Zidovudine and Ursodeoxycholic Acid Conjugation: Design of a New Prodrug Potentially Able To Bypass the Active Efflux Transport Systems of the Central Nervous System

2012 ◽  
Vol 9 (4) ◽  
pp. 957-968 ◽  
Author(s):  
Alessandro Dalpiaz ◽  
Guglielmo Paganetto ◽  
Barbara Pavan ◽  
Marco Fogagnolo ◽  
Alessandro Medici ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ursodeoxycholic Acid ◽  
Transport Systems ◽  
Efflux Transport ◽  
Active Efflux ◽  
The Central Nervous System

Glial Function in Homeostasis of the Neuronal Microenvironment

Physiology ◽  
1994 ◽  
Vol 9 (6) ◽  
pp. 265-267
Author(s):  
RK Orkand ◽  
SC Opava
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Small Molecules ◽  
Transport Systems ◽  
Large Area ◽  
Glial Function ◽  
The Central Nervous System ◽  
Glial Membrane ◽  
Membrane Transport Systems ◽  
Specific Membrane

Neuroglia buffer changes in the concentrations of ions and small molecules in the tortuous network of narrow extracellular clefts that constitutes the functional environment of neurons in the central nervous system. The large area of glial membrane bordering this space exhibits specific membrane transport systems for homeostasis.

scholarly journals The blood–brain barrier

2020 ◽  
pp. S32-S34
Author(s):  
S Dingezweni
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Transport Systems ◽  
Barrier Structure ◽  
Waste Products ◽  
Blood Brain ◽  
The Central Nervous System ◽  
The Brain

The blood–brain barrier (BBB) is a dynamic barrier essential for central nervous system interstitial fluid separation from circulating blood. This dynamic separation ensures maintenance of neuronal microenvironment homeostasis against that of the everchanging in solutes and toxin concentration in circulating blood. The blood–brain barrier structure is complex, it has multiple contributors, such as specialised blood microvascular endothelium, neurons, astrocytes and pericytes. Transfer of essential nutrients to the brain and waste products from the brain to circulating blood is tightly regulated and facilitated by a large surface area and specialised transport systems. It is not only the physical characteristics of the barrier that assist in maintenance of neuronal microenvironment, biochemical substances and the high trans endothelial electrical resistance also play a major role. Circumventricular organs are those parts of the central nervous system lacking the blood–brain barrier. These are essential for optimum central nervous system interaction with circulating blood directly or using neurotransmitters. Primary or secondary central nervous system pathological states, such as infective and noninfective causes, directly or indirectly induce biochemical mediators that may disrupt and alter blood–brain barrier structure and function. Understanding of the blood–brain barrier anatomy and physiology assists in developing treatment methods to overcome degenerative and pathological states negatively affecting the central nervous system.

scholarly journals Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1236
Author(s):  
Keisuke Tachibana ◽  
Yumi Iwashita ◽  
Erika Wakayama ◽  
Itsuki Nishino ◽  
Taiki Nishikaji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Endothelial Cells ◽  
Nervous System ◽  
Extracellular Fluid ◽  
Transport Systems ◽  
Brain Extracellular Fluid ◽  
The Central Nervous System ◽  
Polarized Transport ◽  
The Brain

The blood-brain barrier (BBB), which is composed of endothelial cells, pericytes, astrocytes, and neurons, separates the brain extracellular fluid from the circulating blood, and maintains the homeostasis of the central nervous system (CNS). The BBB endothelial cells have well-developed tight junctions (TJs) and express specific polarized transport systems to tightly control the paracellular movements of solutes, ions, and water. There are two types of TJs: bicellular TJs (bTJs), which is a structure at the contact of two cells, and tricellular TJs (tTJs), which is a structure at the contact of three cells. Claudin-5 and angulin-1 are important components of bTJs and tTJs in the brain, respectively. Here, we review TJ-modulating bioprobes that enable drug delivery to the brain across the BBB, focusing on claudin-5 and angulin-1.

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