Akt-Dependent Antiapoptotic Action of Insulin Is Sensitive to Farnesyltransferase Inhibitor

Biochemistry ◽

10.1021/bi000995y ◽

2000 ◽

Vol 39 (41) ◽

pp. 12513-12521 ◽

Author(s):

Doekbae Park ◽

Sanjay K. Pandey ◽

Elena Maksimova ◽

Sutapa Kole ◽

Michel Bernier

Keyword(s):

Farnesyltransferase Inhibitor

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Phase I Trial and Pharmacokinetics Study of the Farnesyltransferase Inhibitor Tipifarnib in Children With Refractory Solid Tumors or Neurofibromatosis Type I and Plexiform Neurofibromas

Yearbook of Oncology ◽

10.1016/s1040-1741(08)70478-0 ◽

2007 ◽

Vol 2007 ◽

pp. 292-293

Author(s):

R.J. Arceci

Keyword(s):

Phase I ◽

Solid Tumors ◽

Phase I Trial ◽

Neurofibromatosis Type ◽

Type I ◽

Neurofibromatosis Type I ◽

Farnesyltransferase Inhibitor ◽

Plexiform Neurofibromas ◽

Pharmacokinetics Study

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Faculty Opinions recommendation of Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1097392.553443 ◽

2007 ◽

Author(s):

Channing Der

Keyword(s):

Farnesyltransferase Inhibitor ◽

Progeria Syndrome ◽

Hutchinson Gilford Progeria Syndrome

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Faculty Opinions recommendation of A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1108820.564950 ◽

2008 ◽

Author(s):

Arati Rao

Keyword(s):

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

Farnesyltransferase Inhibitor ◽

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Faculty Opinions recommendation of A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735400596.793558428 ◽

2019 ◽

Author(s):

Robert Petersen

Keyword(s):

Tau Pathology ◽

Farnesyltransferase Inhibitor

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The Farnesyltransferase Inhibitor LB42708 Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signal Pathways

Molecular Pharmacology ◽

10.1124/mol.110.063586 ◽

2010 ◽

Vol 78 (1) ◽

pp. 142-150 ◽

Author(s):

Chun-Ki Kim ◽

Yoon Kyung Choi ◽

Hansoo Lee ◽

Kwon-Soo Ha ◽

Moo-Ho Won ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Signal Pathways ◽

Vascular Endothelial ◽

Phosphatidylinositol 3 Kinase ◽

Farnesyltransferase Inhibitor ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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Anti-Inflammatory Activity in Vitro and in Vivo of the Protein Farnesyltransferase Inhibitor Tipifarnib

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.105.095976 ◽

2005 ◽

Vol 317 (1) ◽

pp. 53-60 ◽

Author(s):

Xiaohua Xue ◽

Kuei-Tai A. Lai ◽

Jing-Feng Huang ◽

Yin Gu ◽

Lars Karlsson ◽

...

Keyword(s):

Inflammatory Activity ◽

Farnesyltransferase Inhibitor ◽

Protein Farnesyltransferase ◽

Anti Inflammatory

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ChemInform Abstract: TAN-1813, a Novel Ras-Farnesyltransferase Inhibitor Produced by Phoma sp. Taxonomy, Fermentation, Isolation and Biological Activities in vitro and in vivo.

10.1002/chin.200103218 ◽

2001 ◽

Vol 32 (3) ◽

pp. no-no

Author(s):

Takafumi Ishii ◽

Kozo Hayashi ◽

Tsuneaki Hida ◽

Yasuharu Yamamoto ◽

Yukimasa Nozaki

Keyword(s):

Biological Activities ◽

Farnesyltransferase Inhibitor ◽

Ras Farnesyltransferase

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The Farnesyltransferase Inhibitor Lonafarnib Induces CCAAT/Enhancer-binding Protein Homologous Protein-dependent Expression of Death Receptor 5, Leading to Induction of Apoptosis in Human Cancer Cells

Journal of Biological Chemistry ◽

10.1074/jbc.m611438200 ◽

2007 ◽

Vol 282 (26) ◽

pp. 18800-18809 ◽

Author(s):

Shi-Yong Sun ◽

Xiangguo Liu ◽

Wei Zou ◽

Ping Yue ◽

Adam I. Marcus ◽

...

Keyword(s):

Cancer Cells ◽

Human Cancer ◽

Binding Protein ◽

Death Receptor ◽

Death Receptor 5 ◽

Farnesyltransferase Inhibitor ◽

Human Cancer Cells ◽

Homologous Protein ◽

Enhancer Binding Protein ◽

Induction Of Apoptosis

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ChemInform Abstract: Synthesis and in vitro Evaluation of the Ras Farnesyltransferase Inhibitor Pepticinnamin E.

10.1002/chin.199831212 ◽

2010 ◽

Vol 29 (31) ◽

pp. no-no

Author(s):

K. HINTERDING ◽

P. HAGENBUCH ◽

J. RETEY ◽

H. WALDMANN

Keyword(s):

Farnesyltransferase Inhibitor ◽

In Vitro Evaluation ◽

Ras Farnesyltransferase

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J-104,871, a Novel Farnesyltransferase Inhibitor, Blocks Ras Farnesylation In Vivo in a Farnesyl Pyrophosphate-Competitive Manner

Molecular Pharmacology ◽

10.1124/mol.54.1.1 ◽

1998 ◽

Vol 54 (1) ◽

pp. 1-7 ◽

Author(s):

Mari Yonemoto ◽

Toshihiko Satoh ◽

Hiroharu Arakawa ◽

Ikuko Suzuki-Takahashi ◽

Yoshiaki Monden ◽

...

Keyword(s):

Farnesyl Pyrophosphate ◽

Farnesyltransferase Inhibitor

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