Computational Insight into the Binding Profile of the Second-Generation PET Tracer PI2620 with Tau Fibrils

2020 ◽  
Vol 11 (6) ◽  
pp. 900-908 ◽  
Author(s):  
Guanglin Kuang ◽  
N. Arul Murugan ◽  
Yang Zhou ◽  
Agneta Nordberg ◽  
Hans Ågren
Keyword(s):  
Second Generation ◽  
Binding Profile ◽  
Pet Tracer ◽  
Insight Into ◽  
Tau Fibrils

Torah lishmah as a Central Concept in the Degel maḥaneh Efrayim of Moses Hayyim Ephraim of Sudylkow

1996 ◽  
pp. 258-267
Author(s):  
Roland Goetschel
Keyword(s):  
Second Generation ◽  
Sources Of Information ◽  
Stages Of Development ◽  
Central Concept ◽  
Family Connections ◽  
Ulterior Motives ◽  
Insight Into

This chapter focuses on R. Moses Hayyim Ephraim of Sudylkow, who is one of the most important figures in the second generation of the hasidic movement. This is due in part to his family connections. But an even more important factor in accounting for his status is the numerous passages in his collected teachings, the Degel maḥaneh Efrayim, where he reports statements in the name of such hasidic luminaries as the Baal Shem Tov, R. Jacob Joseph of Polonnoye, R. Nahman of Horodenka, and the Maggid of Mezhirech, making him one of the most valuable sources of information on the hasidic doctrine at its earliest stages of development. The Degel maḥaneh Efrayim is also important for another reason, in that it provides an insight into R. Moses Hayyim Ephraim's own method of integrating into his sermons the main themes of hasidic revivalism. The chapter then considers the torah lishmah—study of Torah ‘for its own sake’, without ulterior motives—as a central concept in R. Moses Hayyim Ephraim's work. It also looks at the significance of torah lishmah in the controversy between hasidism and mitnaggedim.

scholarly journals Traditional Electricity Systems in Spain: Fensa (1927-1991)

2012 ◽  
Vol 30 (2) ◽  
pp. 245-285 ◽  
Author(s):  
Josean Garrués-Irurzun
Keyword(s):  
Comparative Advantage ◽  
Economic History ◽  
Second Generation ◽  
Electricity Sector ◽  
Limited Size ◽  
European Economic ◽  
Regional Markets ◽  
Different Types ◽  
Electricity Systems ◽  
Insight Into

AbstractBecause the literature of European economic history has paid little attention to traditional electricity systems, the interest in studying Fensa lies in analysing the different types of companies, which helped to shape the development of the Spanish electricity sector prior to its present oligopolistic structure. This case provides insight into two issues. First, we learn about the behaviour of the second-generation companies (those that based their production on a controlled hydropower regime), which, despite their limited size, made their commercial specialisation (supplying the dynamic industrial market of Guipúzcoa) their main comparative advantage. Second, we analyse the behaviour of those companies which at this time, as distribution companies and/or subsidiaries of the large Spanish companies (Iberduero), were an instrument of the policy of integrating regional markets.

Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine

2001 ◽  
Vol 50 (5) ◽  
pp. 345-350 ◽  
Author(s):  
Michael J Owens ◽  
David L Knight ◽  
Charles B Nemeroff
Keyword(s):  
Second Generation ◽  
Monoamine Transporter ◽  
Binding Profile

scholarly journals Identity and difference – re-thinking UK South Asian entrepreneurship

2017 ◽  
Vol 11 (5) ◽  
pp. 564-589
Author(s):  
Mark Christopher McPherson
Keyword(s):  
South Asian ◽  
First Generation ◽  
Second Generation ◽  
Cultural Perspective ◽  
Structured Interviews ◽  
Content Type ◽  
The Uk ◽  
First And Second Generation ◽  
Identity And Difference ◽  
Insight Into

Purpose This paper, which is part of a larger study, aims to discuss from an ethno-cultural perspective, the notion of self-identification and difference pertaining to first and second-generation South Asian male entrepreneurs. In essence, previous studies have not explored this dimension to any sufficient depth. Therefore, evidence is unclear as to how ethno-culture has informed entrepreneurial identity and difference. Design/methodology/approach Adopting a phenomenological research paradigm, 42 semi-structured interviews were conducted with first- and second-generation Sikh and Pakistani Muslim male entrepreneurs in Greater London. A typology of second-generation entrepreneurs is developed and a research agenda proposed. Findings First-generation respondents regard the UK as home and do not suffer from shifts in identity. These particular respondents identify themselves as Sikh or Pakistani Muslim or a Businessman. However, the second-generation identify themselves via three distinct labels. Here respondents stress their ethnicity by using Hyphenated British identities or hide their ethnicity behind the term a Normal Businessman, or appear opportunists by using ethnicity as a resource to espouse a true entrepreneurial identity. Research limitations/implications The research environment within the Greater London area where the respondents are located may not be as generalisable when compared with other parts of the UK. Originality/value This paper offers a unique insight into self-prescribed identity and difference noted among London’s ethnic entrepreneurs.

scholarly journals Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Adriana Savastano ◽  
Garima Jaipuria ◽  
Loren Andreas ◽  
Eckhard Mandelkow ◽  
Markus Zweckstetter
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid State ◽  
Solid State Nmr ◽  
Amyloid Fibrils ◽  
Dimensional Structure ◽  
Rich Region ◽  
Insight Into ◽  
Proline Rich Region ◽  
Tau Fibrils

AbstractThe aggregation of hyperphosphorylated tau into amyloid fibrils is closely linked to the progression of Alzheimer’s disease. To gain insight into the link between amyloid structure and disease, the three-dimensional structure of tau fibrils has been studied using solid-state NMR (ssNMR) and cryogenic electron microscopy (cryo-EM). The proline-rich region of tau remains poorly defined in the context of tau amyloid structures, despite the clustering of several phosphorylation sites, which have been associated with Alzheimer’s disease. In order to gain insight into the contribution of the proline-rich region P2 of tau to amyloid fibrils, we studied in vitro aggregated amyloid fibrils of tau constructs, which contain both the proline-rich region P2 and the pseudo-repeats. Using ssNMR we show that the sequence $$^{225}{\text {KVAVVRT}}^{231}$$ 225 KVAVVRT 231 , the most hydrophobic patch within the P2 region, loses its flexibility upon formation of amyloid fibrils. The data suggest a contribution of the P2 region to tau amyloid fibril formation, which might account for some of the unassigned electron density in cryo-EM studies of tau fibrils and could be modulated by tau phosphorylation at the disease-associated AT180 epitope T231/S235.

scholarly journals The First Insight into the Tissue Specific Taxus Transcriptome via Illumina Second Generation Sequencing

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e21220 ◽  
Author(s):  
Da Cheng Hao ◽  
GuangBo Ge ◽  
PeiGen Xiao ◽  
YanYan Zhang ◽  
Ling Yang
Keyword(s):  
Second Generation ◽  
Tissue Specific ◽  
Second Generation Sequencing ◽  
Insight Into ◽  
Generation Sequencing

scholarly journals Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer’s Disease

2021 ◽  
Vol 14 (2) ◽  
pp. 110
Author(s):  
Caitlin Jie ◽  
Valerie Treyer ◽  
Roger Schibli ◽  
Linjing Mu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Pet Imaging ◽  
Second Generation ◽  
Tau Proteins ◽  
Tau Pathology ◽  
Pet Tracer ◽  
Positron Emission ◽  
Tau Pet ◽  
Target Binding

Tauvid has been approved by the U.S. Food and Drug Administration (FDA) in 2020 for positron emission tomography (PET) imaging of adult patients with cognitive impairments undergoing evaluation for Alzheimer’s disease (AD) based on tau pathology. Abnormal aggregation of tau proteins is one of the main pathologies present in AD and is receiving increasing attention as a diagnostic and therapeutic target. In this review, we summarised the production and quality control of Tauvid, its clinical application, pharmacology and pharmacokinetics, as well as its limitation due to off-target binding. Moreover, a brief overview on the second-generation of Tau PET tracers is provided. The approval of Tauvid marks a step forward in the field of AD research and opens up opportunities for second-generation tau tracers to advance tau PET imaging in the clinic.

scholarly journals IMO Second Generation Intact Stability Criteria: General Overview and Focus on Operational Measures

2020 ◽  
Vol 8 (7) ◽  
pp. 494
Author(s):  
Nicola Petacco ◽  
Paola Gualeni
Keyword(s):  
Second Generation ◽  
Methodological Approach ◽  
Ship Design ◽  
Stability Assessment ◽  
Stability Criteria ◽  
Comprehensive Overview ◽  
Complementary Action ◽  
Intact Stability ◽  
Insight Into ◽  
Operational Aspects

At the beginning of 2020, after a long and demanding process, the Second Generation Intact Stability criteria (SGISc) have been finalized at the 7th session of the International Maritime Organization (IMO) sub-committee on Ship Design and Construction (SDC). At present, SGISc are not mandatory, nevertheless IMO endorses their application in order to assess their consistency and validity. It is envisaged that SGISc can support the design of safer ships, nevertheless such a rules framework might have an impact also on the ship operational aspects in a seaway. In fact, within the SGISc framework, Operational Measures have also been implemented providing guidance and limitations during navigation. After a comprehensive overview about SGISc vulnerability levels and direct stability assessment, this paper provides a specific insight into the methodological approach for the Operational Measures extensively addressed as a complementary action to ship design.

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