The Interaction of Human Serum Albumin with Long-chain Fatty Acid Anions

1958 ◽  
Vol 80 (15) ◽  
pp. 3892-3898 ◽  
Author(s):  
DeWitt S. Goodman
Keyword(s):  
Fatty Acid ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Long Chain

Binding of some long-chain fatty acid anions and alcohols by bovine serum albumin

Biochemistry ◽  
1968 ◽  
Vol 7 (4) ◽  
pp. 1357-1361 ◽  
Author(s):  
Jacqueline A. Reynolds ◽  
Sarah. Herbert ◽  
Jacinto. Steinhardt
Keyword(s):  
Fatty Acid ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Long Chain

Action of carnitine on long chain fatty acid oxidation by liver

1959 ◽  
Vol 197 (2) ◽  
pp. 297-304 ◽  
Author(s):  
Irving B. Fritz
Keyword(s):  
Fatty Acid ◽  
Serum Albumin ◽  
Fatty Acid Oxidation ◽  
Chain Fatty Acid ◽  
Acid Oxidation ◽  
Direct Influence ◽  
Long Chain Fatty Acid ◽  
Fatty Acid Degradation ◽  
Long Chain ◽  
Intracellular Structure

The addition of dl-carnitine to various types of particulate liver preparations resulted in augmented oxidation of labeled palmitate and stearate. In contrast, carnitine exerted little if any effects upon the degradation of octanoate or laurate. The oxidation of palmityl-1-C14 CoA by liver particulates was not affected by the presence of carnitine, suggesting that carnitine action is at a stage prior to the formation of this intermediate. Since carnitine addition consistently induced an increase in long chain fatty acid oxidation by slices and by subcellular particulates but did not enhance fatty acid degradation by various soluble systems, it was concluded that an intracellular structure is probably required for carnitine action. A carnitine effect on the long chain fatty acid activating enzyme could not be demonstrated. It was concluded tentatively that the site of carnitine action is independent of direct influence on the known enzymes required for fatty acid oxidation. Palmitic acid oxidation by particulate preparations was inhibited by added serum albumin or calcium, and this inhibition was in large part relieved by the addition of carnitine.

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