Silica Nanoparticles Coated with Smaller Au Nanoparticles for the Enhancement of Optical Oxygen Sensing

A simple, sensitive SERS-based immunoassay realized in aqueous solution is demonstrated with a sandwich immune protocol. In such an immunoassay, antibodies-immobilized silica nanoparticles served as the immune substrate while 4MBA-labeled immuno-Au nanoparticles are used as the immune sensors. According to the TEM images, it is clear that the immune gold nanoparticles are embedded onto the surfaces of the silica nanoparticles specifically after the immunoreaction. As a result, the aggregations of gold nanoparticles have been formed with SERS-active "hot spots" on the dimers or multimers. The SERS results confirm that the method proposed in this paper is an effective way for SERS-based aqueous immunoassay and that the detection limit is as low as 0.1 ng/mL.

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Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles

ACS Nano ◽

10.1021/acsnano.7b01006 ◽

2017 ◽

Vol 11 (6) ◽

pp. 5623-5632 ◽

Cited By ~ 15

Author(s):

Amani L. Lee ◽

Clifford T. Gee ◽

Bradley P. Weegman ◽

Samuel A. Einstein ◽

Adam R. Juelfs ◽

...

Keyword(s):

Silica Nanoparticles ◽

Oxygen Sensing ◽

Mesostructured Silica

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Enhancement of Au Nanoparticles Formed by in Situ Electrodeposition on Direct Electrochemistry of Myoglobin Loaded into Layer-by-Layer Films of Chitosan and Silica Nanoparticles

The Journal of Physical Chemistry B ◽

10.1021/jp807452z ◽

2008 ◽

Vol 112 (48) ◽

pp. 15513-15520 ◽

Cited By ~ 19

Author(s):

Xihong Guo ◽

Dong Zheng ◽

Naifei Hu

Keyword(s):

Silica Nanoparticles ◽

Au Nanoparticles ◽

Direct Electrochemistry ◽

Layer By Layer

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A Facile Method to Synthesis Hollow Silica Ellipsoids and Their Derivatives

MRS Proceedings ◽

10.1557/opl.2012.1342 ◽

2012 ◽

Vol 1453 ◽

Author(s):

Henan Zhang ◽

Daniel L. Akins

Keyword(s):

Silica Nanoparticles ◽

Chemical Etching ◽

Au Nanoparticles ◽

Silica Surface ◽

Hollow Silica ◽

Synthesis Conditions ◽

Wet Chemical ◽

Wet Chemical Etching

ABSTRACTWe have utilized wet-chemical etching of ellipsoidal silica nanoparticles to form silica nanoshells of a range of elliptical morphologies. The thicknesses of the silica ellipsoidal nanoshells are controlled through variation of synthesis conditions. A mechanism has been proposed to explain how the nanoshells are formed, and we have demonstrated that the porosity of the silica ellipsoid plays a role in the dissolution-regrowth process. We have also, via appropriate functionalization of the silica surface, coated the ellipsoidal nanoshells with Au nanoparticles.

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