Novel Reactive Distillation–Pervaporation Coupled Process for Ethyl Acetate Production with Water Removal from Reboiler and Acetic Acid Recycle

This paper provides a multi-aspect comparison of selected methods of ethyl acetate production and shows the possibility of further reactive distillation process integration and sophisticated intensification including process stream regeneration. The production pathways were selected with respect to their practical applicability and sufficient experimental and feasibility studies already published. A total of four case studies were designed and compared: conventional process set-up (ethyl acetate is produced in a chemical reactor) is designed as a base case study; reactive distillation with a separation unit is derived from the conventional process set-up. The mechanical and chemical approach to reactive distillation process intensification and integration were assumed: reactive distillation column with a stripper and reactive distillation column with an auxiliary chemical reaction (ethylene oxide hydration). Process models were compiled in the Aspen Plus software. Complex process flowsheets of selected case studies including separation and regeneration were designed and optimized. Three different points of view were applied to evaluate the selected process benefits and drawbacks. Process energy, economy, and safety were assessed. As a result, a reactive distillation column with an auxiliary chemical reaction has been proven to be the most suitable pathway for ethyl acetate production assuming all three evaluated aspects.

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Comparison of different reactive distillation schemes for ethyl acetate production using sustainability indicators

Chemical Engineering and Processing - Process Intensification ◽

10.1016/j.cep.2015.07.027 ◽

2015 ◽

Vol 96 ◽

pp. 1-13 ◽

Cited By ~ 25

Author(s):

Miguel A. Santaella ◽

Alvaro Orjuela ◽

Paulo C. Narváez

Keyword(s):

Ethyl Acetate ◽

Reactive Distillation ◽

Sustainability Indicators ◽

Acetate Production

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Simulation studies on homogenously catalyzed finishing reactive distillation for ethyl acetate production

Chemical Engineering Communications ◽

10.1080/00986445.2019.1574766 ◽

2019 ◽

Vol 207 (1) ◽

pp. 109-122

Author(s):

Damandeep Singh ◽

Raj Kumar Gupta ◽

Vineet Kumar

Keyword(s):

Ethyl Acetate ◽

Reactive Distillation ◽

Simulation Studies ◽

Acetate Production

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Screening lager yeast with higher ethyl-acetate production by adaptive laboratory evolution in high concentration of acetic acid

10.21203/rs.3.rs-388541/v1 ◽

2021 ◽

Author(s):

Xin Xu ◽

Chengtuo Niu ◽

Chunfeng Liu ◽

Jinjing Wang ◽

Feiyun Zheng ◽

...

Keyword(s):

Acetic Acid ◽

Ethyl Acetate ◽

Expression Level ◽

Alcoholic Beverages ◽

Moderate Degree ◽

High Concentration ◽

Acetate Production ◽

Adaptive Laboratory Evolution ◽

Lager Yeast ◽

Laboratory Evolution

Abstract Ethyl-acetate is important for the flavor and aroma of the alcoholic beverages, therefore, there have been extensive efforts toward increasing its production by engineering yeast strains. In this study, we reported a new approach to breed non-genetic modified producing yeast strain with higher ethyl-acetate production for beer brewing. First, we demonstrated the positive effect of higher acetic acid concentration on inducing the expression of ACS. Then, we applied adaptive laboratory evolution method to evolve strain with higher expression level of ACS. As a result, we obtained several strains with increased ACS expression level as well as ethyl-acetate production. In 3 L scale fermentation, the optimal strain EA60 synthesized more ethyl-acetate than M14 at the same time point. At the end of fermentation, the ethyl-acetate production in EA60 was 21.4% higher than M14, while the other flavor components except for acetic acid were changed in a moderate degree, indicating this strain had a bright prospect in industrial application. Moreover, this study also indicated that ACS1 played a more important role in increasing the acetic acid tolerance of yeast, while ACS2 contributed to the synthesis of cytosol acetyl-CoA, thereby facilitating the production of ethyl-acetate during fermentation.

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Multi-Objective Assessment of Heat Pump-Assisted Ethyl Acetate Production

Processes ◽

10.3390/pr9081380 ◽

2021 ◽

Vol 9 (8) ◽

pp. 1380

Author(s):

Branislav Šulgan ◽

Juraj Labovský ◽

Miroslav Variny ◽

Zuzana Labovská

Keyword(s):

Ethyl Acetate ◽

Heat Pump ◽

Distillation Column ◽

Reactive Distillation ◽

Process Models ◽

Final Decision ◽

Acetate Production ◽

Separation Unit ◽

Multi Objective ◽

Conventional Process

Multi-objective (energy–economic–safety) assessment of ethyl acetate production involving a heat pump is presented in this paper. The heat pump is designed to intensify ethyl acetate separation and to reduce the total operating cost. Two ethyl acetate production pathways are upgraded using a heat pump, conventional process and reactive distillation column with a separation unit. Detailed process models including the heat pump environment have been compiled and optimized in the Aspen Plus software. Both benefits and drawbacks of including the heat pump in the processes are evaluated using three different points of view: process energy, economics, and safety. As a result, using a heat pump is highly recommended in both conventional process and reactive distillation column with a separation unit. As a higher level of process integration is achieved using a heat pump, economic aspects are improved; however, safety aspects deteriorate. The final decision on the suitability of using a heat pump depends on whether it is proposed for an existing plant, or a completely new plant is designed. In a new plant, the concept of a thermally coupled process (reactive distillation column with a stripper column) has been proven to be the most promising.

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