Methoxy Poly(ethylene glycol)-Poly(lactide) Nanoparticles Encapsulating Quercetin Act as an Effective Anticancer Agent by Inducing Apoptosis in Breast Cancer

2014 ◽  
Vol 32 (2) ◽  
pp. 723-735 ◽  
Author(s):  
Garima Sharma ◽  
Jongbong Park ◽  
Ashish Ranjan Sharma ◽  
Jun-Sub Jung ◽  
Haesung Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Anticancer Agent ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Selective chemotherapy and imaging of colorectal and breast cancer cells by a modified MUC-1 aptamer conjugated to a poly(ethylene glycol)-dimethacrylate coated Fe3O4–AuNCs nanocomposite

2019 ◽  
Vol 43 (1) ◽  
pp. 238-248 ◽  
Author(s):  
Roya Binaymotlagh ◽  
Farid Hajareh Haghighi ◽  
Fatemeh Aboutalebi ◽  
Seyede Zohreh Mirahmadi-Zare ◽  
Hassan Hadadzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Ethylene Glycol ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Molecular Medicine ◽  
Glycol Dimethacrylate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Selective Chemotherapy

The combination of diagnosis and targeted therapy within a single nanoplatform is one of the remarkable advances in molecular medicine.

Poly(ethylene glycol)–paclitaxel–alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases

Biomaterials ◽  
2013 ◽  
Vol 34 (15) ◽  
pp. 3795-3806 ◽  
Author(s):  
Keren Miller ◽  
Chiara Clementi ◽  
Dina Polyak ◽  
Anat Eldar-Boock ◽  
Liat Benayoun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ethylene Glycol ◽  
Bone Metastases ◽  
Targeted Treatment ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

Co-delivery of paclitaxel and gemcitabine by methoxy poly(ethylene glycol)–poly(lactide-coglycolide)-polypeptide nanoparticles for effective breast cancer therapy

2018 ◽  
Vol 29 (7) ◽  
pp. 637-645 ◽  
Author(s):  
Shiliang Dong ◽  
Yuexin Guo ◽  
Yishuang Duan ◽  
Zhaoming Li ◽  
Chan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Breast Cancer Therapy ◽  
Poly Ethylene

Enhancing the performance of PEG-b-PCL-based nanocarriers for curcumin through its conjugation with lipophilic biomolecules

2020 ◽  
Vol 35 (4-5) ◽  
pp. 399-413 ◽  
Author(s):  
Angie V Angarita ◽  
Adriana Umaña-Perez ◽  
Leon D Perez
Keyword(s):  
Breast Cancer ◽  
Oleic Acid ◽  
Ethylene Glycol ◽  
Anticancer Activity ◽  
Polymeric Materials ◽  
Critical Aggregation Concentration ◽  
Proton Nuclear Magnetic Resonance ◽  
Polymer Micelles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Curcumin is a natural substance extracted from Curcuma longa Linn with beneficial pharmaceutical properties such as anticancer activity against several cellular lines. However, it presents poor bioavailability due to its low solubility in aqueous media and chemical instability. In this research, curcumin was encapsulated in polymer micelles obtained by the self-assembly of a biodegradable poly (ethylene glycol)-block-poly(ɛ-caprolactone) copolymer conjugated with cholesterol or oleic acid. A hydroxyl-terminated poly (ethylene glycol)-block-poly(ɛ-caprolactone) was reacted with cholesteryl chloroformate or oleyl chloride to obtain conjugated copolymers. The resulting polymeric materials were characterised through proton nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry, and their critical aggregation concentration was measured through fluorescence spectroscopy. Poly (ethylene glycol)-block-poly(ɛ-caprolactone) conjugated with cholesterol and oleic acid posed an improved capacity of encapsulating curcumin, resulting in the loading capacities of 8.8% and 15.2%, respectively. Cell viability studies confirmed that curcumin loaded in polymer micelles maintained its anticancer activity against MCF-7 human breast cancer cells but presented low cytotoxicity against mouse fibroblasts. Hence, these formulations have good potential for applications in drug delivery systems for breast cancer treatment.

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