1H NMR Studies of Interleukin 8 Analogs: Characterization of the Domains Essential for Function

The synthesis and characterization of 6A-deoxy-6A-(1,4,7-tri(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-10-yl)-β-cyclodextrin (1b) are reported. A fluorescence lifetime study of its Eu3+ complex (1c) is consistent with one water coordinating Eu3+ in addition to hepta-coordination by (1b). 1H NMR studies are consistent with (1b) forming host–guest complexes with (R/S)-histidinate (2a), (R/S)-tyrosinate (2b), (R/S)-phenylalaninate (2c), and (R/S)-tryptophanate (2d), with enantioselectivity shown for (2b). Similar studies are consistent with (1c) complexing (2a–d), with enantioselectivity shown for (2a).

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Synthesis and Spectral Characterization of New S-Alkylated 1,2,4-Triazoles as Potential Biological Agents

Revista de Chimie ◽

10.37358/rc.17.10.5900 ◽

2017 ◽

Vol 68 (10) ◽

pp. 2436-2439

Author(s):

Stefania Felicia Barbuceanu ◽

Laura Ileana Socea ◽

Constantin Draghici ◽

Elena Mihaela Pahontu ◽

Theodora Venera Apostol ◽

...

Keyword(s):

Mass Spectrometry ◽

Spectral Data ◽

1H Nmr ◽

Elemental Analysis ◽

13C Nmr ◽

Ethyl Bromide ◽

Spectral Characterization ◽

Basic Medium ◽

Phenacyl Bromide

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

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Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins

Letters in Organic Chemistry ◽

10.2174/1570178616666190212124838 ◽

2020 ◽

Vol 17 (2) ◽

pp. 85-89

Author(s):

Francisco J. Hidalgo ◽

Nathan A.P. Lorentz ◽

TinTin B. Luu ◽

Jonathan D. Tran ◽

Praveen D. Wickremasinghe ◽

...

Keyword(s):

Physicochemical Properties ◽

Dynamic Behavior ◽

Industrial Applications ◽

19F Nmr ◽

Nmr Studies ◽

Synthetic Pathway ◽

End Groups ◽

Sugar End

: Maltodextrins have an increasing number of biomedical and industrial applications due to their attractive physicochemical properties such as biodegradability and biocompatibility. Herein, we describe the development of a synthetic pathway and characterization of thiol-responsive maltodextrin conjugates with dithiomaleimide linkages. 19F NMR studies were also conducted to demonstrate the exchange dynamics of the dithiomaleimide-functionalized sugar end groups.

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1H NMR studies of [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in dimethylsulfoxide by nuclear Overhauser effect (NOE) enhancement spectroscopy: cis-trans Isomerism of the His-Pro bond

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19901106 ◽

1990 ◽

Vol 55 (4) ◽

pp. 1106-1111 ◽

Cited By ~ 1

Author(s):

John Matsoukas ◽

Paul Cordopatis ◽

Raghav Yamdagni ◽

Graham J. Moore

Keyword(s):

1H Nmr ◽

Nuclear Overhauser Effect ◽

Nmr Studies ◽

Restricted Rotation ◽

Overhauser Effect ◽

Major Isomer ◽

Conformational Properties ◽

Nuclear Overhauser

The conformational properties of the Sarmesin analogues [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in hexadeutero-dimethysulfoxide were investigated by Nuclear Overhauser Effect (NOE) Enhancement Studies. Cis-trans isomers (ratio 1 : 6) due to restricted rotation of the His-Pro bond were observed. Interresidue interactions between the His Cα proton and the two Pro Cδ protons revealed that the major isomer was the trans.

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