Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting

2019 ◽  
Vol 11 (50) ◽  
pp. 46419-46426 ◽  
Author(s):  
Honglei Jian ◽  
Meiyue Wang ◽  
Qianqian Dong ◽  
Jieling Li ◽  
Anhe Wang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Bioprinting ◽  
Self Assembled ◽  
Tunable Mechanical Properties

scholarly journals 3D Printing of High Viscosity Reinforced Silicone Elastomers

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2239
Author(s):  
Nicholas Rodriguez ◽  
Samantha Ruelas ◽  
Jean-Baptiste Forien ◽  
Nikola Dudukovic ◽  
Josh DeOtte ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Performance ◽  
New Technologies ◽  
Three Dimensional ◽  
High Viscosity ◽  
Layer By Layer ◽  
Silicone Elastomers ◽  
Uv Curable ◽  
Octet Truss ◽  
Tunable Mechanical Properties

Recent advances in additive manufacturing, specifically direct ink writing (DIW) and ink-jetting, have enabled the production of elastomeric silicone parts with deterministic control over the structure, shape, and mechanical properties. These new technologies offer rapid prototyping advantages and find applications in various fields, including biomedical devices, prosthetics, metamaterials, and soft robotics. Stereolithography (SLA) is a complementary approach with the ability to print with finer features and potentially higher throughput. However, all high-performance silicone elastomers are composites of polysiloxane networks reinforced with particulate filler, and consequently, silicone resins tend to have high viscosities (gel- or paste-like), which complicates or completely inhibits the layer-by-layer recoating process central to most SLA technologies. Herein, the design and build of a digital light projection SLA printer suitable for handling high-viscosity resins is demonstrated. Further, a series of UV-curable silicone resins with thiol-ene crosslinking and reinforced by a combination of fumed silica and MQ resins are also described. The resulting silicone elastomers are shown to have tunable mechanical properties, with 100–350% elongation and ultimate tensile strength from 1 to 2.5 MPa. Three-dimensional printed features of 0.4 mm were achieved, and complexity is demonstrated by octet-truss lattices that display negative stiffness.

107 The Role of Tissue Engineering in Auricular Reconstruction: A Critical Review

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
F Moura ◽  
R Varley ◽  
C Yao
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Immune Response ◽  
Critical Review ◽  
3D Bioprinting ◽  
Short Term ◽  
Auricular Reconstruction ◽  
Cartilage Reconstruction ◽  
Promising Solution

Abstract Aim Despite several decades of research in tissue engineering, reconstructing a 3D human-sized ear that can stand the test of time has remained a challenge. Autologous cartilage reconstruction remains the main treatment choice despite the associated morbidity. Progress in the field has been made and several studies have used tissue-engineered implants in immunocompetent animals with promising results. Method This study critically reviews and assesses the characteristics that make auricular reconstruction so challenging and how far research has come in addressing the following: mechanical properties; vascularisation; immune response; cell sourcing; surgical attachments; allografts; and cost. Results The question is whether tissue engineering will realistically replace autologous cartilage reconstruction in the short-term, or will advances in other areas, outlined in this article, manage to provide suitable and aesthetically accurate scaffolds. Conclusions Advances in tissue engineering are slowly progressing and utilise advances in both biomaterial design and 3D bioprinting to try and address the challenges of auricular reconstruction. Tissue engineering is still a promising solution to auricular reconstruction but still requires further research before becoming a reality.

Biomimetic porous Mg with tunable mechanical properties and biodegradation rates for bone regeneration

2019 ◽  
Vol 84 ◽  
pp. 453-467 ◽  
Author(s):  
Min-Ho Kang ◽  
Hyun Lee ◽  
Tae-Sik Jang ◽  
Yun-Jeong Seong ◽  
Hyoun-Ee Kim ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Tunable Mechanical Properties

Plastic-like Hydrogels with Reversible Conversion of Elasticity and Plasticity and Tunable Mechanical Properties

2019 ◽  
Vol 11 (44) ◽  
pp. 41659-41667 ◽  
Author(s):  
Jinrong Wang ◽  
Zhuo Chen ◽  
Xueyan Li ◽  
Mingjie Liu ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tunable Mechanical Properties

3D magnetic printing of bio-inspired composites with tunable mechanical properties

2018 ◽  
Vol 53 (20) ◽  
pp. 14274-14286 ◽  
Author(s):  
Luquan Ren ◽  
Xueli Zhou ◽  
Qingping Liu ◽  
Yunhong Liang ◽  
Zhengyi Song ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tunable Mechanical Properties

scholarly journals The Effect of Agarose on 3D Bioprinting

Polymers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 4028
Author(s):  
Chi Gong ◽  
Zhiyuan Kong ◽  
Xiaohong Wang
Keyword(s):  
Mechanical Properties ◽  
Low Temperature ◽  
Internal Structure ◽  
Three Dimensional ◽  
3D Bioprinting ◽  
Two Temperatures ◽  
Formed Structure ◽  
Accuracy And Stability ◽  
Physical Crosslinking ◽  
Complex Organ

In three-dimensional (3D) bioprinting, the accuracy, stability, and mechanical properties of the formed structure are very important to the overall composition and internal structure of the complex organ. In traditional 3D bioprinting, low-temperature gelatinization of gelatin is often used to construct complex tissues and organs. However, the hydrosol relies too much on the concentration of gelatin and has limited formation accuracy and stability. In this study, we take advantage of the physical crosslinking of agarose at 35–40 °C to replace the single pregelatinization effect of gelatin in 3D bioprinting, and printing composite gelatin/alginate/agarose hydrogels at two temperatures, i.e., 10 °C and 24 °C, respectively. After in-depth research, we find that the structures manufactured by the pregelatinization method of agarose are significantly more accurate, more stable, and harder than those pregelatined by gelatin. We believe that this research holds the potential to be widely used in the future organ manufacturing fields with high structural accuracy and stability.

Sign in / Sign up

Export Citation Format

Share Document