G-Quadruplex/Porphyrin Composite Photosensitizer: A Facile Way to Promote Absorption Redshift and Photodynamic Therapy Efficacy

2019 ◽  
Vol 11 (14) ◽  
pp. 13158-13167 ◽  
Author(s):  
Meng Cheng ◽  
Yun-Xi Cui ◽  
Jing Wang ◽  
Jing Zhang ◽  
Li-Na Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Therapy Efficacy ◽  
G Quadruplex ◽  
Absorption Redshift

Current phthalocyanines delivery systems in photodynamic therapy: an updated review

2021 ◽  
Vol 28 ◽  
Author(s):  
Mariana Miretti ◽  
Cesar German Prucca ◽  
Tomas Cristian Tempesti ◽  
Maria Teresa Baumgartner
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Aqueous Media ◽  
Delivery Systems ◽  
Current Status ◽  
Oxygen Species ◽  
Cancer Treatments ◽  
Therapy Efficacy ◽  
Cellular Components

: Photodynamic therapy has emerged as an effective therapeutic alternative to treat oncological, cardiovascular, dermatological, infectious, and ophthalmic diseases. Photodynamic therapy combines the action of a photosensitizer with light in the presence of oxygen to generate reactive oxygen species capable of reacting with cellular components resulting in injury and, consequently, inducing cellular death. Phthalocyanines are considered good photosensitizers, although most of them are lipophilic, difficulting their administration for clinical use. A strategy to overcome the lack of solubility of phthalocyanines in aqueous media is to incorporate them into different delivery systems. The present review aimed to summarize the current status of the main drug delivery systems used for Zn and Al phthalocyanines and their effect in photodynamic therapy, reported in the last five years. Liposomes, polymeric micelles, polymeric nanoparticles, and gold-nanoparticles constituted some of the most used carriers and were discussed in this review. The latest studies reported strongly suggests that the application of nanotechnologies as delivery systems allow an increase in photodynamic therapy efficacy and reduce side-effects associated with the phthalocyanine administration, which represents a promise for cancer treatments.

scholarly journals Enhancing the photodynamic therapy efficacy of black phosphorus nanosheets by covalently grafting fullerene C60

2020 ◽  
Vol 11 (42) ◽  
pp. 11435-11442 ◽  
Author(s):  
Yajuan Liu ◽  
Daoming Zhu ◽  
Xianjun Zhu ◽  
Gaoke Cai ◽  
Jianhua Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Black Phosphorus ◽  
Fullerene C60 ◽  
Inhibition Rate ◽  
Tumor Inhibition ◽  
Therapy Efficacy ◽  
Tumor Inhibition Rate

Covalently grafting C60 molecules onto black phosphorus (BP) nanosheets improves their tumor inhibition rate from 36.6% to 88.2%.

Biomodulation of metabolic and signaling pathways to enhance photodynamic therapy efficacy for pancreatic adenocarcinoma

2017 ◽  
Vol 17 ◽  
pp. A66
Author(s):  
S. Anbil ◽  
Y. Baglo ◽  
M. Broekgaarden ◽  
I. Rizvi ◽  
E. Maytin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Signaling Pathways ◽  
Pancreatic Adenocarcinoma ◽  
Therapy Efficacy

scholarly journals Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ

2017 ◽  
Vol 20 ◽  
pp. 227-233 ◽  
Author(s):  
Ana Luiza Ribeiro de Souza ◽  
Ethan LaRochelle ◽  
Kayla Marra ◽  
Jason Gunn ◽  
Scott C. Davis ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Dose Rate ◽  
Low Dose ◽  
Biological Damage ◽  
Therapy Efficacy ◽  
Low Dose Rate

Distribution, Trafficking, and in Vitro Photodynamic Therapy Efficacy of Cholesterol Silicon(IV) Phthalocyanine and Its Nanoparticles in Breast Cancer Cells

2019 ◽  
Vol 2 (12) ◽  
pp. 5976-5984 ◽  
Author(s):  
Xiuqin Chen ◽  
Qiumei Guo ◽  
Shiqing Dong ◽  
Jianling Chen ◽  
Shusen Xie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Therapy Efficacy

Evaluation of cancer imaging potential and photodynamic therapy efficacy of copper (II) benzyloxypheophorbide-a

2014 ◽  
Vol 23 (1) ◽  
pp. 89-95 ◽  
Author(s):  
Kasim Ocakoglu ◽  
Özge Er ◽  
Fatma Yurt Lambrecht ◽  
Sunde Yılmaz Süslüer ◽  
Cağla Kayabasi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Imaging ◽  
Therapy Efficacy

Silencing of ALA dehydratase affects ALA-photodynamic therapy efficacy in K562 erythroleukemic cells

2009 ◽  
Vol 8 (10) ◽  
pp. 1461 ◽  
Author(s):  
Tamar Feuerstein ◽  
Avital Schauder ◽  
Zvi Malik
Keyword(s):  
Photodynamic Therapy ◽  
Therapy Efficacy ◽  
Ala Dehydratase ◽  
Erythroleukemic Cells

Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11180-11186 ◽  
Author(s):  
Vusala Ibrahimova ◽  
Sergey A. Denisov ◽  
Kevin Vanvarenberg ◽  
Peter Verwilst ◽  
Véronique Préat ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Therapy Efficacy

The localization of the photosensitizer conjugation site in amphiphilic block copolymers has a great impact on photodynamic therapy efficiency.

Enhancing Photodynamic Therapy Efficacy by Using Fluorinated Nanoplatform

2016 ◽  
Vol 5 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Yurong Que ◽  
Yajing Liu ◽  
Wei Tan ◽  
Chun Feng ◽  
Ping Shi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Therapy Efficacy
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