scholarly journals Functionalization of Reduced Graphene Oxide via Thiol–Maleimide “Click” Chemistry: Facile Fabrication of Targeted Drug Delivery Vehicles

2017 ◽  
Vol 9 (39) ◽  
pp. 34194-34203 ◽  
Author(s):  
Yavuz Oz ◽  
Alexandre Barras ◽  
Rana Sanyal ◽  
Rabah Boukherroub ◽  
Sabine Szunerits ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Click Chemistry ◽  
Reduced Graphene Oxide ◽  
Targeted Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Reduced Graphene ◽  
Facile Fabrication ◽  
Delivery Vehicles ◽  
Targeted Drug

scholarly journals Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

2015 ◽  
Vol 6 (8) ◽  
pp. 1286-1299 ◽  
Author(s):  
D. D. Lane ◽  
D. Y. Chiu ◽  
F. Y. Su ◽  
S. Srinivasan ◽  
H. B. Kern ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Raft Polymerization ◽  
Chemotherapeutic Agents ◽  
Polymer Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Targeted Drug

Second generation polymeric brushes with molecular weights in excess of 106 Da were synthesize via RAFT polymerization for use as antibody targeted drug delivery vehicles.

scholarly journals Editorial: Stem Cells as Targeted Drug Delivery Vehicles

2020 ◽  
Vol 11 ◽  
Author(s):  
Gina D. Kusuma ◽  
Jessica E. Frith ◽  
Christopher G. Sobey ◽  
Rebecca Lim
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug

scholarly journals Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Xiaojiao Yu ◽  
Ian Trase ◽  
Muqing Ren ◽  
Kayla Duval ◽  
Xing Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Active Targeting ◽  
Physical Interaction ◽  
Computational Simulations ◽  
Delivery Methods ◽  
Passive Targeting ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug

Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.

Biomolecular-conjugated nanoparticles for biomedical applications

2016 ◽  
Vol 1 (01) ◽  
Author(s):  
Prachi Goyal ◽  
Kamani Parmar ◽  
Sonika Gupta ◽  
Mukesh Sharma ◽  
M. P. Dobhal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Targeted Drug Delivery ◽  
Molecular Motors ◽  
Biomedical Applications ◽  
Biological Functions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
Cellular Compartments

Bimolecular-conjugated nanoparticles (NP) demonstrate unique properties with wide-ranging applications in the diagnosis of infectious diseases as well as application in gene therapy and drug delivery therapies. The unique properties and utility of NP arise from a variety of attributes, including the similar size of nanoparticles and biomolecules. Biological functions depend primarily on units that have nanoscale dimensions, such as viruses, ribosomes, molecular motors and components of the extra cellular matrix. In addition, engineered devices at the nanoscale are small enough to interact directly with sub-cellular compartments and to probe intracellular events. This review focuses on the methods of nanoparticle interaction with different biomolecules such as antibodies, DNA, lipids, and proteins. More specifically, there is discussion about bioconjugation linkage and a summary of potential biomedical applications of bio-conjugated nanoparticles as targeted drug delivery vehicles.

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