Specific Antitumor Targetable β-Cyclodextrin−Poly(ethylene Glycol)−Folic Acid Drug Delivery Bioconjugate

2004 ◽  
Vol 15 (5) ◽  
pp. 997-1004 ◽  
Author(s):  
Stefano Salmaso ◽  
Alessandra Semenzato ◽  
Paolo Caliceti ◽  
Johan Hoebeke ◽  
Fabio Sonvico ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graphene Quantum Dots ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

Recent development of poly(ethylene glycol)-cholesterol conjugates as drug delivery systems

2014 ◽  
Vol 469 (1) ◽  
pp. 168-178 ◽  
Author(s):  
Zhi-Yao He ◽  
Bing-Yang Chu ◽  
Xia-Wei Wei ◽  
Jiao Li ◽  
Carl K. Edwards ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Controlled Release of Proteins from Their Poly(Ethylene Glycol) Conjugates:  Drug Delivery Systems Employing 1,6-Elimination

2003 ◽  
Vol 14 (2) ◽  
pp. 395-403 ◽  
Author(s):  
Richard B. Greenwald ◽  
Karen Yang ◽  
Hong Zhao ◽  
Charles D. Conover ◽  
Stanford Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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