scholarly journals Potential Therapeutic Applications for Inhibitors of Autotaxin, a Bioactive Lipid-Producing Lysophospholipase D, in Disorders Affecting the Nervous System

2018 ◽  
Vol 9 (3) ◽  
pp. 398-400 ◽  
Author(s):  
Deron R. Herr ◽  
Jolin Hwee-Jing Ong ◽  
Wei-Yi Ong
Keyword(s):  
Nervous System ◽  
Therapeutic Applications ◽  
Lysophospholipase D

scholarly journals Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

2009 ◽  
Vol 30 (1) ◽  
pp. 15-35 ◽  
Author(s):  
Jason S Weinstein ◽  
Csanad G Varallyay ◽  
Edit Dosa ◽  
Seymur Gahramanov ◽  
Bronwyn Hamilton ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Therapeutic Applications

Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS). They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood–brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature using perfusion-weighted MRI sequences, and in vivo cellular tracking in CNS disease or injury. Novel, targeted, nanoparticle synthesis strategies will allow for a rapidly expanding range of applications in patients with brain tumors, cerebral ischemia or stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, and epilepsy. These strategies may ultimately improve disease detection, therapeutic monitoring, and treatment efficacy especially in the context of antiangiogenic chemotherapy and antiinflammatory medications. The purpose of this review is to outline the current status of superparamagnetic iron oxide nanoparticles in the context of biomedical nanotechnology as they apply to diagnostic MRI and potential therapeutic applications in neurooncology and other CNS inflammatory conditions.

scholarly journals Oksitosien: ’n kort oorsig

1993 ◽  
Vol 12 (3) ◽  
pp. 61-66
Author(s):  
P. F. Levay ◽  
M. Viljoen ◽  
H. S. Meij
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Physiological Role ◽  
Short Review ◽  
Milk Ejection ◽  
Pain Anxiety ◽  
Therapeutic Applications ◽  
Males And Females

Oxytocin is traditionally associated with parturition and lactation. The similarity in oxytocin plasma levels in males and females implies a wider physiological role for the hormone. Oxytocin would now appear to be involved not only in milk ejection, but also in the production of milk. The hormone has further been shown to play a paracrine role in menstruation and to be of importance for normal fertilisation. Several endocrine modulatory as well as neurotransmitter effects have also been reported for oxytocin. The discovery of the role of oxytocin in central nervous system processes such as pain, anxiety, memory and learning has stimuluted a search for possible therapeutic applications of oxytocin in cases such as chronic pain and Alzheimer’s disease. A short review is presented of some of the biochemical and physiological aspects underlying the functions and possible therapeutic applications of oxytocin.

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