Flame-Sprayed Superparamagnetic Bare and Silica-Coated Maghemite Nanoparticles:  Synthesis, Characterization, and Protein Adsorption−Desorption

2006 ◽  
Vol 18 (26) ◽  
pp. 6403-6413 ◽  
Author(s):  
Dan Li ◽  
Wey Yang Teoh ◽  
Cordelia Selomulya ◽  
Robert C. Woodward ◽  
Rose Amal ◽  
...  

2021 ◽  
Vol 26 (6) ◽  
pp. 715-726
Author(s):  
Francisco Romero-Gavilán ◽  
Andreia Cerqueira ◽  
Eduardo Anitua ◽  
Ricardo Tejero ◽  
Iñaki García-Arnáez ◽  
...  

AbstractCalcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant surfaces modifies the physicochemical characteristics at the implant–tissue interface and thus, the biological responses. The aim of this study is to examine how the dynamics of protein adsorption on these surfaces change over time. Titanium discs with and without Ca were incubated with human serum for 2 min, 180 min, and 960 min. The layer of proteins attached to the surface was characterised using nLC-MS/MS. The adsorption kinetics was different between materials, revealing an increased adsorption of proteins associated with coagulation and immune responses prior to Ca release. Implant–blood contact experiments confirmed the strong coagulatory effect for Ca surfaces. We employed primary human alveolar osteoblasts and THP-1 monocytes to study the osteogenic and inflammatory responses. In agreement with the proteomic results, Ca-enriched surfaces showed a significant initial inflammation that disappeared once the calcium was released. The distinct protein adsorption/desorption dynamics found in this work demonstrated to be useful to explain the differential biological responses between the titanium and Ca-ion modified implant surfaces. Graphic abstract





2015 ◽  
Vol 24 (11) ◽  
pp. 113601
Author(s):  
Xiao-Hang Su ◽  
Qun-Li Lei ◽  
Chun-Lai Ren


Author(s):  
Wan-Hsin Chang ◽  
Pei-Yi Liu ◽  
Dai-En Lin ◽  
Yuan-Ting Jiang ◽  
Chien-Ju Lu ◽  
...  




2012 ◽  
Vol 377 (1) ◽  
pp. 476-484 ◽  
Author(s):  
Suvajyoti Guha ◽  
Joshua R. Wayment ◽  
Mingdong Li ◽  
Michael J. Tarlov ◽  
Michael R. Zachariah


ChemPhysChem ◽  
2008 ◽  
Vol 9 (14) ◽  
pp. 2035-2041 ◽  
Author(s):  
Arnaud Glaria ◽  
Myrtil L. Kahn ◽  
Andrea Falqui ◽  
Pierre Lecante ◽  
Vincent Collière ◽  
...  


Author(s):  
Mritunjoy Prasad Ghosh ◽  
Trupti Vijay Muley ◽  
Shradha Roy ◽  
Sipun Mohanty ◽  
Samrat Mukherjee


2015 ◽  
Vol 104 (6) ◽  
pp. 1946-1959 ◽  
Author(s):  
Tatiana Perevozchikova ◽  
Hirsh Nanda ◽  
Douglas P. Nesta ◽  
Christopher J. Roberts


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