scholarly journals Stimulation of Innate Immune Cells by Light-Activated TLR7/8 Agonists

2014 ◽  
Vol 136 (31) ◽  
pp. 10823-10825 ◽  
Author(s):  
Keun Ah Ryu ◽  
Lalisa Stutts ◽  
Janine K. Tom ◽  
Rock J. Mancini ◽  
Aaron P. Esser-Kahn
Keyword(s):  
Immune Cells ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Stimulation Of

scholarly journals Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Eva Plesch ◽  
Cheng-Chang Chen ◽  
Elisabeth Butz ◽  
Anna Scotto Rosato ◽  
Einar K Krogsaeter ◽  
...  
Keyword(s):  
Immune Cells ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Macrophage Migration ◽  
Direct Link ◽  
Direct Role ◽  
Recycling Endosomes ◽  
Cytokines And Chemokines ◽  
Selective Agonist ◽  
Stimulation Of

Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these inflammatory mediators are released from the various immune cells. Here, the endolysosomal cation channel TRPML2 is shown to play a direct role in chemokine trafficking and secretion from murine macrophages. To demonstrate acute and direct involvement of TRPML2 in these processes, the first isoform-selective TRPML2 channel agonist was generated, ML2-SA1. ML2-SA1 was not only found to directly stimulate release of the chemokine CCL2 from macrophages but also to stimulate macrophage migration, thus mimicking CCL2 function. Endogenous TRPML2 is expressed in early/recycling endosomes as demonstrated by endolysosomal patch-clamp experimentation and ML2-SA1 promotes trafficking through early/recycling endosomes, suggesting CCL2 being transported and secreted via this pathway. These data provide a direct link between TRPML2 activation, CCL2 release and stimulation of macrophage migration in the innate immune response.

scholarly journals Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae

2002 ◽  
Vol 32 (9) ◽  
pp. 2460-2470 ◽  
Author(s):  
Clarissa Prazeres da Costa ◽  
Carsten J. Kirschning ◽  
Dirk Busch ◽  
Susanne Dürr ◽  
Luise Jennen ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Immune Cells ◽  
Chlamydia Pneumoniae ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Heat Shock Protein 60 ◽  
Stimulation Of

scholarly journals The MushroomAgaricus blazeiMurill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Geir Hetland ◽  
Egil Johnson ◽  
Torstein Lyberg ◽  
Gunnar Kvalheim
Keyword(s):  
Immune Cells ◽  
Rain Forest ◽  
Scientific Evidence ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Medicinal Mushroom ◽  
Agaricus Blazei ◽  
Health Food ◽  
Inflammatory Bowel ◽  
Stimulation Of

The medicinal mushroomAgaricus blazeiMurill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind such postulations.Agaricus blazeiM is rich in the immunomodulating polysaccharides,β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effects are mediated through the mushroom's stimulation of innate immune cells, such as monocytes, NK cells, and dendritic cells, and the amelioration of a skewed Th1/Th2 balance and inflammation.

scholarly journals Redox Signaling from Mitochondria: Signal Propagation and Its Targets

Biomolecules ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 93 ◽  
Author(s):  
Petr Ježek ◽  
Blanka Holendová ◽  
Lydie Plecitá-Hlavatá
Keyword(s):  
Skeletal Muscle ◽  
Insulin Secretion ◽  
Immune Cells ◽  
Hypoxia Inducible Factor ◽  
Signal Propagation ◽  
Redox Signaling ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Stimulation Of

Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations.

Stepping out of the shadow: STIM2 promotes IL-3–induced cytokine release

2019 ◽  
Vol 12 (576) ◽  
pp. eaax0210
Author(s):  
Dalia Alansary ◽  
Barbara A. Niemeyer
Keyword(s):  
Immune Response ◽  
Immune Cells ◽  
Small Population ◽  
Innate Immune ◽  
Interleukin 4 ◽  
Innate Immune Cells ◽  
Cytokine Release ◽  
Efficient Immune Response ◽  
Stimulation Of

Basophils are a small population of innate immune cells, but their release of the cytokine interleukin-4 (IL-4) is important for mounting an efficient immune response against distinct parasites. Yoshikawa et al. (in the 9 April 2019 issue) showed that whereas STIM1 is essential for IL-4 release after stimulation of FcεRI, STIM2 mediates a delayed IL-3/IL-33–induced IL-4 release independent of STIM1.

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