Preparation and Characterization of Polyion Complex Micelles with a Novel Thermosensitive Poly(2-isopropyl-2-oxazoline) Shell via the Complexation of Oppositely Charged Block Ionomers†

Langmuir ◽  
2007 ◽  
Vol 23 (1) ◽  
pp. 138-146 ◽  
Author(s):  
Joon-Sik Park ◽  
Yoshitsugu Akiyama ◽  
Yuichi Yamasaki ◽  
Kazunori Kataoka
Keyword(s):  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Block Ionomers ◽  
Complex Micelles ◽  
Oppositely Charged

Characterization of Polyion Complex Micelles Designed to Address the Challenges of Oligonucleotide Delivery

2008 ◽  
Vol 25 (9) ◽  
pp. 2083-2093 ◽  
Author(s):  
Marie-Hélène Dufresne ◽  
Mahmoud Elsabahy ◽  
Jean-Christophe Leroux
Keyword(s):  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Oligonucleotide Delivery ◽  
Complex Micelles

Preparation and Characterization of Polyion Complex Micelles with Phosphobetaine Shells

Langmuir ◽  
2013 ◽  
Vol 29 (31) ◽  
pp. 9651-9661 ◽  
Author(s):  
Keita Nakai ◽  
Midori Nishiuchi ◽  
Masamichi Inoue ◽  
Kazuhiko Ishihara ◽  
Yusuke Sanada ◽  
...  
Keyword(s):  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Complex Micelles

Dendritic Macromolecular Architectures: Dendrimer-Based Polyion Complex Micelles

2021 ◽  
Vol 22 (2) ◽  
pp. 262-274
Author(s):  
Serge Mignani ◽  
Xiangyang Shi ◽  
Maria Zablocka ◽  
Jean-Pierre Majoral
Keyword(s):  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Complex Micelles

scholarly journals Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 5
Author(s):  
Noriko Nakamura ◽  
Yuki Mochida ◽  
Kazuko Toh ◽  
Shigeto Fukushima ◽  
Horacio Cabral ◽  
...  
Keyword(s):  
Physicochemical Characteristics ◽  
Charge Ratio ◽  
Structural Variations ◽  
Polyion Complex ◽  
Functional Capabilities ◽  
The Stability ◽  
Biological Performance ◽  
Complex Micelles ◽  
Oppositely Charged

Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding of the PIC formation will allow constructing assemblies with enhanced structural and functional capabilities. Here, we focused on the influence of the mixing charge ratio between block aniomers and catiomers on the physicochemical characteristics and in vivo biological performance of the resulting PIC micelles (PIC/m). Our results showed that by changing the mixing charge ratio, the structural state of the core was altered despite the sizes of PIC/m remaining almost the same. These structural variations greatly affected the stability of the PIC/m in the bloodstream after intravenous injection and determined their biodistribution.

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