Protective and Inhibitory Effects of Various Types of Amphipols on the Ca2+-ATPase from Sarcoplasmic Reticulum:  A Comparative Study†

The inhibition by diethylstilboestrol of DNA nucleotidyltransferase isolated from calf thymus was studied. The inhibition exercised by diethylstilboestrol appears to obey competitive kinetics with respect to DNA primer. The activities of both replicative and terminal enzymes were affected to the same extent. There was no evidence of binding between DNA and diethylstilboestrol. A comparative study of the inhibitory effects of some stilboestrol derivatives is presented. The alkyl substitution in the αα′-positions seem to alter the inhibitory effect of these compounds: dimethylstilboestrol was more inhibitory than stilbene, and diethylstilboestrol was more inhibitory than dimethylstilboestrol. Hexoestrol, in which the αα′-ethylenic linkage is saturated, was the most effective inhibitor.

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Ultrastructure and architecture of the sarcoplasmic reticulum in frog sino-atrial fibres: A comparative study with various preparatory procedures

Journal of Molecular and Cellular Cardiology ◽

10.1016/s0022-2828(85)80091-2 ◽

1985 ◽

Vol 17 (1) ◽

pp. 43-56 ◽

Cited By ~ 8

Author(s):

M. Duvert ◽

A. Verna

Keyword(s):

Sarcoplasmic Reticulum ◽

Comparative Study

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Comparative study of the inhibitory effects of lotus seedpod oligomeric procyanidins on dietary AGE released from glycated casein during digestion

Food Research International ◽

10.1016/j.foodres.2021.110912 ◽

2021 ◽

pp. 110912

Author(s):

Qian Wu ◽

Yu Ouyang ◽

Yingna Feng ◽

Yingfei Kong ◽

Yinggang Liang ◽

...

Keyword(s):

Comparative Study ◽

Inhibitory Effects ◽

Lotus Seedpod

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Comparative Study on the Inhibitory Effects of Topical Application and Feeding of Different Egyptian Garlic Extracts on Chemically Induced Skin Tumors

Journal of Medical Sciences(Faisalabad) ◽

10.3923/jms.2001.81.86 ◽

2001 ◽

Vol 1 (2) ◽

pp. 81-86 ◽

Cited By ~ 1

Author(s):

M.M. El- Mofty ◽

A.E. Essawy ◽

M.H. Shwaireb ◽

A.M. Rizk ◽

J.M. Sorour ◽

...

Keyword(s):

Comparative Study ◽

Topical Application ◽

Skin Tumors ◽

Inhibitory Effects ◽

Chemically Induced

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A Comparative Study on the Inhibitory Effects of Different Parts and Chemical Constituents of Pomegranate on α-Amylase and α-Glucosidase

Phytotherapy Research ◽

10.1002/ptr.4913 ◽

2012 ◽

Vol 27 (11) ◽

pp. 1614-1620 ◽

Cited By ~ 43

Author(s):

Antony Kam ◽

Kong M. Li ◽

Valentina Razmovski-Naumovski ◽

Srinivas Nammi ◽

Jeffrey Shi ◽

...

Keyword(s):

Comparative Study ◽

Chemical Constituents ◽

Inhibitory Effects ◽

Different Parts

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Astragaloside IV Inhibits Membrane Ca2+ Current but Enhances Sarcoplasmic Reticulum Ca2+ Release

The American Journal of Chinese Medicine ◽

10.1142/s0192415x1750046x ◽

2017 ◽

Vol 45 (04) ◽

pp. 863-877 ◽

Cited By ~ 2

Author(s):

Mei-Mi Zhao ◽

Wen-Wen Lian ◽

Zhuo Li ◽

Dong-Xue Shao ◽

Si-Chong Chen ◽

...

Keyword(s):

Chinese Medicine ◽

Sarcoplasmic Reticulum ◽

Traditional Chinese Medicine ◽

Cardiac Myocytes ◽

Cardiac Disease ◽

H9c2 Cells ◽

Inhibitory Effects ◽

Astragaloside Iv ◽

Active Ingredients ◽

Dependent Inactivation

Astragaloside IV (AS-IV) is one of the active ingredients in Astragalus membrananceus (Huangqi), a traditional Chinese medicine. The present study investigated the effects of AS-IV on Ca[Formula: see text] handling in cardiac myocytes to elucidate its possible mechanism in the treatment of cardiac disease. The results showed that AS-IV at 1 and 10[Formula: see text][Formula: see text]M reduced KCl-induced [Ca[Formula: see text]]i increase ([Formula: see text] from 1.33[Formula: see text][Formula: see text][Formula: see text]0.04 (control, [Formula: see text] 28) to 1.22[Formula: see text][Formula: see text][Formula: see text]0.02 ([Formula: see text], [Formula: see text] 29) and 1.22[Formula: see text][Formula: see text][Formula: see text]0.02 ([Formula: see text] 0.01, [Formula: see text]), but it enhanced Ca[Formula: see text] release from SR ([Formula: see text] from 1.04[Formula: see text][Formula: see text][Formula: see text]0.01 (control, [Formula: see text]) to 1.44[Formula: see text][Formula: see text][Formula: see text]0.03 ([Formula: see text], [Formula: see text]) and 1.60[Formula: see text][Formula: see text][Formula: see text]0.04 ([Formula: see text] 0.01, [Formula: see text]0), in H9c2 cells. Similar results were obtained in native cardiomyocytes. AS-IV at 1 and 10[Formula: see text][Formula: see text]M inhibited L-type Ca[Formula: see text] current ([Formula: see text] from [Formula: see text]4.42[Formula: see text][Formula: see text][Formula: see text]0.58 pA/pF of control to [Formula: see text]2.25[Formula: see text][Formula: see text][Formula: see text]0.12 pA/pF ([Formula: see text] 0.01, [Formula: see text] 5) and [Formula: see text]1.78[Formula: see text][Formula: see text][Formula: see text]0.28 pA/pF ([Formula: see text] 0.01, [Formula: see text] 5) respectively, when the interference of [Ca[Formula: see text]]i was eliminated due to the depletion of SR Ca[Formula: see text] store by thapsigargin, an inhibitor of Ca[Formula: see text] ATPase. Moreover, when BAPTA, a rapid Ca[Formula: see text] chelator, was used, CDI (Ca[Formula: see text]-dependent inactivation) of [Formula: see text] was eliminated, and the inhibitory effects of AS-IV on ICaL were significantly reduced at the same time. These results suggest that AS-IV affects Ca[Formula: see text] homeostasis through two opposite pathways: inhibition of Ca[Formula: see text] influx through L-type Ca[Formula: see text] channel, and promotion of Ca[Formula: see text] release from SR.

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