scholarly journals Electrospun Polyhydroxybutyrate/Poly(ε-caprolactone)/Sol–Gel-Derived Silica Hybrid Scaffolds with Drug Releasing Function for Bone Tissue Engineering Applications

2018 ◽  
Vol 10 (17) ◽  
pp. 14540-14548 ◽  
Author(s):  
Yaping Ding ◽  
Wei Li ◽  
Alexandra Correia ◽  
Yuyun Yang ◽  
Kai Zheng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sol Gel ◽  
Engineering Applications ◽  
Hybrid Scaffolds ◽  
Silica Hybrid

Synthesis, neutralization and blocking procedures of organic/inorganic hybrid scaffolds for bone tissue engineering applications

2008 ◽  
Vol 20 (2) ◽  
pp. 529-535 ◽  
Author(s):  
Hermes S. Costa ◽  
Edel F. B. Stancioli ◽  
Marivalda M. Pereira ◽  
Rodrigo L. Oréfice ◽  
Herman S. Mansur
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Inorganic Hybrid ◽  
Hybrid Scaffolds

Bioactive borophosphosilicate-polycaprolactone hybrid biomaterials via a non-aqueous sol gel process

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 92824-92832 ◽  
Author(s):  
Dibakar Mondal ◽  
Amin S. Rizkalla ◽  
Kibret Mequanint
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sol Gel ◽  
Class Ii ◽  
Engineering Applications ◽  
Sol Gel Process ◽  
Hybrid Biomaterials ◽  
Borophosphosilicate Glass

A non-aqueous sol–gel process was utilized to prepare novel class II hybrid biomaterials based on functionalized polycaprolactone diol and borophosphosilicate glass for bone tissue engineering applications.

scholarly journals Fabrication techniques involved in developing the composite scaffolds PCL/HA nanoparticles for bone tissue engineering applications

2021 ◽  
Vol 32 (8) ◽  
Author(s):  
Sivasankar Murugan ◽  
Sreenivasa Rao Parcha
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Freeze Drying ◽  
Composite Scaffold ◽  
Sol Gel ◽  
Bone Tissue Regeneration ◽  
Thermally Induced Phase Separation ◽  
Engineering Applications ◽  
Thermally Induced

AbstractA fine-tuned combination of scaffolds, biomolecules, and mesenchymal stem cells (MSCs) is used in tissue engineering to restore the function of injured bone tissue and overcome the complications associated with its regeneration. For two decades, biomaterials have attracted much interest in mimicking the native extracellular matrix of bone tissue. To this aim, several approaches based on biomaterials combined with MSCs have been amply investigated. Recently, hydroxyapatite (HA) nanoparticles have been incorporated with polycaprolactone (PCL) matrix as a suitable substitute for bone tissue engineering applications. This review article aims at providing a brief overview on PCL/HA composite scaffold fabrication techniques such as sol–gel, rapid prototyping, electro-spinning, particulate leaching, thermally induced phase separation, and freeze-drying, as suitable approaches for tailoring morphological, mechanical, and biodegradability properties of the scaffolds for bone tissues. Among these methods, the 3D plotting method shows improvements in pore architecture (pore size of ≥600 µm and porosity of 92%), mechanical properties (higher than 18.38 MPa), biodegradability, and good bioactivity in bone tissue regeneration.

scholarly journals A Proposed Fabrication Method of Novel PCL-GEL-HAp Nanocomposite Scaffolds for Bone Tissue Engineering Applications

2010 ◽  
Vol 19 (4) ◽  
pp. 096369351001900 ◽  
Author(s):  
A. Hamlekhan ◽  
M. Mozafari ◽  
N. Nezafati ◽  
M. Azami ◽  
H. Hadipour
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Test ◽  
Fibroblast Cell ◽  
Mouse Fibroblast ◽  
Fabrication Method ◽  
Engineering Applications ◽  
Poly Caprolactone

In this study, poly(∊-caprolactone) (PCL), gelatin (GEL) and nanocrystalline hydroxyapatite (HAp) was applied to fabricate novel PCL-GEL-HAp nanaocomposite scaffolds through a new fabrication method. With the aim of finding the best fabrication method, after testing different methods and solvents, the best method and solvents were found, and the nanocomposites were prepared through layer solvent casting combined with freeze-drying. Acetone and distillated water were used as the PCL and GEL solvents, respectively. The mechanical test showed that the increasing of the PCL weight through the scaffolds caused the improvement of the final nanocomposite mechanical behavior due to the increasing of the ultimate stress, stiffness and elastic modulus (8 MPa for 0% wt PCL to 23.5 MPa for 50% wt PCL). The biomineralization investigation of the scaffolds revealed the formation of bone-like apatite layers after immersion in simulated body fluid (SBF). In addition, the in vitro cytotoxity of the scaffolds using L929 mouse fibroblast cell line (ATCC) indicated no sign of toxicity. These results indicated that the fabricated scaffold possesses the prerequisites for bone tissue engineering applications.

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