breast Cancer

2014 ◽  
Vol 32 (2) ◽  
pp. 723-735 ◽  
Author(s):  
Garima Sharma ◽  
Jongbong Park ◽  
Ashish Ranjan Sharma ◽  
Jun-Sub Jung ◽  
Haesung Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Anticancer Agent ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(ethylene glycol)–paclitaxel–alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases

Biomaterials ◽  
2013 ◽  
Vol 34 (15) ◽  
pp. 3795-3806 ◽  
Author(s):  
Keren Miller ◽  
Chiara Clementi ◽  
Dina Polyak ◽  
Anat Eldar-Boock ◽  
Liat Benayoun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Bone Metastases ◽  
Targeted Treatment ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

Specific Antitumor Targetable β-Cyclodextrin−Poly(ethylene Glycol)−Folic Acid Drug Delivery Bioconjugate

2004 ◽  
Vol 15 (5) ◽  
pp. 997-1004 ◽  
Author(s):  
Stefano Salmaso ◽  
Alessandra Semenzato ◽  
Paolo Caliceti ◽  
Johan Hoebeke ◽  
Fabio Sonvico ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

In vivo study of poly (ethylene glycol)-poly (caprolactone)-modified folic acid nanocarriers as a pH responsive system for tumor-targeted co-delivery of tamoxifen and quercetin

2019 ◽  
Vol 54 ◽  
pp. 101283 ◽  
Author(s):  
Mostafa Zamani ◽  
Mozhgan Aghajanzadeh ◽  
Kobra Rostamizadeh ◽  
Hamidreza Kheiri Manjili ◽  
Mohammadjavad Fridoni ◽  
...  
Keyword(s):  
Folic Acid ◽  
Ethylene Glycol ◽  
In Vivo Study ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Poly Caprolactone
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