The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages

To improve the performance of drug delivery systems in macrophages, targeted ligand-conjugated polymeric carriers have been realized to be vital for targeted, sustainable and controlled drug release with remarkable biocompatibility and bioavailability.

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Nanoparticulate drug delivery systems: A revolution in design and development of drugs

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v11i5-s.5023 ◽

2021 ◽

Vol 11 (5-S) ◽

pp. 188-193

Author(s):

Prashant Shukla ◽

Shweta Sharma ◽

Padma Rao

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Drug Delivery Systems ◽

Therapeutic Benefit ◽

Delivery Systems ◽

The Past ◽

Drug Molecules ◽

Recent Developments ◽

Nanoparticle Formulation ◽

Particulate Delivery

The recent developments in nanoparticle-based drug formulations have been helping to address issues around treating challenging diseases. Nanoparticles come in different sizes but usually vary between 100nm to 500nm. For the past few years there has been research going on in the area of drug delivery using particulate delivery systems. Various drug molecules have been modified for both pharmacokinetic and pharmacodynamic properties using nanoparticles as physical approach. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes. Keywords: nanoparticles, applications in delivery, Liposomes, Dendrimers

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High-content analysis for drug delivery and nanoparticle applications

Drug Discovery Today ◽

10.1016/j.drudis.2015.04.001 ◽

2015 ◽

Vol 20 (8) ◽

pp. 942-957 ◽

Cited By ~ 24

Author(s):

David J. Brayden ◽

Sally-Ann Cryan ◽

Kenneth A. Dawson ◽

Peter J. O’Brien ◽

Jeremy C. Simpson

Keyword(s):

Drug Delivery ◽

Content Analysis ◽

High Content Analysis

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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