Near-Infrared Light-Responsive Poly(N-isopropylacrylamide)/Graphene Oxide Nanocomposite Hydrogels with Ultrahigh Tensibility

2015 ◽  
Vol 7 (49) ◽  
pp. 27289-27298 ◽  
Author(s):  
Kun Shi ◽  
Zhuang Liu ◽  
Yun-Yan Wei ◽  
Wei Wang ◽  
Xiao-Jie Ju ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nanocomposite Hydrogels

Sulfobetaine methacrylate-albumin-coated graphene oxide incorporating IR780 for enhanced breast cancer phototherapy

Nanomedicine ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. 453-464
Author(s):  
Bruna L Melo ◽  
Rita Lima-Sousa ◽  
Cátia G Alves ◽  
Paula Ferreira ◽  
André F Moreira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Bovine Serum Albumin ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Colloidal Stability ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Biologically Relevant

Aim: Enhance the colloidal stability and photothermal capacity of graphene oxide (GO) by functionalizing it with sulfobetaine methacrylate (SBMA)-grafted bovine serum albumin (BSA; i.e., SBMA- g-BSA) and by loading IR780, respectively. Materials & methods: SBMA- g-BSA coating and IR780 loading into GO was achieved through a simple sonication process. Results: SBMA- g-BSA-functionalized GO (SBMA-BSA/GO) presented an adequate size distribution and cytocompatibility. When in contact with biologically relevant media, the size of the SBMA-BSA/GO only increased by 8%. By loading IR780 into SBMA-BSA/GO, its photothermal capacity increased by twofold. The combination of near infrared light with SBMA-BSA/GO did not induce photocytotoxicity on breast cancer cells. In contrast, the interaction of IR780-loaded SBMA-BSA/GO with near infrared light caused the ablation of cancer cells. Conclusion: IR780-loaded SBMA-BSA/GO displayed an improved colloidal stability and phototherapeutic capacity.

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