Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs

2016 ◽  
Vol 4 (34) ◽  
pp. 5650-5653 ◽  
Author(s):  
Yuming Guo ◽  
Weili Jia ◽  
Han Li ◽  
Weike Shi ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Sustained Release ◽  
Green Synthesis ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Hollow Spheres ◽  
Ph Responsive

Calcium carbonate/folate porous hollow spheres were prepared in a facile manner and used for the targeted delivery and pH-responsive sustained release of anticancer drugs.

Hollow silica nanospheres coated with insoluble calcium salts for pH-responsive sustained release of anticancer drugs

2016 ◽  
Vol 52 (70) ◽  
pp. 10652-10655 ◽  
Author(s):  
Yuming Guo ◽  
Qilong Fang ◽  
Han Li ◽  
Weike Shi ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Drugs ◽  
Ph Sensitive ◽  
Silica Nanospheres ◽  
Ph Responsive ◽  
Calcium Salts ◽  
Hollow Silica ◽  
Hollow Silica Nanospheres

Hollow silica nanospheres coated with pH-sensitive insoluble calcium salts are prepared for pH-responsive sustained release of anticancer drugs.

scholarly journals Stabilization and Release of Palm Tocotrienol Emulsion Fabricated Using pH-Sensitive Calcium Carbonate

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 358
Author(s):  
Phui Yee Tan ◽  
Beng Ti Tey ◽  
Eng Seng Chan ◽  
Oi Ming Lai ◽  
Hon Weng Chang ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Droplet Size ◽  
Entrapment Efficiency ◽  
Ph Sensitive ◽  
Emulsion System ◽  
Ph Responsive ◽  
Small Droplet ◽  
Homogenization Time ◽  
Oil In Water ◽  
Ph Range

Calcium carbonate (CaCO3) has been utilized as a pH-responsive component in various products. In this present work, palm tocotrienols-rich fraction (TRF) was successfully entrapped in a self-assembled oil-in-water (O/W) emulsion system by using CaCO3 as the stabilizer. The emulsion droplet size, viscosity and tocotrienols entrapment efficiency (EE) were strongly affected by varying the processing (homogenization speed and time) and formulation (CaCO3 and TRF concentrations) parameters. Our findings indicated that the combination of 5000 rpm homogenization speed, 15 min homogenization time, 0.75% CaCO3 concentration and 2% TRF concentration resulted in a high EE of tocotrienols (92.59–99.16%) and small droplet size (18.83 ± 1.36 µm). The resulting emulsion system readily released the entrapped tocotrienols across the pH range tested (pH 1–9); with relatively the highest release observed at pH 3. The current study presents a potential pH-sensitive emulsion system for the entrapment and delivery of palm tocotrienols.

Targeted Delivery of Dual Anticancer Drugs Based on Self-Assembled iRGD-Modified Soluble Drug–Polymer Pattern Conjugate Nanoparticles

2021 ◽  
Vol 4 (2) ◽  
pp. 1499-1507
Author(s):  
Chunxiao Li ◽  
Zhenyu Chen ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Jiandu Lei
Keyword(s):  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Self Assembled

scholarly journals Self-Assembling pH-Responsive Nanoparticle Platform Based on Pectin–Doxorubicin Conjugates for Codelivery of Anticancer Drugs

ACS Omega ◽  
2021 ◽  
Author(s):  
Yinghua Tao ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Kefeng Liu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Ph Responsive ◽  
Self Assembling

Multivesicular liposome: A lipid-based drug delivery system for efficient drug delivery

2021 ◽  
Vol 27 ◽  
Author(s):  
Bapi Gorain ◽  
Bandar E. Al-Dhubiab ◽  
Anroop Nair ◽  
Prashant Kesharwani ◽  
Manisha Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Therapeutic Agents ◽  
Laboratory Research ◽  
Efficacy And Safety ◽  
Liposomal Delivery ◽  
Proteins And Peptides

: The advancement of delivery tools for therapeutic agents has brought several novel formulations with increased drug loading, sustained release, targeted delivery, and prolonged efficacy. Amongst the several novel delivery approaches, multivesicular liposome has gained potential interest because this delivery system possesses the above advantages. In addition, this multivesicular liposomal delivery prevents degradation of the entrapped drug within the physiological environment while administered. The special structure of the vesicles allowed successful entrapment of hydrophobic and hydrophilic therapeutic agents, including proteins and peptides. Furthermore, this novel formulation could maintain the desired drug concentration in the plasma for a prolonged period, which helps to reduce the dosing frequencies, improve bioavailability, and safety. This tool could also provide stability of the formulation, and finally gaining patient compliance. Several multivesicular liposomes received approval for clinical research, while others are at different stages of laboratory research. In this review, we have focused on the preparation of multivesicular liposomes along with their application in different ailments for the improvement of the performance of the entrapped drug. Moreover, the challenges of delivering multivesicular vesicles have also been emphasized. Overall, it could be inferred that multivesicular liposomal delivery is a novel platform of advanced drug delivery with improved efficacy and safety.

scholarly journals Formulation of a Sustained Release Docetaxel Loaded Cockle Shell-Derived Calcium Carbonate Nanoparticles against Breast Cancer

2017 ◽  
Vol 34 (6) ◽  
pp. 1193-1203 ◽  
Author(s):  
Nahidah Ibrahim Hammadi ◽  
Yusuf Abba ◽  
Mohd Noor Mohd Hezmee ◽  
Intan Shameha Abdul Razak ◽  
Alhaji Zubair Jaji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Calcium Carbonate ◽  
Sustained Release ◽  
Cockle Shell
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