Controllable Synthesis of Vacancy-Defect Cu Site and Its Catalysis for the Manufacture of Vinyl Chloride Monomer

ACS Catalysis ◽  
2021 ◽  
pp. 11016-11028
Author(s):  
Bolin Wang ◽  
Zhao Jiang ◽  
Ting Wang ◽  
Qi Tang ◽  
Mingde Yu ◽  
...  



Author(s):  
Barry S. Levy

This chapter describes occupational and environmental liver disorders. It describes the types of liver function and types of liver damage, and how these functions and this damage can be assessed. Workers in healthcare and solid waste management are at increased risk hepatitis B virus and hepatitis C virus infections. Occupational exposure to swine is associated with hepatitis E virus infection. More than 100 industrial chemicals can be acutely hepatotoxic in experimental animals or humans. Metabolic reactions may affect the hepatotoxicity of chemicals. Occupational exposure to organic solvents can cause toxic hepatitis. Occupational exposure to vinyl chloride monomer has been causally associated with toxicant-associated fatty liver disease as well as a form of non-cirrhotic portal hypertension. Several agents can cause cancer of the liver or bile ducts. Vinyl chloride monomer is causally associated with angiosacoma of the liver. Arsenic causes liver cancer. Dietary exposure to aflatoxins can cause hepatoceulluar carcinoma.



2021 ◽  
pp. 074823372110155
Author(s):  
Weizhe Pan ◽  
Shengnan Yu ◽  
Jin Jia ◽  
Junyang Hu ◽  
Liang Jie ◽  
...  

Vinyl chloride (VC) is a confirmed human carcinogen associated with hepatocellular carcinoma and angiosarcoma. However, the role of microRNAs (miRNAs) in liver cell cycle changes under VC exposure remains unclear, which prevents research on the mechanism of VC-induced carcinogenesis. In this study, male rats were injected intraperitoneally with VC (0, 5, 25, and 125 mg/kg body weight) for 6, 8, and 12 weeks. Cell cycle analysis of liver cells, miRNA-222, miRNA-199a, miRNA-195, and miRNA-125b expression in the liver and serum, and target protein expression were performed at different time points. The results showed a higher percentage of hepatocytes in the G1/G0 and S phases at the end of 6 and 12 weeks of VC exposure, respectively. MiRNA-222 expression decreased initially and then increased, whereas miRNA-199a, miRNA-195, and miRNA-125b expression increased initially and then decreased, which corresponded with changes in cell cycle distribution and related target proteins expression (p27, cyclinA, cyclinD1, and CDK6). The corresponding expression levels of miRNAs in serum did not change. Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC.



2017 ◽  
Vol 53 (86) ◽  
pp. 11733-11746 ◽  
Author(s):  
Grazia Malta ◽  
Simon J. Freakley ◽  
Simon A. Kondrat ◽  
Graham J. Hutchings

The replacement of mercuric chloride in the production of vinyl chloride monomer, a precursor to PVC, would greatly reduce the environmental impact of this large scale industrial process.



Catalysts ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 276 ◽  
Author(s):  
Xing Li ◽  
Haiyang Zhang ◽  
Baochang Man ◽  
Chuanming Zhang ◽  
Hui Dai ◽  
...  


1979 ◽  
Vol 17 (3) ◽  
pp. 153-185
Author(s):  
Hiromichi HASEGAWA ◽  
Mitsuo SATO ◽  
Kuniaki OKONOGI ◽  
Akira SHIMAOKA ◽  
Hiroshi TSURUTA


Author(s):  
Nabil M. Fayad ◽  
Sami Y. Sheikheldin ◽  
Muhammad H. Al‐Malack ◽  
Aarif H. El‐Mubarak ◽  
Naseem Khaja


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