Stopped-flow study of salt effects on the hydroxide and borate ion catalyzed hydrolysis of covalent p-tolylsulfonylmethyl perchlorate in aqueous borax buffer solutions

A study is made on the kinetic salt effect on the reaction of hydrolysis of several charged esters in alkaline media. The results are interpreted on the basis of the coulombic interaction, the salting in of hydroxide ion and a third component depending on size of the substrate.

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The dielectric constant and salt effects upon the acid hydrolysis of ethyl formate

Analytica Chimica Acta ◽

10.1016/s0003-2670(00)87758-2 ◽

1954 ◽

Vol 11 ◽

pp. 401-411 ◽

Cited By ~ 3

Author(s):

Navin P. Shah ◽

Edward S. Amis

Keyword(s):

Dielectric Constant ◽

Acid Hydrolysis ◽

Ethyl Formate ◽

Salt Effects ◽

Hydrolysis Of

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Isothermal and non-isothermal kinetics of hydrolysis of 1-[2-(2- pentyloxyphenylcarbamoyloxy)-(2-methoxymethyl)-ethyl]- perhydroazepinium chloride (BK 129)

Acta Facultatis Pharmaceuticae Universitatis Comenianae ◽

10.2478/afpuc-2013-0018 ◽

2013 ◽

Vol 60 (2) ◽

pp. 43-48

Author(s):

Stankovičová M. ◽

Bezáková Ž. ◽

Beňo P. ◽

Húšťavová P.

Keyword(s):

Biological Activity ◽

Alkaline Hydrolysis ◽

Functional Group ◽

Isothermal Kinetics ◽

Basic Part ◽

Buffer Solutions ◽

Kinetics Of Hydrolysis ◽

Short Time ◽

Kinetics Of ◽

Hydrolysis Of

Abstract The substance BK 129 - 1-[2-(2-pentyloxyphenylcarbamoyloxy)-(2-methoxymethyl)-ethyl]-perhydroazepinium chloride was prepared in terms of influence of the connecting chain between the carbamate functional group and the basic part of molecule on biological activity. Such a structural feature is important with regard to its stability. In this work we determined the rate constants of alkaline hydrolysis of this compound at increased temperature under isothermal and non-isothermal conditions. The hydrolysis was also performed in buffer solutions with the purpose of evaluating its stability. Non-isothermal tests of stability enable to reduce the number of analyses. The necessary data for stability of compound are in this way achieved in a short time.

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Vinyl ether hydrolysis. XIV. 2-Methoxy-2,3-dihydropyran: concurrent reaction of vinyl ether and acetal functional groups

Canadian Journal of Chemistry ◽

10.1139/v80-353 ◽

1980 ◽

Vol 58 (21) ◽

pp. 2199-2202 ◽

Cited By ~ 5

Author(s):

R. A. Burt ◽

Y. Chiang ◽

A. J. Kresge

Keyword(s):

Vinyl Ether ◽

Isotope Effect ◽

Reaction Rate ◽

Functional Group ◽

Minor Amount ◽

Cyanoacetic Acid ◽

Buffer Solutions ◽

Hydrogen Isotope Effect ◽

A Minor ◽

Hydrolysis Of

The hydrolysis of 2-methoxy-2,3-dihydropyran shows a normal isotope effect (kH/kD > 1) under catalysis by the hydrogen ion and gives an accurately linear dependence of reaction rate upon undissociated acid concentration in cyanoacetic acid and formic acid buffer solutions. This substrate, therefore, unlike its higher homolog, 9-methoxyoxacyclonon-2-ene, provides no evidence in support of an anything but a normal mechanism for vinyl ether hydrolysis. Analysis of the hydrogen isotope effect suggests that a minor amount (8%) of this hydrolysis occurs via reaction of the acetal functional group.

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