scholarly journals Self-Assembling pH-Responsive Nanoparticle Platform Based on Pectin–Doxorubicin Conjugates for Codelivery of Anticancer Drugs

ACS Omega ◽  
2021 ◽  
Author(s):  
Yinghua Tao ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Kefeng Liu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Ph Responsive ◽  
Self Assembling

scholarly journals From Micelles to Fibers: Balancing Self-Assembling and Random Coiling Domains in pH-Responsive Silk-Collagen-Like Protein-Based Polymers

2014 ◽  
Vol 15 (9) ◽  
pp. 3349-3357 ◽  
Author(s):  
Lennart H. Beun ◽  
Ingeborg M. Storm ◽  
Marc W. T. Werten ◽  
Frits A. de Wolf ◽  
Martien A. Cohen Stuart ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Self Assembling

Tandem Molecular Self-assembly for Selective Lung Cancer Therapy with Two Orders of Magnitude Increase in Efficiency

Nanoscale ◽  
2021 ◽  
Author(s):  
Debin Zheng ◽  
Jingfei Liu ◽  
Yinghao Ding ◽  
Limin Xie ◽  
Yingying Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Self Assembly ◽  
Therapeutic Efficacy ◽  
Self Assembling ◽  
Lung Cancer Therapy ◽  
Magnitude Increase

In situ self-assembling of prodrug molecules into nanomedicine can elevate the therapeutic efficacy of anticancer medications by enhancing the targeting and enrichment of anticancer drugs at tumor sites. However, the...

Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs

2016 ◽  
Vol 4 (34) ◽  
pp. 5650-5653 ◽  
Author(s):  
Yuming Guo ◽  
Weili Jia ◽  
Han Li ◽  
Weike Shi ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Sustained Release ◽  
Green Synthesis ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Hollow Spheres ◽  
Ph Responsive

Calcium carbonate/folate porous hollow spheres were prepared in a facile manner and used for the targeted delivery and pH-responsive sustained release of anticancer drugs.

pH-Responsive Cotton Effects in the d–d Transition Band of Self-Assembling Copper(II) Complexes with a Cholesteryl-Armed Ligand

2017 ◽  
Vol 90 (6) ◽  
pp. 739-745 ◽  
Author(s):  
Takuya Sagami ◽  
Shota Umemoto ◽  
Yuhei O. Tahara ◽  
Makoto Miyata ◽  
Yusuke Yonamine ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Transition Band ◽  
Self Assembling ◽  
Cotton Effects

Microfluidic Synthesis of Lignin/Chitosan Nanoparticles for the pH-Responsive Delivery of Anticancer Drugs

Langmuir ◽  
2021 ◽  
Author(s):  
Yingying Chai ◽  
Yuefei Wang ◽  
Bingqi Li ◽  
Wei Qi ◽  
Rongxin Su ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Chitosan Nanoparticles ◽  
Ph Responsive

scholarly journals Self-Assembling Behavior of pH-Responsive Peptide A6K without End-Capping

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2017
Author(s):  
Peng Zhang ◽  
Fenghuan Wang ◽  
Yuxuan Wang ◽  
Shuangyang Li ◽  
Sai Wen
Keyword(s):  
Self Assembly ◽  
Md Simulation ◽  
Block Structure ◽  
Distribution Model ◽  
Ph Responsive ◽  
Random Coils ◽  
Self Assembling ◽  
C Terminus ◽  
Transmission Electron ◽  
End Capping

A short self-assembly peptide A6K (H2N−AAAAAAK−OH) with unmodified N− and C−terminus was designed, and the charge distribution model of this short peptide at different pH was established by computer simulation. The pH of the solution was adjusted according to the model and the corresponding self-assembled structure was observed using a transmission electron microscope (TEM). As the pH changes, the peptide will assemble into blocks or nanoribbons, which indicates that the A6K peptide is a pH-responsive peptide. Circular dichroism (CD) and molecular dynamics (MD) simulation showed that the block structure was formed by random coils, while the increase in β-turn content contributes to the formation of intact nanoribbons. A reasonable explanation of the self-assembling structure was made according to the electrostatic distribution model and the effect of electrostatic interaction on self-assembly was investigated. This study laid the foundation for further design of nanomaterials based on pH-responsive peptides.

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