Two Rat Surfactant Protein A Isoforms Arise by a Novel Mechanism That Includes Alternative Translation Initiation†

Biochemistry ◽  
2000 ◽  
Vol 39 (33) ◽  
pp. 10189-10195 ◽  
Author(s):  
Mamatha Damodarasamy ◽  
Mei Zhang ◽  
Krista Dienger ◽  
Francis X. McCormack
Keyword(s):  
Translation Initiation ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Alternative Translation Initiation ◽  
Alternative Translation

Screening and Identification of Aptamers Aganinst Pulmonary Surfactant Protein A

2013 ◽  
Vol 41 (11) ◽  
pp. 1659
Author(s):  
Li-Juan LIU ◽  
Yi CHEN ◽  
Wei WANG ◽  
Chao CHEN ◽  
Ming-Hao GAO ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Screening And Identification ◽  
Pulmonary Surfactant Protein

scholarly journals Surfactant protein A reduces TLR4 and inflammatory cytokine mRNA levels in neonatal mouse ileum

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lidan Liu ◽  
Chaim Z. Aron ◽  
Cullen M. Grable ◽  
Adrian Robles ◽  
Xiangli Liu ◽  
...  
Keyword(s):  
Proinflammatory Cytokine ◽  
Inflammatory Cytokine ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Mrna Levels ◽  
Wild Type ◽  
Cytokine Mrna ◽  
Protein Levels ◽  
Cytokine Levels

AbstractLevels of intestinal toll-like receptor 4 (TLR4) impact inflammation in the neonatal gastrointestinal tract. While surfactant protein A (SP-A) is known to regulate TLR4 in the lung, it also reduces intestinal damage, TLR4 and inflammation in an experimental model of necrotizing enterocolitis (NEC) in neonatal rats. We hypothesized that SP-A-deficient (SP-A−/−) mice have increased ileal TLR4 and inflammatory cytokine levels compared to wild type mice, impacting intestinal physiology. We found that ileal TLR4 and proinflammatory cytokine levels were significantly higher in infant SP-A−/− mice compared to wild type mice. Gavage of neonatal SP-A−/− mice with purified SP-A reduced ileal TLR4 protein levels. SP-A reduced expression of TLR4 and proinflammatory cytokines in normal human intestinal epithelial cells (FHs74int), suggesting a direct effect. However, incubation of gastrointestinal cell lines with proteasome inhibitors did not abrogate the effect of SP-A on TLR4 protein levels, suggesting that proteasomal degradation is not involved. In a mouse model of experimental NEC, SP-A−/− mice were more susceptible to intestinal stress resembling NEC, while gavage with SP-A significantly decreased ileal damage, TLR4 and proinflammatory cytokine mRNA levels. Our data suggests that SP-A has an extrapulmonary role in the intestinal health of neonatal mice by modulating TLR4 and proinflammatory cytokines mRNA expression in intestinal epithelium.

scholarly journals Binding of surfactant protein A (SP-A) to herpes simplex virus type 1-infected cells is mediated by the carbohydrate moiety of SP-A.

1992 ◽  
Vol 267 (35) ◽  
pp. 25039-25043 ◽  
Author(s):  
J.F. van Iwaarden ◽  
J.A. van Strijp ◽  
H Visser ◽  
H.P. Haagsman ◽  
J Verhoef ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Infected Cells ◽  
Simplex Virus

Peroxynitrite injury to surfactant protein a (SP-A)

1993 ◽  
Vol 15 (5) ◽  
pp. 501
Author(s):  
I. Haddad ◽  
J.S. Beckman ◽  
R. Garver ◽  
S. Matalon
Keyword(s):  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A
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