scholarly journals Novel C-4 Heteroaryl 13-cis-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice

2015 ◽  
Vol 58 (4) ◽  
pp. 1900-1914 ◽  
Author(s):  
Hannah W. Mbatia ◽  
Senthilmurugan Ramalingam ◽  
Vidya P. Ramamurthy ◽  
Marlena S. Martin ◽  
Andrew K. Kwegyir-Afful ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Breast ◽  
Prostate Cancer Cells ◽  
Tumor Xenografts ◽  
Cell Proliferation And Migration ◽  
Breast And Prostate Cancer ◽  
And Migration ◽  
Human Prostate Tumor ◽  
Inhibit Cell Proliferation ◽  
Proliferation And Migration

Carvacrol/β-cyclodextrin inclusion complex inhibits cell proliferation and migration of prostate cancer cells

2019 ◽  
Vol 125 ◽  
pp. 198-209 ◽  
Author(s):  
Gabriela G.G. Trindade ◽  
Greeshma Thrivikraman ◽  
Paula P. Menezes ◽  
Cristiane M. França ◽  
Bruno S. Lima ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Inclusion Complex ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Cell Proliferation And Migration ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals FOXA1 modulates EAF2 regulation of AR transcriptional activity, cell proliferation, and migration in prostate cancer cells

The Prostate ◽  
2015 ◽  
Vol 75 (9) ◽  
pp. 976-987 ◽  
Author(s):  
Wenhuan Guo ◽  
Anne L. Keener ◽  
Yifeng Jing ◽  
Liquan Cai ◽  
Junkui Ai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Transcriptional Activity ◽  
Prostate Cancer Cells ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals CMTM5-v1 inhibits cell proliferation and migration by downregulating oncogenic EGFR signaling in prostate cancer cells

2020 ◽  
Vol 11 (13) ◽  
pp. 3762-3770 ◽  
Author(s):  
Yeqing Yuan ◽  
Zhengzuo Sheng ◽  
Zhenhua Liu ◽  
Xiaowei Zhang ◽  
Yunbei Xiao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Egfr Signaling ◽  
Prostate Cancer Cells ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Heparin Affin Regulatory Peptide/Pleiotrophin Mediates Fibroblast Growth Factor 2 Stimulatory Effects on Human Prostate Cancer Cells

2006 ◽  
Vol 281 (43) ◽  
pp. 32217-32226 ◽  
Author(s):  
Maria Hatziapostolou ◽  
Christos Polytarchou ◽  
Panagiotis Katsoris ◽  
Jose Courty ◽  
Evangelia Papadimitriou
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Human Prostate Cancer ◽  
Lncap Cells ◽  
Prostate Cancer Cells ◽  
Regulatory Peptide ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

Fibroblast growth factor 2 (FGF2) is a pleiotropic growth factor that has been implicated in prostate cancer formation and progression. In the present study we found that exogenous FGF2 significantly increased human prostate cancer LNCaP cell proliferation and migration. Heparin affin regulatory peptide (HARP) or pleiotrophin seems to be an important mediator of FGF2 stimulatory effects, since the latter had no effect on stably transfected LNCaP cells that did not express HARP. Moreover, FGF2, through FGF receptors (FGFRs), significantly induced HARP expression and secretion by LNCaP cells and increased luciferase activity of a reporter gene vector carrying the full-length promoter of HARP gene. Using a combination of Western blot analyses, as well as genetic and pharmacological inhibitors, we found that activation of FGFR by FGF2 in LNCaP cells leads to NAD(P)H oxidase-dependent hydrogen peroxide production, phosphorylation of ERK1/2 and p38, activation of AP-1, increased expression and secretion of HARP, and, finally, increased cell proliferation and migration. These results establish the role and the mode of activity of FGF2 in LNCaP cells and support an interventional role of HARP in FGF2 effects, providing new insights on the interplay among growth factor pathways within prostate cancer cells.

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