Temperature-sensitive hydrogel modified by polymerizable liquid crystal AAc-Brij-58: Optical and protein adsorption/desorption behaviors

2015 ◽  
Vol 89 ◽  
pp. 1-8 ◽  
Author(s):  
Pengfei Liu ◽  
Wenjun Gao ◽  
Qingsong Zhang ◽  
Kun Chen ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Protein Adsorption ◽  
Temperature Sensitive ◽  
Brij 58 ◽  
Temperature Sensitive Hydrogel ◽  
Adsorption Desorption

Thermo- and salt-responsive poly(NIPAm-co-AAc-Brij-58) microgels: adjustable size, stability under salt stimulus, and rapid protein adsorption/desorption

2015 ◽  
Vol 294 (3) ◽  
pp. 617-628 ◽  
Author(s):  
Yalong Liu ◽  
Lijuan Xing ◽  
Qingsong Zhang ◽  
Qifeng Mu ◽  
Pengfei Liu ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Brij 58 ◽  
Size Stability ◽  
Adsorption Desorption

Synthesis and characterization of novel pH-, ionic strength and temperature- sensitive hydrogel for insulin delivery

Polymer ◽  
2010 ◽  
Vol 51 (8) ◽  
pp. 1687-1693 ◽  
Author(s):  
Nadia Rasool ◽  
Tariq Yasin ◽  
Jerry Y.Y. Heng ◽  
Zareen Akhter
Keyword(s):  
Ionic Strength ◽  
Insulin Delivery ◽  
Synthesis And Characterization ◽  
Temperature Sensitive ◽  
Temperature Sensitive Hydrogel

scholarly journals Protein adsorption/desorption dynamics on Ca-enriched titanium surfaces: biological implications

2021 ◽  
Vol 26 (6) ◽  
pp. 715-726
Author(s):  
Francisco Romero-Gavilán ◽  
Andreia Cerqueira ◽  
Eduardo Anitua ◽  
Ricardo Tejero ◽  
Iñaki García-Arnáez ◽  
...  
Keyword(s):  
Immune Responses ◽  
Protein Adsorption ◽  
Calcium Ions ◽  
Inflammatory Responses ◽  
Titanium Implant ◽  
Physicochemical Characteristics ◽  
Biological Responses ◽  
Titanium Surfaces ◽  
Tissue Interface ◽  
Adsorption Desorption

AbstractCalcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant surfaces modifies the physicochemical characteristics at the implant–tissue interface and thus, the biological responses. The aim of this study is to examine how the dynamics of protein adsorption on these surfaces change over time. Titanium discs with and without Ca were incubated with human serum for 2 min, 180 min, and 960 min. The layer of proteins attached to the surface was characterised using nLC-MS/MS. The adsorption kinetics was different between materials, revealing an increased adsorption of proteins associated with coagulation and immune responses prior to Ca release. Implant–blood contact experiments confirmed the strong coagulatory effect for Ca surfaces. We employed primary human alveolar osteoblasts and THP-1 monocytes to study the osteogenic and inflammatory responses. In agreement with the proteomic results, Ca-enriched surfaces showed a significant initial inflammation that disappeared once the calcium was released. The distinct protein adsorption/desorption dynamics found in this work demonstrated to be useful to explain the differential biological responses between the titanium and Ca-ion modified implant surfaces. Graphic abstract

scholarly journals Precise and handy measurement of the temperature profile appearing on a temperature-sensitive liquid-crystal film.

1991 ◽  
Vol 57 (533) ◽  
pp. 262-267
Author(s):  
Hideo KIMOTO ◽  
Hiroyoshi IZUKA ◽  
Kenji HAMABE
Keyword(s):  
Liquid Crystal ◽  
Temperature Profile ◽  
Temperature Sensitive ◽  
Crystal Film

Interactions between temperature-sensitive hydrogel microspheres and granulocytes

1995 ◽  
Vol 6 (7) ◽  
pp. 534-540 ◽  
Author(s):  
Koji Achiha ◽  
Rika Ojima ◽  
Yuji Kasuya ◽  
Keiji Fujimoto ◽  
Haruma Kawaguchi
Keyword(s):  
Temperature Sensitive ◽  
Temperature Sensitive Hydrogel ◽  
Hydrogel Microspheres

Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure

2010 ◽  
Vol 148-149 ◽  
pp. 1427-1430 ◽  
Author(s):  
Kui Lin Deng ◽  
Li Rong Dong ◽  
Yu E Shi ◽  
Yu Bo Gou ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Phosphate Buffer Solution ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Bead ◽  
The Core ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Biomedical Fields

As a drug delivery carrier, a novel pH/temperature sensitive bead (pTSB) with core-shelled structure from poly(N-acryloylglycine) (PAG), copoly(N-acryloylglycine methyl este and N-acryloylglycine ethyl ester) was prepared by two steps. In pH=7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the pTSB was about 60.1 % within 500 mins, but this value only reached to 22.3 % in pH=2.1 PBS. The release behaviors of indomethacin from pTSB also exhibited a remarkable dependence on PAG content in the core. Additionally, the release rate of indomethacin was much faster at 18 oC than that at 37 oC due to the temperature sensitivity of poly(N-acryloylglycinates). The experimental results indicate that pTSB seems to have a potential application in the drug release system controlled via pH or temperature in the biomedical fields.

A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

2010 ◽  
Vol 148-149 ◽  
pp. 1449-1452 ◽  
Author(s):  
Kui Lin Deng ◽  
Yu Bo Gou ◽  
Jian Zuo ◽  
Li Rong Dong ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Network ◽  
Phosphate Buffer Solution ◽  
Interpenetrating Polymer Network ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Beads ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

Sign in / Sign up

Export Citation Format

Share Document