scholarly journals Oksitosien: ’n kort oorsig

1993 ◽  
Vol 12 (3) ◽  
pp. 61-66
Author(s):  
P. F. Levay ◽  
M. Viljoen ◽  
H. S. Meij
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Physiological Role ◽  
Short Review ◽  
Milk Ejection ◽  
Pain Anxiety ◽  
Therapeutic Applications ◽  
Males And Females

Oxytocin is traditionally associated with parturition and lactation. The similarity in oxytocin plasma levels in males and females implies a wider physiological role for the hormone. Oxytocin would now appear to be involved not only in milk ejection, but also in the production of milk. The hormone has further been shown to play a paracrine role in menstruation and to be of importance for normal fertilisation. Several endocrine modulatory as well as neurotransmitter effects have also been reported for oxytocin. The discovery of the role of oxytocin in central nervous system processes such as pain, anxiety, memory and learning has stimuluted a search for possible therapeutic applications of oxytocin in cases such as chronic pain and Alzheimer’s disease. A short review is presented of some of the biochemical and physiological aspects underlying the functions and possible therapeutic applications of oxytocin.

scholarly journals NEUROMODULATOR LIGAND-RECEPTOR SYSTEM TIP39 - PTH2R

2020 ◽  
Vol 10 (2) ◽  
pp. 78-85
Author(s):  
A. N. Kurzanov ◽  
I. M. Bykov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Signal Transmission ◽  
Physiological Role ◽  
Receptor System ◽  
Axon Terminals ◽  
Nociceptive Information ◽  
The Central Nervous System ◽  
Anxiety Depression

Widely spread axon terminals of TIP39 neurons have a distribution similar to PTH2R containing neurons and their fibers which provides an anatomic base of neuromodulation action of TIP39. This functional and anatomic link- ing lets state that TIP39 and PTH2R form a neuromodulator ligand-receptor system. Basing on mechanisms of signal transmission used by TIP39 and PTH2R, they can form a neuromodulator system in many brain parts. TIP39-PTH2R system is a unique neuropeptide-receptor system, which localization and functions in the central nervous system differ from any other neuropeptides. Neuromodulator system TIP39-PTH2R predominantly participates in neuroendocrinal modulation by affecting the endocrinal system by means of its presence in several areas of hypothalamus. TIP39 influences neurons that contain somatostatin and corticotropin-releasing hormone. TIP39 can affect the release of adrenocorticotropin, luteinizing hormone, growth hormone and arginine-vasopressin from hypophysis. Experimental data prove that TIP39 modulates regulatory network of anxiety and depression, several aspects of stress reaction and also controls body temperature, participates in processing of auditory and nociceptive information. Physiological role of TIP39-PTH2R system is still to some extent unknown. However, distribution of PTH2R and TIP39 in tissues outside central nervous system assumes other potential physiological effects for this signal way. It is assumed that TIP39- PTH2R system should be probably considered as a potential therapeutic target for treatment of anxiety, depression and chronic pain, control and correction of neuroendocrine disruptions.

Evidence for a physiological role of nerve growth factor in the central nervous system of neonatal rats

Neuron ◽  
1989 ◽  
Vol 3 (3) ◽  
pp. 267-273 ◽  
Author(s):  
G. Vantini ◽  
N. Schiavo ◽  
A. Di Martino ◽  
P. Polato ◽  
C. Triban ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Physiological Role ◽  
Neonatal Rats ◽  
Nerve Growth ◽  
The Central Nervous System

scholarly journals The physiological role of vitamin D and the significance of its deficiency in the pathogenesis of climacteric syndrome

2018 ◽  
Vol 67 (3) ◽  
pp. 74-82 ◽  
Author(s):  
Yulia E. Morozova ◽  
Marina A. Tarasova
Keyword(s):  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Literature Review ◽  
Affective Disorders ◽  
Physiological Role ◽  
Climacteric Syndrome ◽  
The Central Nervous System ◽  
The Impact

This literature review summarizes data on the physiological role of vitamin D in women during menopause. We discuss the peculiarities of climacteric syndrome affected by vitamin D deficiency, including the impact of the vitamin on the central nervous system and its role in cognitive and affective disorders. The necessity of vitamin D therapy to prevent pathologies associated with menopause is highlighted.

Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain

2007 ◽  
Vol 293 (3) ◽  
pp. H1416-H1424 ◽  
Author(s):  
Lenice K. Becker ◽  
Gisele M. Etelvino ◽  
Thomas Walther ◽  
Robson A. S. Santos ◽  
Maria J. Campagnole-Santos
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Physiological Role ◽  
Ventrolateral Medulla ◽  
Hypothalamic Nucleus ◽  
Hypoglossal Nucleus ◽  
Anatomical Basis ◽  
Male Wistar Rats ◽  
The Central Nervous System

The G protein-coupled receptor Mas was recently described as an angiotensin-(1–7) [ANG-(1–7)] receptor. In the present study we evaluated the anatomical localization of Mas using immunofluorescence in the central nervous system of adult male Wistar rats. An abundant labeling was found in the hippocampus, amigdala, anterodorsal thalamic nucleus, cortex, and hypoglossal nucleus. More importantly, a dense ANG-(1–7) receptor Mas immunoreactivity was observed in cardiovascular-related areas of the medulla and forebrain, shown in several previous studies as sites for the action of ANG-(1–7) in the brain. A strong staining was found in the nucleus of the solitary tract, caudal and rostral ventrolateral medulla, inferior olive, parvo and magnocellular portions of the paraventricular hypothalamic nucleus, supraoptic nucleus, and lateral preoptic area. Furthermore, Mas staining was predominantly present in neurons. At the medullary sites, a specific and high-intensity binding for rhodamine-ANG-(1–7) was also shown. The specific ANG-(1–7) binding was completely displaced by the anti-Mas antibody or by the ANG-(1–7) antagonist, A-779. The data presented provide the first anatomical basis for the physiological role of ANG-(1–7)/Mas axis in the modulation of different cardiovascular functions and give new insights for clarifying the role of ANG-(1–7) in the central nervous system.

Sign in / Sign up

Export Citation Format

Share Document