Aqueous-Phase Behavior of Natural Glycolipid Biosurfactant Mannosylerythritol Lipid A:  Sponge, Cubic, and Lamellar Phases

Langmuir ◽  
2007 ◽  
Vol 23 (4) ◽  
pp. 1659-1663 ◽  
Author(s):  
Tomohiro Imura ◽  
Yusuke Hikosaka ◽  
Wannasiri Worakitkanchanakul ◽  
Hideki Sakai ◽  
Masahiko Abe ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Aqueous Phase ◽  
Lipid A ◽  
Mannosylerythritol Lipid ◽  
Glycolipid Biosurfactant ◽  
Lamellar Phases

Aqueous-phase behavior and vesicle formation of natural glycolipid biosurfactant, mannosylerythritol lipid-B

2008 ◽  
Vol 65 (1) ◽  
pp. 106-112 ◽  
Author(s):  
Wannasiri Worakitkanchanakul ◽  
Tomohiro Imura ◽  
Tokuma Fukuoka ◽  
Tomotake Morita ◽  
Hideki Sakai ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Aqueous Phase ◽  
Vesicle Formation ◽  
Mannosylerythritol Lipid ◽  
Glycolipid Biosurfactant

Enzymatic synthesis of a novel glycolipid biosurfactant, mannosylerythritol lipid-D and its aqueous phase behavior

2011 ◽  
Vol 346 (2) ◽  
pp. 266-271 ◽  
Author(s):  
Tokuma Fukuoka ◽  
Takashi Yanagihara ◽  
Tomohiro Imura ◽  
Tomotake Morita ◽  
Hideki Sakai ◽  
...  
Keyword(s):  
Phase Behavior ◽  
Aqueous Phase ◽  
Enzymatic Synthesis ◽  
Mannosylerythritol Lipid ◽  
Glycolipid Biosurfactant

scholarly journals Formation of W/O Microemulsion Based on Natural Glycolipid Biosurfactant, Mannosylerythritol Lipid-A

2008 ◽  
Vol 57 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Wannasiri Worakitkanchanakul ◽  
Tomohiro Imura ◽  
Tomotake Morita ◽  
Tokuma Fukuoka ◽  
Hideki Sakai ◽  
...  
Keyword(s):  
Lipid A ◽  
Mannosylerythritol Lipid ◽  
Glycolipid Biosurfactant

scholarly journals Synthesis, Characterization of Liposomes Modified with Biosurfactant MEL-A Loading Betulinic Acid and Its Anticancer Effect in HepG2 Cell

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3939 ◽  
Author(s):  
Qin Shu ◽  
Jianan Wu ◽  
Qihe Chen
Keyword(s):  
Betulinic Acid ◽  
Hepg2 Cells ◽  
Lipid A ◽  
Clinical Applications ◽  
Dose Effect ◽  
Anticancer Effect ◽  
Mannosylerythritol Lipid ◽  
Anti Cancer ◽  
Effect Relation

As a novel natural compound delivery system, liposomes are capable of incorporating lipophilic bioactive compounds with enhanced compound solubility, stability and bioavailability, and have been successfully translated into real-time clinical applications. To construct the soy phosphatidylcholine (SPC)–cholesterol (Chol) liposome system, the optimal formulation was investigated as 3:1 of SPC to Chol, 10% mannosylerythritol lipid-A (MEL-A) and 1% betulinic acid. Results show that liposomes with or without betulinic acid or MEL-A are able to inhibit the proliferation of HepG2 cells with a dose-effect relation remarkably. In addition, the modification of MEL-A in liposomes can significantly promote cell apoptosis and strengthen the destruction of mitochondrial membrane potential in HepG2 cells. Liposomes containing MEL-A and betulinic acid have exhibited excellent anticancer activity, which provide factual basis for the development of MEL-A in the anti-cancer applications. These results provide a design thought to develop delivery liposome systems carrying betulinic acid with enhanced functional and pharmaceutical attributes.

The aqueous phase behavior of polyion–surfactant ion complex salts mixed with nonionic surfactants

2011 ◽  
Vol 13 (8) ◽  
pp. 3126-3138 ◽  
Author(s):  
John Janiak ◽  
Lennart Piculell ◽  
Gerd Olofsson ◽  
Karin Schillén
Keyword(s):  
Phase Behavior ◽  
Aqueous Phase ◽  
Nonionic Surfactants ◽  
Complex Salts
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